A5016955321- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Graphene and Nanomaterials Applications
- Extracellular vesicles in disease
- Diamond and Carbon-based Materials Research
- Respiratory viral infections research
- COVID-19 diagnosis using AI
- Immune responses and vaccinations
- Spectroscopy and Chemometric Analyses
- Vitamin D Research Studies
- Cancer Cells and Metastasis
- Uterine Myomas and Treatments
- Fullerene Chemistry and Applications
- Single-cell and spatial transcriptomics
- Thermography and Photoacoustic Techniques
Wellcome Sanger Institute
2021-2025
European Bioinformatics Institute
2023
University of Cambridge
2018
Cancer Research UK
2018
Abstract The endometrium, the mucosal lining of uterus, undergoes dynamic changes throughout menstrual cycle in response to ovarian hormones. We have generated dense single-cell and spatial reference maps human uterus three-dimensional endometrial organoid cultures. dissect signaling pathways that determine cell fate epithelial lineages lumenal glandular microenvironments. Our benchmark organoids reveals states regulating differentiation secretory ciliated both vivo vitro. In vitro...
Live cell Raman micro-spectroscopy is emerging as a promising bioanalytical technique for label-free discrimination of range different types (e.g. cancer cells and fibroblasts) behaviors apoptosis). The aim this study was to determine whether confocal shows sufficient sensitivity specificity identification primary human bronchial epithelial (HBECs) be used live biological studies in vitro. We first compared preparation substrates media, considering their influence on lung proliferation...
Abstract The endometrium, the mucosal lining of uterus, undergoes dynamic changes throughout menstrual cycle in response to ovarian hormones. We have generated single-cell and spatial reference maps human uterus 3D endometrial organoid cultures. dissect signalling pathways that determine cell fate epithelial lineages lumenal glandular microenvironments. Our benchmark organoids highlights common regulating differentiation secretory ciliated lineage vivo vitro . show downregulation WNT or...
The most common cause of death due to COVID-19 remains respiratory failure. Yet, our understanding the precise cellular and molecular changes underlying lung alveolar damage is limited. Here, we integrate single cell transcriptomic data donor tissue with spatial stratifying histopathological stages diffuse damage. We identify in composition across progressive damage, including waves molecularly distinct macrophages depletion epithelial endothelial populations. Predicted markers pathological...
We show here that oxidised nanodiamonds improved biocompatibility compared to graphitic when applied in living cells.
Abstract The most common cause of death due to COVID-19 remains respiratory failure. Yet, our understanding the precise cellular and molecular changes underlying lung alveolar damage is limited. Here, we integrate single cell transcriptomic data donor lungs with spatial stratifying histopathological stages diffuse (DAD). We identify in composition across progressive DAD, including waves molecularly distinct macrophages depleted epithelial endothelial populations throughout different types...