Abstract Background Intracavernous injection of mesenchymal stem cells (MSCs) is a promising method for diabetic mellitus-induced erectile dysfunction (DMED), but short survival time MSCs in cavernous fatal defect therapy. This study investigated therapeutic efficiency and potential mechanism probucol combined with MSCs. Methods In vivo study, total forty-eight 10-week-old male Sprague-Dawley (SD) rats were used. Twelve received intraperitoneal PBS as the sham group; rest 60 mg/kg...

Abstract Background Bladder cancer is a common malignancy of the urinary system, and survival rate recurrence patients with muscular aggressive (MIBC) bladder are not ideal. Hypoxia pathological process in which cells acquire special characteristics to adapt anoxic environment, can directly affect proliferation, invasion immune response cells. Understanding exact effects hypoxia immune-related genes BLCA helpful for early assessment prognosis BLCA. However, prognostic model based on has been...

Background: Parkinson's disease (PD) is an irreversible, chronic degenerative of the central nervous system, potentially associated with cerebral white matter (WM) lesions. Investigating microstructural alterations within WM in early stages PD can help to identify and enable intervention reduce serious threats health.

The associations between segmental body composition and metabolic diseases remain equivocal. This study aimed to investigate this association using the example of U.S. adults. cross-sectional included 12,148 participants from National Health Nutrition Examination Survey (NHANES) (2011-2018). Multivariable logistic regression models were used estimate quartiles hypertension, hypercholesterolemia, diabetes. Among participants, 3,569, 5,683, 1,212 had diabetes, respectively. After adjusting for...

Autophagy and apoptosis have been regarded as important processes in the development of diabetic erectile dysfunction (DMED). Probucol is considered to anti-apoptotic effects, but its relationship with autophagy has not reported. The aim this study was investigate effects mechanisms probucol on function. Thirty Sprague–Dawley (SD) male rats (12 weeks old) were fasted for 12 h. Twenty SD injected a single intraperitoneal injection 60 mg kg−1 streptozotocin (STZ). Ten given vehicle only used...

Heparin (HP) is a polysaccharide that widely used in the clinic as an anticoagulant. A major side effect associated with HP heparin-induced thrombocytopenia (HIT), which initiated by immune response to complex formed and platelet factor 4 (PF4). Low molecular weight heparins (LMWHs) are depolymerized version of HP, have reduced risks inducing HIT. However, it still necessary evaluate immunogenicity LMWHs ensure their drug safety. Since HIT involves very complicated processes, evaluation LMWH...

Obesity and vitamin D deficiency are both considered risk factors for mortality, but the potential additive effects of status obesity on mortality has not been well-studied. We aimed to examine possible all-cause cause-specific mortality. The data from NHANES III (1988–1994) 2001–2014 surveys were used, multivariate Cox regression models performed assess overweight/obesity/abdominal all-cause, cardiovascular cancer by stratifying Hazard Ratios (HRs) across different categories body mass...

OBJECTIVE In other specialties, malnutrition has been shown to be closely linked postoperative complications. However, there is no research on the relationship between nutritional parameters and complications of transsphenoidal pituitary surgery. This study was designed identify preoperative markers in nonfunctioning adenomas. METHODS observational included 429 patients whose first surgery performed Shandong Provincial Hospital January 2015 July 2020. Preoperative prealbumin, retinol-binding...

To improve conventional chemotherapeutic efficacy, it is significant to identify novel molecular markers for chemosensitivity as well possible molecules accelerating cell-killing mechanisms. In this study, we attempted elucidate how MK2206, an allosteric Akt inhibitor, enhances the cisplatin (CDDP)-induced cytotoxicity and apoptosis in testicular cancer.We checked three cancer cell lines expression of phospho(p)-Akt its downstream targets by Western blot. The potential antitumor effects were...

Hypertension increases the global burden of disease and mortality. Iron metabolism is considered to be an important factor in hypertension. However, as indicator iron metabolism, little known about associations soluble transferrin receptor (sTfR) with We studied relationship between sTfR

Copper has high electrical and thermal conductivity, which is frequently employed in structural functional materials. In this research, powder metallurgy was used to incorporate boron nanosheets into metal matrix composites create dispersion-enhanced copper composites. The neutron-absorption characteristics of composite materials were investigated, as well the link between cross-section neutron energy. results told us that morphology second phase on particle surface closely related size Cu-B...

Abstract Background Bladder cancer is a common malignancy of the urinary system, and survival rate recurrence patients with muscular aggressive (MIBC) bladder are not ideal. Hypoxia pathological process in which cells acquire special characteristics to adapt anoxic environment, can directly affect proliferation, invasion immune response cells. Understanding exact effects hypoxia immune-related genes BLCA helpful for early assessment prognosis BLCA. However, prognostic model based on has been...

To mitigate the potential for conflicts among aircraft navigating on surface and enhance operational efficiency safety at airports, this study explores various types of taxiing between presents an A* algorithm model. This model considers both distance direction, aiming to achieve conflict-free taxiway scheduling. By minimizing overall duration flights, approach enhances efficiency. Simulation analyses are conducted with illustrative examples, indicating that proposed optimization method...

The preparation of boron nanosheets has very strict requirements the environment and substrate. In this work, were tried to prepare by grinding method, using β-B alloy with stable chemical properties large crystal plane spacing. Its morphology bonds analyzed scanning microscope (SEM), transmission (TEM), X-ray photoelectron spectroscopy (XPS). results show that two-dimensional can be prepared from powder method. There are few B-O in particles, B-B principally dominant. addition a bonds,...

Safe and non-invasive on-demand relief is a crucial effective treatment for postoperative pain because it considers variable timing intensity of anesthetics. Ultrasound modulation promising technique this allows convenient timed controlled drug release. Here, we created an ultrasound-triggered lidocaine (Lido) release platform using amino acid hydrogel functioning as three-dimensional (3D) scaffold material (Lido-PPIX@ER hydrogel). It control the timing, duration to relieve pain. The...

Abstract Background Bladder cancer is a common malignancy of the urinary system, and survival rate recurrence patients with muscular aggressive (MIBC) bladder are not ideal. Hypoxia pathological process in which cells acquire special characteristics to adapt anoxic environment, can directly affect proliferation, invasion immune response cells. Understanding exact effects hypoxia immune-related genes BLCA helpful for early assessment prognosis BLCA. However, prognostic model based on has been...

This study was to explore the effect and mechanism of Probucol on STZ-induced erectile dysfunction in diabetic rats. Thirty SD male rats aged 12 weeks were given intraperitoneal injection STZ after fasting for hr. Diabetic haphazardly partitioned under two assemblies administered 0 or 500 mg/kg probucol by oral gavage weeks. Control group intraperitoneally injected with physiological saline, saline daily. Intracorporeal pressure used evaluate function. Levels proteins detected using...