A5049645090- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Coronary Artery Anomalies
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Dialysis and Renal Disease Management
- Innovative Teaching and Learning Methods
- Parathyroid Disorders and Treatments
- Evaluation of Teaching Practices
- Fiber-reinforced polymer composites
- Vocational Education and Training
- Educational Strategies and Epistemologies
- Pharmacology and Obesity Treatment
- Cardiovascular Effects of Exercise
- Respiratory Support and Mechanisms
- Vascular anomalies and interventions
- Education Methods and Technologies
- Innovative Teaching Methods
- Recycling and Waste Management Techniques
- Education, Achievement, and Giftedness
- Diabetes Management and Research
- Cardiovascular and Diving-Related Complications
- Obesity and Health Practices
Heidelberg University
2021-2025
Erasmus MC
2014-2024
Netherlands Heart Institute
2017-2024
Erasmus MC - Sophia Children’s Hospital
2017-2023
Radboud University Nijmegen
2014
Radboud University Medical Center
2014
Fraunhofer Institute for Chemical Technology
2009
<ns4:p>Tetralogy of Fallot (ToF) is the most common type cyanotic congenital heart disease. Since first surgical repair in 1954, treatment has continuously improved. The strategies currently used ToF result excellent long-term survival (30 year ranges from 68.5% to 90.5%). However, residual problems such as right ventricular outflow tract obstruction, pulmonary regurgitation, and (ventricular) arrhythmia are often require re-interventions. Right dysfunction can be seen following longstanding...
Cardiovascular disease (CVD) is the leading cause of death among chronic kidney (CKD) patients. Vascular calcification highly prevalent in this population and an independent predictor cardiovascular mortality. uraemic patients known to be active regulated process subject action many promoting inhibitory factors. The role vitamin D remains controversial. We evaluated relationship between serum levels 25-hydroxyvitamin (25(OH)D) vascular by plain X-ray images, predialysis with CKD stages 4...
The surgical approach to repair of tetralogy Fallot (ToF) has shifted over the years. We aimed report long-term follow-up after ToF with transatrial–transpulmonary and determine predictors outcomes. Retrospective analysis patients operated on in two tertiary referral centres. Primary outcome measures were: death, pulmonary valve replacement (PVR), reintervention for other reasons, internal cardiodefibrillator and/or pacemaker placement. Kaplan–Meier assessment overall event-free survival as...
<ns4:p>In patients with a functionally univentricular heart, the Fontan strategy achieves separation of systemic and pulmonary circulation reduction ventricular volume overload. Contemporary modifications surgical techniques have significantly improved survival. However, resulting physiology is associated high morbidity. In this review, we discuss state art by assessing survival risk factors for mortality. Complications circulation, such as cardiac arrhythmia, thromboembolism, protein-losing...
Background Patients who have undergone the Fontan procedure are at high risk of circulatory failure. In an exploratory analysis we aimed to determine prognostic value blood biomarkers in a young cohort procedure. Methods and Results multicenter prospective studies patients underwent sampling, cardiopulmonary exercise testing, stress cardiac magnetic resonance imaging. Several including NT-proBNP (N-terminal pro-B-type natriuretic peptide), GDF-15 (growth differentiation factor 15), Gal-3...
Abstract: Challenges for university students were high during distance education in lockdowns due to the COVID-19 pandemic. Self-regulation and motivation became more important, but was possibly challenged more. To investigate motivational differences possible positive effects of evidence-based learning activities, we followed two cohorts preservice teachers over course one semester: One cohort 2019 a face-to-face semester ( N = 225), another 1 year later first lockdown 2020 311). Students...
Zusammenfassung: Bereiten sich Schülerinnen ineffizienter auf Klausuren vor als Schüler? Dem vorherrschenden Geschlechtsstereotyp zufolge sind Mädchen fleißig, gewissenhaft und strebsam. In der vorliegenden Studie wird die Annahme geprüft, dass ihre Lernzeit im Vergleich zu Schülern häufiger mit Anwendung ineffektiver Lerntechniken verbringen. Zudem untersucht, ob über das biologische Geschlecht hinaus ein feminines Geschlechtsrollen-Selbstkonzept Nutzung erklärt. Zu diesem Zweck wurden N =...
Abstract OBJECTIVES Our goal was to report the long-term serial follow-up after transatrial–transpulmonary repair of tetralogy Fallot (TOF) and describe influence timing on outcome. METHODS We included all patients with TOF who had undergone between 1970 2012. Records were reviewed for patient demographics, operative details events during period (death, pulmonary valve replacement, cardiac reinterventions hospitalization/intervention arrhythmias). In elective early primary 1990, a...
ObjectiveTo assess the role of atrial function on exercise capacity and clinical events in Fontan patients.DesignWe included 96 patients from 6 tertiary centers, aged 12.8 (IQR 10.1–15.6) years, who underwent cardiac magnetic resonance imaging cardiopulmonary testing within 12 months each other 2004 to 2017. Intra-atrial lateral tunnel (ILT) extracardiac conduit (ECC) were matched 1:1 with regard age, gender dominant ventricle.The pulmonary venous atrium was manually segmented all phases...
To determine the potential prognostic value and clinical correlations of blood biomarkers in a cohort patients with Tetralogy Fallot (TOF).In setting multicenter prospective research studies TOF underwent sampling, cardiopulmonary exercise testing low-dose dobutamine stress cardiac magnetic resonance (CMR) imaging. In sample NT-proBNP, GDF-15, Galectin-3, ST-2, DLK-1, FABP4, IGFBP-1, IGFBP-7, MMP-2, vWF were assessed. During subsequent follow-up, evaluated for reaching study endpoint...
Patients after surgical correction of Tetralogy Fallot (ToF) often show adverse cardiac remodelling. To better understand the underlying biological processes, we studied relation between changes in blood biomarkers and biventricular size function as assessed by magnetic resonance imaging (CMR). This study included 50 ToF patients, who underwent biomarker CMR analysis at least twice 2002 2018. 34 (68%) these patients were male. had an average age 16.1 first visit. Biomarkers chosen based on...
Abstract Aims The aim of this study was to evaluate the possible value dobutamine stress cardiac magnetic resonance imaging (CMR) predict adverse outcome in Tetralogy Fallot (TOF) patients. Methods and results In previous prospective multicentre studies, TOF patients underwent low-dose CMR (7.5 µg/kg/min). Subsequently, during regular-care patient follow-up, were assessed for reaching composite endpoint (cardiac death, arrhythmia-related hospitalization, or cardioversion/ablation, VO2 max...
Objective Cardiac surgery may cause temporarily impaired ventricular performance and myocardial injury. We aim to characterise the response perioperative injury for patients undergoing repair or pulmonary valve replacement (PVR) tetralogy of Fallot (ToF). Methods enrolled children ToF PVR from four tertiary centres in a prospective observational study. Assessment—including blood sampling speckle tracking echocardiography—occurred before (T1), at first follow-up (T2) 1 year after procedures...
Our goals were to compare the outcome of intra-atrial lateral tunnel (ILT) and extracardiac conduit (ECC) techniques for staged total cavopulmonary connection (TCPC) current modifications TCPC technique, i.e. prosthetic ILT technique with ECC a ≥18-mm conduit.We included patients who had undergone between 1988 2008. Records reviewed patient demographics, operative details events during follow-up (death, surgical catheter-based reinterventions arrhythmias).Of 208 included, 103 (51 baffle, 52...
To assess the atrial and ventricular diastolic function response to dobutamine stress in Fontan patients, relate these measurements exercise capacity events during follow-up. We performed a secondary analysis of cross-sectional multicentre study patients with intra-atrial lateral tunnel (ILT) or extracardiac conduit (ECC) modification. Subjects underwent cardiac MRI rest low-dose stress, cardiopulmonary testing. Atrial parameters were derived from volume-time curves.Medical records...
This study compared university students' motivational development and learning success during multiple regular pandemic distance semesters. In general, a decline in expectancies task values was expected Based on situated expectancy-value theory, we exploratively examined how situative pandemic-related factors were related to development, knowledge acquisition, ceased self-testing. Data from N = 690 students attending the same lecture course educational psychology assessed four (n 426) three...
Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): Dutch Heart Foundation Background Ventricular performance is temporarily reduced following surgical atrial septal defect (ASD) closure. Cardiopulmonary bypass and changes in loading conditions are considered important factors, but this phenomenon incompletely understood. We aim to characterize biventricular percutaneous ASD closure relate biomarkers ventricular intervention. Methods In multicenter...
Background Ventricular performance is temporarily reduced following surgical atrial septal defect closure. Cardiopulmonary bypass and changes in loading conditions are considered important factors, but this phenomenon incompletely understood. We aim to characterize biventricular percutaneous closure relate biomarkers ventricular intervention. Methods Results In multicenter prospective study, children scheduled for or were included. Subjects assessed preoperatively, the second week...