A5022222547- Prostate Cancer Treatment and Research
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- Hormonal and reproductive studies
- Estrogen and related hormone effects
- Sexual Differentiation and Disorders
- Asthma and respiratory diseases
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- Hypothalamic control of reproductive hormones
- Epigenetics and DNA Methylation
- Computational Drug Discovery Methods
- LGBTQ Health, Identity, and Policy
- Effects and risks of endocrine disrupting chemicals
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Analytical Chemistry and Chromatography
- Inflammatory mediators and NSAID effects
- Metabolism, Diabetes, and Cancer
- PARP inhibition in cancer therapy
- Receptor Mechanisms and Signaling
- CRISPR and Genetic Engineering
- Steroid Chemistry and Biochemistry
- Fibroblast Growth Factor Research
- Neonatal Respiratory Health Research
KU Leuven
2019-2025
VIB-KU Leuven Center for Cancer Biology
2023-2025
Abstract Inhibition of the androgen receptor (AR) by second-generation anti-androgens is a standard treatment for metastatic castration resistant prostate cancer (mCRPC), but it inevitably leads to development resistance. Since introduction highly efficient AR signalling inhibitors, approximately 20% mCRPC patients develop disease with independent resistance mechanisms. In this study, we generated two anti-androgen and cell models that do not rely on activity growth despite robust expression...
Transgender youth increasingly present at pediatric gender services. Some of them receive long-term puberty suppression with gonadotropin-releasing hormone analogues (GnRHa) before starting gender-affirming hormones (GAH). The impact GnRHa use started in early on bone composition and mass accrual is unexplored. It furthermore unclear whether subsequent GAH fully restore effects the timing introduction matters. To answer these questions, we developed a mouse model mimicking clinical strategy...
Bisphenols are widely used in manufacturing plastics and resins, but their environmental persistence raises concerns to human health ecosystems. Accurate measurements for bisphenols crucial effective monitoring regulation. Analytical methods detect only preselected bisphenols, while bioassays assessing estrogen receptor α activation suffer from poor sensitivity strong background signals due estrogenic contaminations. To develop a bioassay Saccharomyces cerevisiae with increased specificity...
Estrogen receptor α is commonly used in synthetic biology to control the activity of genome editing tools. The activating ligands, estrogens, however, interfere with various cellular processes, thereby limiting applicability this receptor. Altering its ligand preference chemicals choice solves hurdle but requires adaptation unspecified ligand-interacting residues. Here, we provide a solution by combining rational protein design multi-site-directed mutagenesis and directed evolution stably...
Following escape from the primary tumor, cancer cells face diverse micro-environments during metastatic cascade. To survive and establish outgrowth at a distant site, metastasizing must undergo metabolic reprogramming to adapt changing conditions. However, host in which tumors grow also experiences adaptations response various environmental factors that can mediate progression. In this review, we highlight endogenous determine metabolism (nutrient availability specific organs or microbiome),...
Abstract The androgen receptor (AR) plays a central role in the development and maintenance of male phenotype. binding androgens to induces interactions between carboxyterminal ligand-binding domain highly conserved 23FQNLF27 motif aminoterminal domain. these so-called N/C AR functioning is debated. In vitro assays show that mutating (called ARNoC) attenuates transactivation reporter genes, has no effect on ligand binding, but does affect protein-protein with several coregulators. To test...
Abstract Molecular drivers of metastasis in patients with high-risk localized prostate cancer are poorly understood. Therefore, we aim to study molecular metastatic progression cancer. A retrospective matched case-control two clinico-pathologically identical groups was undertaken. One group developed recurrence (n = 19) while the other did not 25). The primary index tumor identified by a uro-pathologist, followed DNA and RNA extraction for somatic copy-number aberration (SCNA) analysis...
Supplementary Figure from Antizyme Inhibitor 1 Regulates Matrikine Expression and Enhances the Metastatic Potential of Aggressive Primary Prostate Cancer
Supplementary Data from Antizyme Inhibitor 1 Regulates Matrikine Expression and Enhances the Metastatic Potential of Aggressive Primary Prostate Cancer
Supplementary Figure from Antizyme Inhibitor 1 Regulates Matrikine Expression and Enhances the Metastatic Potential of Aggressive Primary Prostate Cancer
Supplementary Data from Antizyme Inhibitor 1 Regulates Matrikine Expression and Enhances the Metastatic Potential of Aggressive Primary Prostate Cancer
<div>Abstract<p>Molecular drivers of metastasis in patients with high-risk localized prostate cancer are poorly understood. Therefore, we aim to study molecular metastatic progression cancer. A retrospective matched case-control two clinico-pathologically identical groups was undertaken. One group developed recurrence (<i>n</i> = 19) while the other did not 25). The primary index tumor identified by a uro-pathologist, followed DNA and RNA extraction for somatic...
<div>Abstract<p>Molecular drivers of metastasis in patients with high-risk localized prostate cancer are poorly understood. Therefore, we aim to study molecular metastatic progression cancer. A retrospective matched case-control two clinico-pathologically identical groups was undertaken. One group developed recurrence (<i>n</i> = 19) while the other did not 25). The primary index tumor identified by a uro-pathologist, followed DNA and RNA extraction for somatic...
Abstract The androgen receptor (AR) plays a crucial role in the development and maintenance of male phenotype, as shown patients with insensitivity syndrome (AIS). AR is nuclear that needs to homodimerize execute its transcription factor. Dimerization can occur through three different modes: via DNA-binding domain (DBD), ligand-binding an interaction between LBD aminoterminal domain. DBD very well known occurs D-box located second zinc finger. dimerization generally accepted for all steroid...
Abstract The androgen receptor (AR) is a nuclear with main role in the development and maintenance of male phenotype. To execute its as transcription factor, AR forms homodimers. Three dimerization modes have been described for AR: one via DNA binding domain, second ligand domain (LBD) third interactions between LBD aminoterminus (N/C). Based exclusively on vitro data, all three seem to contribute full activity, albeit different extent. vivo modes, however, remains unknown. study...