Endothelial progenitor cells (EPCs) are mobilized from bone marrow to peripheral blood and contribute angiogenesis in tissues. In the process, EPCs exposed shear stress generated by flow tissue fluid flow. Our previous study showed that promotes differentiation of into mature endothelial cells. this study, we investigated whether differentiate arterial or venous response stress. When cultured derived human were controlled levels a flow-loading device, mRNA cell markers ephrinB2, Notch1/3,...

Embryonic stem (ES) cells are exposed to fluid-mechanical forces, such as cyclic strain and shear stress, during the process of embryonic development but much remains be elucidated concerning role forces in ES cell differentiation. Here, we show that induces vascular smooth muscle (VSMC) differentiation murine cells. Flk-1-positive (Flk-1 + ) seeded on flexible silicone membranes were subjected controlled levels examined for changes proliferation expression various lineage markers. When...

Endothelial cells (ECs) release ATP in response to shear stress, a mechanical force generated by blood flow, and the released modulates EC functions through activation of purinoceptors. The molecular mechanism stress-induced release, however, has not been fully elucidated. In this study, we have demonstrated that cell surface synthase is involved release. Immunofluorescence staining human pulmonary arterial ECs (HPAECs) showed distributed lipid rafts co-localized with caveolin-1, marker...

We developed a quantitative method to measure movement representations of phantom upper limb using bimanual circle-line coordination task (BCT). investigated whether short-term neurorehabilitation with virtual reality (VR) system would restore voluntary and alleviate pain (PLP).Eight PLP patients were enrolled. In the BCT, they repeatedly drew vertical lines intact hand intended draw circles limb. Drawing mentally led emergence an oval transfiguration ('bimanual-coupling' effect)....

Maintaining an appropriate distance from others is important for establishing effective communication and good interpersonal relations. Autism spectrum disorder (ASD) a developmental associated with social difficulties, it thus worth examining whether individuals ASD maintain typical or atypical degrees of distance. Any atypicality distancing may impact daily interactions. We measured the preferred distances when typically developing (TD) approached other people (a male experimenter) objects...

Previous models or hypotheses of autism spectral disorder (ASD) failed to take into full consideration the chronological and causal developmental trajectory, leading emergence diverse phenotypes through a complex interaction between individual etiologies environmental factors. Those include persistent deficits in social communication (criteria A DSM-5), restricted, repetitive patterns behavior, interests, activities B DSM-5). In this article, we proposed domain-general model that can explain...

Patients who suffer from phantom limb pain can perceive tactile stimuli applied to the cheek on their affected side as if it were coming limb, a phenomenon called "referred sensation."To investigate analgesic effect produced by feedback provided during neurorehabilitation using visual feedback.Nine participants with upper performed virtual reality exercises in which they repeatedly touched target object representation of limb. We when (Cheek Condition). also included 2 control conditions...

Previous studies have tried to relieve deafferentation pain (DP) by using virtual reality rehabilitation systems. However, the effectiveness of multimodal sensory feedback was not validated. The objective this study is DP neurorehabilitation a system with and validate efficacy tactile on immediate reduction. We developed applied it seven patients caused brachial plexus avulsion or arm amputation. executed reaching task phantom limb manipulated their real intact limb. conducted under two...

Recent studies have suggested that autistic perception can be attributed to atypical Bayesian inference; however, it remains unclear whether the inference originates in perceptual or post-perceptual stage both. This study examined serial dependence orientation at and response stages neurotypical adult groups. Participants comprised 17 23 adults. They reproduced of a Gabor stimulus every odd trial its mirror even trial. In similar-stimulus session, right-tilted was always presented; hence,...

Individuals with autism spectrum disorders (ASD) often exhibit difficulties in sensory processing, including visual hypersensitivity such as photophobia. This study investigates the neural mechanisms underlying photophobia participants ASD by analyzing pupillary responses. To achieve this, we examined amplitude and velocity gradient (latency) of these Pupillary responses were recorded using an eye-tracking system (n = 17) typically developing (TD) 23). Stimuli alternated between bright...

Amputees usually perceive vivid awareness of their lost body parts after the amputation (phantom limbs). Phantom limb pain (PLP) is intense that felt in phantom limb. The mechanism PLP still unclear, but major hypothesis it derived from dysfunction brain. There are a few neurorehabilitation techniques using mirror or virtual reality (VR) present visual image to patients, and this produce movement perception Here, we developed multimodal (visual, auditory, tactile) VR system obtain voluntary...

The size and regulation of personal space are reportedly atypical in autistic individuals. As regulates social interaction, its developmental change is essential for understanding the nature difficulties that individuals face. Adolescence an important period which relationships become complex. We conducted a three-year longitudinal study interpersonal distances typically developing (TD) aged 12–18 years at Time 1 15–21 2. Their preferred were measured when experimenter approached...

Abstract Tactile atypicality in individuals with autism spectrum disorder (ASD) has harmful effects on their everyday lives including social interactions. However, whether tactile ASD reflects perceptual and/or autonomic processes is unknown. Here, we show that adults have hypersensitivity to stimuli the but not domain. In particular, showed a greater skin conductance response (SCR) compared typically developing (TD) adults, despite an absence of differences subjective responses....

The objective of this study is to demonstrate the reliability relief from phantom limb pain in neurore-habilitation using a multimodal virtual reality system. We have developed rehabilitation system with sensory feedback and applied it six patients brachial plexus avulsion or arm amputation. In an experiment, executed reaching task displayed three-dimensional computer graphic environment manipulated by their real intact limb. intensity was evaluated through short-form McGill questionnaire....

Individuals with autism spectrum disorder (ASD) show impaired social interaction and communication, which may be related to their difficulties in speech production. To investigate the mechanisms of atypical production this population, we examined feedback control by delaying auditory own speech, degraded fluency. We also feedforward adding loud pink noise feedback, led increased vocal effort producing speech. The results Japanese speakers that, compared neurotypical (NT) individuals,...

Virtual reality (VR) systems have been integrated into rehabilitation techniques for phantom limb pain (PLP). In this case report, we used electroencephalography (EEG) to analyze corticocortical coherence between the bilateral sensorimotor cortices during vibrotactile stimulation in conjunction with VR two PLP patients. As a result, observed alleviation and increased alpha wave when was delivered cheek shoulder (referred sensation areas) of affected side. Vibrotactile may enhance awareness...

Previous psychophysical studies reported a positive aftereffect in tactile temporal order judgments, which can be explained by the Bayesian estimation model ('Bayesian calibration'). We investigated relationship between calibration and autistic traits participants with typical development (TD) autism spectrum disorder (ASD). was weakened TD high traits, consistent 'hypo-priors' hypothesis for perceptions. The results from ASD group were generally observed as continuation of those groups....

Coronavirus disease 2019 (COVID-19) has substantially affected the health and lives of medical professionals. However, experiences nurses engaged in primary care remain unclear. We explored how working were psychologically socially by COVID-19 disaster they overcame difficulties experienced.

Stigma of autism spectrum disorders (ASD) is a crucial factor leading to lower quality life for individuals with ASD. This research evaluated an intervention effect the stigma through experience simulated autistic visual perception and video-based social contact. The was conducted as experiential workshop ASD simulator. Participants ( N = 217; 156 women, 61 men; mean age 41.3) voluntarily attended workshop. In workshop, they received short lecture on perception, using simulator, narrative...