A5072057149- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Autism Spectrum Disorder Research
- Advanced Neuroimaging Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Genetics and Neurodevelopmental Disorders
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Neural and Behavioral Psychology Studies
- Obsessive-Compulsive Spectrum Disorders
- Photoreceptor and optogenetics research
- Lung Cancer Treatments and Mutations
- Prostate Cancer Treatment and Research
- Memory and Neural Mechanisms
- Decision-Making and Behavioral Economics
- Cancer Genomics and Diagnostics
- Visual perception and processing mechanisms
- Child and Animal Learning Development
- Diet and metabolism studies
- Cancer Cells and Metastasis
- Congenital heart defects research
- Pelvic floor disorders treatments
- Ferroptosis and cancer prognosis
Centre National de la Recherche Scientifique
2014-2024
Laboratoire de Psychologie du Développement et de L’Education de l’enfant
2014-2024
Cyceron
2007-2024
Université Paris Cité
2014-2020
Délégation Paris 5
2014-2020
Sorbonne Paris Cité
2014-2019
Descartes (Belgium)
2017
Sorbonne Université
2017
Normandie Université
2014-2016
Université de Caen Normandie
2006-2016
In the past decade, a "default mode network" (DMN) has been highlighted in neuroimaging studies as set of brain regions showing increased activity task-free state compared to cognitively demanding task, and synchronized at rest. Changes within this network have described healthy aging well Alzheimer's disease (AD) populations risk for AD, that is, amnestic Mild Cognitive Impairment (aMCI) patients APOE-ε4 carriers. This is particular interest context early diagnosis more generally our...
Neurodevelopmental disorders affect a substantial minority of the general population. Their origins are still largely unknown, but complex interplay genetic and environmental factors causing disturbances central nervous system's maturation variety higher cognitive skills is presumed. Only limited research rather small sample size narrow scope has been conducted in neurodevelopmental using twin-differences design. The Roots Autism ADHD Twin Study Sweden (RATSS) an ongoing project targeting...
Human reasoning is often biased by heuristic thinking. A key question whether people detect that their answer conflicts with logical considerations. Empirical studies suggest the detection typically successful but generality of these findings has been questioned. The present study focuses on this issue. response confidence measure was used to validate conflict sensitivity in classical ratio bias task and identify individual differences efficiency. Participants were asked indicate how...
Autism spectrum disorder (ASD) has been found to be associated with alterations in resting state (RS) functional connectivity, including areas forming the default mode network (DMN) and salience (SN). However, insufficient control for confounding genetic environmental influences other methodological issues limit generalizability of previous findings. Moreover, it hypothesized that ASD might marked by early hyper-connectivity followed later hypo-connectivity. To date, only a few studies have...
Abstract Inhibitory control (IC) is a core executive function that enables humans to resist habits, temptations, or distractions. IC efficiency in childhood strong predictor of academic and professional success later life. Based on analysis the sulcal pattern, qualitative feature cortex anatomy determined during fetal life stable development, we searched for evidence interindividual differences partly trace back prenatal processes. Using anatomical magnetic resonance imaging (MRI), analyzed...
Females might possess protective mechanisms regarding autism spectrum disorder (ASD) and require a higher detrimental load, including structural brain alterations, before developing clinically relevant levels of autistic traits. This study examines sex differences in morphology traits using within-twin pair approach. Twin design inherently controls for shared confounders enables the gene-independent neuroanatomical variation. N = 148 twins (62 females) from 49 monozygotic 25 dizygotic...
Abstract Background Females with autism spectrum disorder have been reported to exhibit fewer and less severe restricted repetitive behaviors interests compared males. This difference might indicate sex-specific alterations of brain networks involved in symptom domains, especially within cortico-striatal sensory integration networks. study used a well-controlled twin design examine sex differences anatomy relation behaviors. Methods In 75 pairs ( n = 150, 62 females, 88 males) enriched for...
Advances in functional neuroimaging studies have led to the need for improved anatomical precision face with more and specific challenges. Nevertheless, magnetic resonance imaging (MRI) (fMRI) suffers from geometrical distortions, which limit matching between data necessary interpret fMRI results. The "FieldMap" method is most widely used technique correct distortions but some cases cannot be applied or provides unsatisfactory objective of this study thus provide a very simple alternative...
Abstract A female advantage in social cognition (SoC) might contribute to women’s underrepresentation autism spectrum disorder (ASD). The latter could be underpinned by sex differences brain structure. This study investigated the relationship between structural networks and SoC females males relation ASD autistic traits twins. We used a co-twin design 77 twin pairs (39 female) aged 12.5 31.0 years. Twin were discordant or concordant for traits, other neurodevelopmental disorders neurotypical...
ABSTRACT BACKGROUND AND PURPOSE To provide guidance regarding the most appropriate voxel-based morphometry (VBM)-derived method for assessing hippocampal atrophy in early Alzheimer's disease (AD). METHODS T1-MRI volume data were collected 23 patients with amnestic mild cognitive impairment (aMCI) and 18 controls. Three types of (unmodulated 2 modulated MRI) extraction methods (with reference to peak identified from a preliminary whole-brain analysis, or using template region...
During stress-induced increase in abdominal pressure, urinary continence is maintained by urethral closure mechanisms. Active response has been studied dogs and rats. Such an active also believed to occur humans during stress events. We aimed investigate mechanisms sneezing cats. Urethral pressures along the urethra (UP1-UP4), with microtip transducer catheters UP4 positioned distal where external sphincter (EUS) located, intravesical pressure were measured, wall, anal (AS), levator ani...
Abstract Females with autism spectrum disorder have been reported to exhibit fewer and less severe restricted repetitive behaviors interests compared males. This difference might indicate sex specific alterations of brain networks involved in symptom domains, especially within cortico-striatal sensory integration networks. study used a well-controlled twin design examine differences anatomy relation behaviors. In 75 pairs (n=150, 62 females, 88 males) enriched for (n=32), other...
Abstract Emerging evidence underscores the prenatal period's critical role in shaping later cognition and health, influenced by an intricate interplay of parental genetic environmental factors. Birth weight is commonly used as a retrospective indicator fetal development, but recent focus has shifted to more specific proxies neurodevelopment, like cortical sulcal patterns, which are established utero remain stable after birth. This study aimed elucidate interrelated effects socioeconomic...
Neuroimaging techniques have greatly diversified over the past decade. The contribution of each technique to clinical diagnosis Alzheimer's disease at a pre-dementia stage, on an individual basis, still needed be determined. present study aims comparing information provided by different neuroimaging modalities in two cases with single-domain amnestic mild cognitive impairment (MCI). Two patients MCI, P1 (71 years old, 9 education, MMSE 27, Mattis 138) and P2 (62 10 28, 137) cand 21...
ABSTRACT Females might possess protective mechanisms regarding autism spectrum disorder (ASD) and require a higher detrimental load, including structural brain alterations, before developing clinically relevant levels of autistic traits. This study examines sex differences in morphology traits using within-twin pair approach. Twin design inherently controls for shared confounders enables the gene-independent neuroanatomical variation. N=148 twins (62 females) from 49 monozygotic 25 dizygotic...