A5015828777- Gut microbiota and health
- Extracellular vesicles in disease
- Barrier Structure and Function Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Infant Nutrition and Health
- Clostridium difficile and Clostridium perfringens research
- Bacterial Infections and Vaccines
- Oral microbiology and periodontitis research
- Neonatal and Maternal Infections
- Pediatric Urology and Nephrology Studies
- Neonatal Respiratory Health Research
- Dental Research and COVID-19
- Dental materials and restorations
- Probiotics and Fermented Foods
- Adolescent and Pediatric Healthcare
- Cardiovascular Disease and Adiposity
- Exercise and Physiological Responses
- Pediatric Pain Management Techniques
- Enterobacteriaceae and Cronobacter Research
University of Oulu
2018-2025
Reports regarding the presence of bacteria in fetal environment remain limited and controversial. Recently, extracellular vesicles secreted by human gut microbiota have emerged as a novel mechanism for host-microbiota interaction. We aimed to investigate bacterial during healthy pregnancies determine whether derived from can cross biological barriers reach fetus.Bacterial were detectable amniotic fluid pregnant women, exhibiting similarities found maternal microbiota. In mice, intra-amniotic...
Gut microbiome–derived nanoparticles, known as bacterial extracellular vesicles (bEVs), have garnered interest promising tools for studying the link between gut microbiome and human health. The diverse composition of bEVs, including their proteins, mRNAs, metabolites, lipids, makes them useful investigating diseases such cancer. However, conventional approaches alone may not be accurate in deciphering host–gut communication. In clinical research, there is a gap knowledge on role bEVs solid...
Abstract We critically evaluated the fetal microbiome concept in 44 neonates with placenta, amniotic fluid, and first-pass meconium samples. Placental histology showed no signs of inflammation. Meconium samples were more often bacterial culture positive after vaginal delivery. In next-generation sequencing 16S gene, before removal extracellular PCR contaminant DNA, median number reads was low placenta (48) fluid (46) high (14,556 C-section, 24,860 vaginal). electron microscopy, vesicles....
ABSTRACT Extracellular vesicles (EVs), nanoparticles secreted by both gram-negative and gram-positive bacteria, carry various biomolecules cross biological barriers. Gut microbiota-derived EVs are currently being investigated as a communication mechanism between the microbiota host. Few clinical studies, however, have gut EVs. Here, we show that machine learning models were able to accurately distinguish respective EV samples according their taxonomic composition within each data set (area...
Abstract Background Bacterial extracellular vesicles (EVs) are more likely to cross biological barriers than whole-cell bacteria. We previously observed EV-sized particles by electron microscopy in the first-pass meconium of newborn infants. hypothesized that EVs may be bacterial origin and represent a novel entity human microbiome during fetal perinatal periods. Methods extracted from samples 17 infants performed 16S rRNA gene sequencing vesicles. compared EV content based on delivery mode,...
The aim of this study was to evaluate the surface roughness fixed prosthodontic materials after polishing or roughening with a stainless steel curette ultrasonic scaler and examine effect these on Streptococcus mutans adhesion biofilm accumulation. Thirty specimens (10 × 10 3 mm3) zirconia (Zr), pressed lithium disilicate (LDS-Press), milled glazed (LDS-Glaze), titanium grade V (Ti) cobalt-chromium (CoCr) were divided into three groups (n = 10) according treatment: polished (C), roughened...
Sweat contains biomarkers for real-time non-invasive health monitoring, but only a few relevant analytes are currently used in clinical practice. In the present study, we investigated whether sweat-derived extracellular vesicles (EVs) can be as source of potential protein human and bacterial origin.
Brown adipose tissue (BAT) expresses uncoupling protein-1 (UCP1), which enables energy to be exerted towards needed thermogenesis. Beige adipocytes are precursor cells interspersed among white (WAT) that possess similar UCP1 activity and capacity for The raccoon dog (Nyctereutes procyonoides) is a canid species utilizes seasonal obesity survive periods of food shortage in climate zones with cold winters. potential recruit part the abundant WAT storages as beige UCP1-dependent thermogenesis...