A5071375121- Endodontics and Root Canal Treatments
- Bone Metabolism and Diseases
- Dental materials and restorations
- Nanoparticles: synthesis and applications
- Bone Tissue Engineering Materials
- Bone and Dental Protein Studies
- Stress Responses and Cortisol
- Graphene and Nanomaterials Applications
- Oral and Maxillofacial Pathology
- Dental Erosion and Treatment
- Bone health and treatments
- Dental Trauma and Treatments
- Nanoparticle-Based Drug Delivery
- Clay minerals and soil interactions
- dental development and anomalies
- Anesthesia and Neurotoxicity Research
- Dental Research and COVID-19
- Grouting, Rheology, and Soil Mechanics
- Dental Anxiety and Anesthesia Techniques
- Bone Tumor Diagnosis and Treatments
- Nanotechnology research and applications
- Oral microbiology and periodontitis research
- Carbon Nanotubes in Composites
- Oral and gingival health research
- Sulfur Compounds in Biology
Hokkaido University
2016-2025
Universidad Motolinía del Pedregal
2019
Universitat de Barcelona
2015
Hokkaido University Hospital
2000
The receptor activator of NF‐kappa B ligand (RANKL) and its decoy receptor, osteoprotegerin (OPG), are the important proteins implicated in osteoclastogenesis. In this study, we investigated expressions RANKL OPG cultured human periodontal ligament (PDL) cells their roles Northern blotting revealed that mRNA was down‐regulated remarkably by application 10 −8 m one‐alpha, 25‐dihydroxyvitamin D 3 [1,25‐(OH) 2 ] −7 dexamethasone (Dex). contrast, up‐regulated same treatment. Western demonstrated...
Wnt/beta-catenin signaling plays an important role in the developing skeletal system. Our previous studies demonstrated that inhibits ability of bone morphogenetic protein (BMP)-2 to suppress myotube formation multipotent mesenchymal cell line C2C12 and this inhibition is mediated by Id1. In study, we examined intracellular BMP-2 regulating expression osteoprotegerin (OPG) receptor activator NFkappaB ligand (RANKL). OPG was induced cells osteoblastic MC3T3-E1 cells. Silencing glycogen...
Recently, one-bottle resins adhesives have been developed to reduce the number of clinical steps resin application. They are now widely used in dental practice. However, little is known regarding detailed mechanism bond degradation. Therefore, this study evaluated durability using long-term water storage testing. Resin-dentin bonded specimens were prepared five commercially available adhesives. The sectioned perpendicular adhesive interface produce beams and stored distilled for 24 hours...
This study evaluated the effect of water on dentin substrate bonding one-bottle self-etching adhesives. Dentin substrates were divided into two groups: wet and dry dentin. Wet is normal for bond testing whereas was dehydrated in a desiccator 24 hours. Bonded teeth then subgroups: stored or Microtensile strength resin to measured using three In addition, nanoleakage evaluation performed through analyses SEM TEM micrographs. The dry-dentin group significantly greater than that wet-dentin....
Pulpotomy is performed when tooth decay reaches the dental pulp or crown fractured due to trauma. Mineral trioxide aggregate (MTA) commonly used in pulpotomy, but its prognosis can be variable. N-acetyl-L-cysteine (NAC), an antioxidant amino acid, has garnered attention potential benefits. This study aimed investigate effects of MTA and NAC on pulpotomy outcomes. We Sprague Dawley rat maxillary molars perform employed Superbond C&B, MTA, mixed with (MTA–NAC) for capping. obtained tissue...
Circadian rhythm is an endogenous daily variation observed in most physiological functions including salivary secretion. Irregular lifestyle causes many diseases such as obesity and sleep disorders. The aim of this study to examine the effects timings meal on prevalence dental caries. Study was conducted at university hospital Japan. We asked 230 children (1–16 years old) record following life habits for 8 days: waking time, bedtime, mealtimes, snacking frequency, tooth brushing frequency....
Imogolite is a naturally occurring hydrous aluminosilicate clay mineral. It has nano-tubular structure similar to that of single-walled carbon nanotubes. subject interest in the pedological field, but date there been no bioapplications this substance. In study, we investigated cellular response osteoblast-like cells imogolite scaffolds. To reveal morphology, proliferation and osteoblastic functional mineralization, cultured human (Saos-2) mouse (MC3T3-E1) on The surface characteristics...
Imogolite is a naturally occurring aluminosilicate clay mineral with nanotube structure of 2 nm diameter and 60 nm-2 microm length. In this study, synthetic imogolite nanotubes were applied to cell culture the properties as scaffold compared those conventional dish carbon (CNT) scaffold. The surface characteristics drastically changed amount coated on dish. With increase concentration, morphology scaffolds from an island-like shape in random orientation self-organized fiber texture aligned...
Abstract Special AT‐rich sequence‐binding protein 2 ( SATB2 )‐associated syndrome (SAS) is characterized by alterations of SATB2. Its clinical features include intellectual disability and craniofacial abnormalities, such as cleft palate, dysmorphic features, dental abnormalities. Here, we describe three previously undiagnosed, unrelated patients with SAS who exhibited including multiple odontomas. Although isolated odontomas are common, rare. Individuals in families 1 3 underwent whole‐exome...
Osteoclasts and odontoclasts are multinucleated giant cells which resorb hard tissue by the ruffled borders. Recently, authors reported presence of a mononuclear osteoclast with border in vitro. However, its vivo has not been shown. To demonstrate odontoclast humans, present study used human deciduous teeth.After fixation decalcification, tartrate-resistant acid phosphatase (TRACPase) activity was detected azo dye method, then TRACPase-positive were observed on resorbing areas teeth. could...
Summary. Apical periodontitis after pulp therapy in a primary tooth can cause delayed eruption of the permanent successor. A case bilateral mandibular premolars is presented. The patient, 13‐year‐old girl, was referred by her dentist. Oral findings showed that right first and left second molars were retained. Other had erupted. An orthopantomogram revealed apical periodontitis, affecting both retained molars. premolar impacted against alveolar bone root premolar, there large cystic lesion...
The purpose of this study was to examine changes in functional parameters patients with anterior crossbite primary dentition during orthodontic treatment. Occlusal contact area (OCA), average bite pressure (ABP) and integrated occlusal load (IOL) were measured. Data obtained before the start treatment (period A), data when had improved B) appliance been removed C) compared. OCA showed lowest value period B, then gradually increased. ABP increased until B declined or became constant. IOL...
In this study, we examined the effects of fissure sealants on inhibition demineralization primary teeth using an automatic pHcycling system. Three were used: Teethmate F-1 2.0 (TM), BeautiSealant (BS), and Fuji III LC (IIILC). Using pH-cycling system, specimens (n=12) repeatedly demineralized remineralized. Specimens subjected to transverse microradiography (TMR), changes in integrated mineral loss (IML) lesion depth (Ld), indicated as ΔIML ΔLd, respectively, calculated. addition, fluoride...