A5047289202- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- Vibrio bacteria research studies
- Genomics and Phylogenetic Studies
- Aquaculture disease management and microbiota
- Berberine and alkaloids research
- Microbial infections and disease research
- Antimicrobial Peptides and Activities
- Synthesis and bioactivity of alkaloids
- Marine Sponges and Natural Products
- Biochemical and Structural Characterization
- Phytochemical compounds biological activities
- Microbial Natural Products and Biosynthesis
- Bacterial biofilms and quorum sensing
- Plant Virus Research Studies
- Insect symbiosis and bacterial influences
VIB-VUB Center for Structural Biology
2021-2024
Vlaams Instituut voor Biotechnologie
2021-2024
Vrije Universiteit Brussel
2021-2024
Nagoya University
2024
View Large Image Figure ViewerDownload Hi-res image Download (PPT)KEY FACTS:Isolation of extensively resistant and pan-drug-resistant strains ranked as 'high priority' by the WHO (global priority list antibiotic-resistant bacteria to guide research, discovery development new antibiotics, 2017) CDC (antibiotic resistance threats in USA, 2019).Belongs 'ESKAPE' group most problematic nosocomial pathogens.Resistant desiccation, disinfectant, oxidative stress, complement-mediated killing.First...
Abstract We identify a new mechanism mediating capsule production and virulence in the WHO CDC priority ESKAPE pathogen Acinetobacter baumannii. Non-capsulated avirulent bacteria can revert into capsulated virulent state upon scarless excision of an ISAba13 insertion sequence under stress conditions. Reversion events fully restore vivo virulence. This increases our knowledge about A. baumannii genome dynamics, regulation production, resistance.
Abstract Acinetobacter baumannii is an important threat worldwide due to its ability acquire antibiotic resistance and survive harsh conditions. The polysaccharide capsule represents a major virulence asset. How the capsular polysaccharides barrier impacts bacterial adhesion remains be investigated in A. baumannii. We characterized mutants of commonly used AB5075 strain. assessed how these different adhere biotic (bacterial eukaryotic cells) abiotic surfaces (polystyrene). confirmed our...
The spread of antibiotic resistant bacteria is an important threat for human health. Acinetobacter baumannii impose such a major issue, as multidrug- to pandrug-resistant strains have been isolated, rendering some infections untreatable. In this context, carbapenem-resistant A. were ranked top priority by both WHO and CDC. addition, survive in harsh environments, being capable resisting disinfectants persist prolonged periods desiccation. Due the high degree variability found isolates,...
Membrane interaction constitutes to be an essential parameter in the mode of action entities such as proteins, well cell-penetrating and antimicrobial peptides, resulting noninvasive or lytic activities depending on membrane compositions interactions. Recently, a nanobody able interact with top priority, multidrug-resistant bacterial pathogen Acinetobacter baumannii was discovered, although binding took place fixed cells only. To potentially overcome this limitation, linear peptides...
Phage therapy is gaining increasing interest in the fight against critically resistant nosocomial pathogens. However, narrow host range of bacteriophages hampers development broadly effective phage therapeutics and demands precision approaches. Here we combine large-scale phylogeographical analysis with high-throughput typing to guide cocktails targeting carbapenem-resistant Acinetobacter baumannii, a top-priority pathogen. Our reveals that few strain types dominate infections each world...
Abstract In this study, we evaluated the antimicrobial activity of bacteria isolated from marine sponges Hymeniacidon perlevis and Halichondria panicea against seven Acinetobacter baumannii strains, majority which were clinically relevant carbapenem-resistant A. strains. We observed inhibitory 18 (out 114) sponge-isolated bacterial strains all using medium-throughput solid agar overlay assays. These belonged to genera Lactococcus, Pseudomonas, Vagococcus. addition, was validated through a...
Abstract Phage therapy is gaining increasing interest in the fight against critically resistant nosocomial pathogens. However, narrow host range of bacteriophages hampers development broadly effective phage therapeutics and demands precision approaches. Here we combine large-scale phylogeographical analysis with high-throughput typing to guide cocktails targeting carbapenem-resistant Acinetobacter baumannii, a top-priority pathogen. Our reveals that few strain types dominate infections each...
Abstract Aims In this study, we evaluate the antimicrobial activity of bacteria isolated from marine sponges Hymeniacidon perlevis and Halichondria panicea against clinically relevant carbapenem-resistant Acinetobacter baumannii (CRAb) isolates. Methods results We observe inhibitory 18 (out 114) sponge-isolated bacterial strains using medium throughput solid agar overlay assays. These belong to genera Lactococcus, Pseudomonas Vagococcus. addition, is validated through a liquid co-cultivation...
Synopsis Objectives The spread of antibiotic resistant bacteria is an important threat for human healthcare. Acinetobacter baumannii impose one the major issues, as multidrug- to pandrug-resistant strains have been found, rendering some infections untreatable. In addition, A. a champion in surviving harsh environments, being capable resisting disinfectants and persist prolonged periods desiccation. Due high degree variability found isolates, search new antibacterials challenging. Here, we...