A5013698449- Prostate Cancer Treatment and Research
- Estrogen and related hormone effects
- Hormonal and reproductive studies
- Ubiquitin and proteasome pathways
- Chromatin Remodeling and Cancer
- RNA modifications and cancer
- Protein Degradation and Inhibitors
University of Eastern Finland
2021-2025
Abstract Treatment of prostate cancer confronts resistance to androgen receptor (AR)-targeted therapies. AR-associated coregulators and chromatin proteins hold a great potential for novel therapy targets. Here, we employed powerful chromatin-directed proteomics approach termed ChIP-SICAP uncover the composition protein network, chromatome, around endogenous AR in castration resistant (CRPC) cells. In addition several expected coregulators, chromatome contained many nuclear not previously...
The androgen receptor (AR) is pivotal in prostate cancer (PCa) progression and represents a critical therapeutic target. AR-mediated gene regulation involves intricate interactions with nuclear proteins, many mediating undergoing post-translational modifications that present alternative avenues. Through chromatin proteomics PCa cells, we identified SUMO ligases together coregulators pioneer transcription factors within the AR's protein network. Intriguingly, this network displayed...
Steroid receptors are involved in a wide array of crosstalk mechanisms that regulate diverse biological processes, with significant implications diseases, particularly cancers. In prostate cancer, indirect between androgen receptor (AR) and glucocorticoid NR3C1 (also known as GR) is well-documented, wherein AR suppression by antiandrogen therapy leads to elevated GR levels, enabling compensate for replace signaling. However, the existence impact direct chromatin cancer remain elusive. Our...
Abstract The androgen receptor (AR) plays a central role in the development and maintenance of male phenotype. binding androgens to induces interactions between carboxyterminal ligand-binding domain highly conserved 23FQNLF27 motif aminoterminal domain. these so-called N/C AR functioning is debated. In vitro assays show that mutating (called ARNoC) attenuates transactivation reporter genes, has no effect on ligand binding, but does affect protein-protein with several coregulators. To test...
ABSTRACT Steroid receptors are involved in a wide array of crosstalk mechanisms that regulate diverse biological processes, with significant implications diseases, particularly cancers. In prostate cancer, indirect between androgen receptor (AR) and glucocorticoid (GR) is well-documented, where GR replaces antiandrogen-inactivated AR becoming the disease driver. However, existence impact direct chromatin cancer have remained elusive. Our genome-wide investigations reveal activation...