A5100661080- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- Angiogenesis and VEGF in Cancer
- Genetics and Neurodevelopmental Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Protein Degradation and Inhibitors
- Renal cell carcinoma treatment
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Genomics, phytochemicals, and oxidative stress
- Tuberous Sclerosis Complex Research
- Vascular Tumors and Angiosarcomas
- Galectins and Cancer Biology
- Phagocytosis and Immune Regulation
Kosin University
2023-2025
Catholic University of Korea
2013-2023
Seoul National University
2014
Seonam University
2001-2006
Chungnam National University
2002
// Hyung Seok Kim 1,2,* , Kyo Sun Lee 3,* Hyun Jin Bae 1,2 Jung Woo Eun Qingyu Shen Se Park Chan Shin Hee Doo Yang Mijung Won Sang Yong-Koo Kang 3 and Suk Nam 1,2,4 1 Lab of Oncogenomics, Department Pathology, College Medicine, The Catholic University Korea, Seoul, Republic Korea 2 Functional RNomics Research Center, Orthopedic Surgery, Gyeonggi-do, 4 Cancer Evolution * These authors contributed equally to this work Correspondence to: Nam, email: Keywords : Hepatocellular carcinoma,...
An accurate tool enabling early diagnosis of hepatocellular carcinoma (HCC) is clinically important, given that detection HCC markedly improves survival. We aimed to investigate the molecular markers underlying progression can be detected in precancerous lesions. designed a gene selection strategy identify potential driver genes by integrative analysis transcriptome and clinicopathological data human multistage tissues, including lesions, low‐ high‐grade dysplastic nodules. The process was...
Histone deacetylase 6 (HDAC6) uniquely serves as a tumor suppressor in hepatocellular carcinogenesis, but the underlying mechanisms leading to suppression are not fully understood. To identify comprehensive microRNAs (miRNAs) regulated by HDAC6 differential miRNA expression analysis of ‐transfected Hep3B cells was performed. Using integrative analyses publicly available transcriptome data and target prediction, we selected five candidate miRNAs and, through vitro functional validation,...
Hepatocellular carcinoma (HCC) is characterized by high recurrence and mortality, necessitating the identification of reliable biomarkers. In this study, we aimed to identify predictive gene signatures for HCC evaluate efficiency GULP PTB domain-containing engulfment adaptor 1 (GULP1) as a diagnostic marker therapeutic target HCC. We analyzed genomic datasets from The Cancer Genome Atlas Gene Expression Omnibus databases via least absolute shrinkage selection operator Cox regression 10-fold...
// Hee Doo Yang 1, 3, * , Pum-Joon Kim 2, Jung Woo Eun 3 Qingyu Shen Hyung Seok Chan Shin Young Min Ahn 4 Won Sang Park 1 Lee Suk Nam 5 Laboratory of Oncogenomics, Department Pathology, College Medicine, The Catholic University Korea, Seoul 06591, Republic Korea 2 Cardiology, Functional RNomics Research Center, Kidney System, Oriental Kyung University, 02447, Cancer Evolution These authors contributed equally to this work Correspondence to: Nam, e-mail: swnam@catholic.ac.kr Keywords:...
Aberrant adenosine-to-inosine (A-to-I) RNA editing, catalyzed by adenosine deaminase acting on double-stranded (ADAR), has been implicated in various cancers, but the mechanisms which microRNA (miRNA) editing contributes to cancer development are largely unknown. Our multistage hepatocellular carcinogenesis transcriptome data analyses, together with publicly available data, indicated that ADAR1 was most profoundly dysregulated gene among RNA-editing enzyme family members liver cancer....
Aberrant regulation of histone deacetylase 2 (HDAC2) contributes to malignant progression in various cancers, but the underlying mechanism leading activation oncogenic HDAC2 remains unknown. In this study, we show that expression is upregulated a large cohort patients with human hepatocellular carcinoma, and high was significantly associated poor prognosis carcinoma. We found mTORC1/NF-κBp50 signaling necessary for growth factor-induced sustained not normal hepatic cells. Growth mTORC1...
Abstract Background and Objectives PTEN is a candidate tumor suppressor gene in variety of malignant tumors, including renal cell carcinoma (RCC). regulates cycle progression survival vivo. However, the role alterations their association with growth behavior patients RCC has not been well established. The aim our study was to evaluate expression its correlation clinicopathologic features, proliferation, apoptosis. Methods Sixty‐seven specimens were examined immunohistochemically anti‐PTEN...
Abstract MicroRNAs (miRNAs) engage in complex interactions with the machinery that controls transcriptome and concurrently target multiple mRNAs. Here, we demonstrate microRNA‐495‐3p (miR‐495‐3p) functions as a potent tumor suppressor by governing ten oncogenic epigenetic modifiers (EMs) gastric carcinogenesis. From large cohort datasets of cancer (GC) patients available from The Cancer Genome Atlas (TCGA) National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO),...
Cancer-associated fibroblasts (CAFs) contribute to tumor progression, and microRNAs (miRs) play an important role in regulating the tumor-promoting properties of CAFs. The objectives this study were clarify specific miR expression profile CAFs hepatocellular carcinoma (HCC) identify its target gene signatures. Small-RNA-sequencing data generated from nine pairs para-cancer isolated human HCC para-tumor tissues, respectively. Bioinformatic analyses performed HCC-CAF-specific signatures...
Abstract We investigated the therapeutic potential and mechanisms of HR-19011, a novel eIF2α phosphorylation inducer, with focus on its effects integrated stress response (ISR) pathway cell cycle regulation in K562 cells. Our findings revealed that HR-19011 exerts anticancer primarily through activation heme-regulated inhibitor (HRI), leading to eukaryotic translation initiation factor 2 (eIF2)α, induction ISR signaling, subsequent G1/S arrest. RNA sequencing analysis further highlighted...
Abstract Background and Objectives: Vascular endothelial growth factor (VEGF) seems to play an important role in tumor angiogenesis. The tumor‐suppressor gene p53 has been thought regulate VEGF expression. We investigated the effect of expression on renal cell carcinoma (RCC) correlation between angiogenesis protein Methods: Sixty‐two RCCs were examined by immunohistochemical studies with anti‐VEGF, anti‐p53, anti‐CD34 antibodies. Results: Forty tumors (80.6%) classified as positive, 28...
X-linked hyper-IgM syndrome (XHIM) is a rare primary immunodeficiency disorder, caused by mutations of the gene encoding CD40 ligand (CD40L; CD154). We report clinical manifestations and mutational analysis CD40L observed in male patient from XHIM family. Having hypogammaglobulinemia elevated IgM, 3-yr-old boy exhibited characteristic features XHIM. The suffered frequent respiratory infections, chronic enteritis Cryptosporidium parvum. In addition, lymph node biopsy culture this sample...
Loss of PTEN expression has been associated with advanced stages tumor. Tumor angiogenesis is involved in tumor progression. In breast cancer, a high frequency mutations the locus reported. However, prognostic importance and its correlation cancer have not well established. Formalin-fixed, paraffin-embedded tissues from 99 women primary diagnosis invasive ductal carcinoma were evaluated for by immunohistochemical methods. The microvessel density (MVD) was also studied labeling endothelial...
Abstract Background and Objectives Loss of PTEN expression has been associated with tumor progression adverse patient outcome. The purpose this study was to evaluate in the successive steps cervical neoplasia determine its correlation angiogenesis clinicopathologic features squamous cell carcinoma uterine cervix. Methods Immunohistochemical staining anti‐PTEN antibody performed a total 160 patients 12 normal epithelium, 63 intraepithelial (33 CIN I, 30 III), 85 carcinomas. Microvessels were...
Recurrence and metastasis are major challenges in the management of hepatocellular carcinoma (HCC) patients after resection. To identify a metastasis-associated gene signature, we performed comparative expression analysis with recurrent HCC tissues from who underwent partial or total hepatectomy non-metastatic primary tissues. From this, were able to genes associated recurrence. TCIRG1 (T-Cell Immune Regulator 1) was one aberrantly overexpressed had undergone hepatectomy. The significant...
Epithelial-to-mesenchymal transition (EMT) plays a critical role in the development and progression of lung cancer by promoting its invasiveness metastasis. Using integrative analyses public database, we found that expression levels tight junction proteins, zonula occluden (ZO)-1 ZO-2, were lower tissues, including both adenocarcinoma squamous cell carcinoma than normal tissues analyzed using The Cancer Genome Atlas (TCGA). Although ectopic or knockdown ZO-1 ZO-2 did not affect growth cells,...