A5033653473- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Metabolism and Genetic Disorders
- Cardiac Arrhythmias and Treatments
- Mitochondrial Function and Pathology
- Cardiac Valve Diseases and Treatments
- Cardiovascular Issues in Pregnancy
- Cardiovascular Effects of Exercise
- Advanced MRI Techniques and Applications
- Adipose Tissue and Metabolism
- Neonatal Respiratory Health Research
- Cardiac pacing and defibrillation studies
- Coronary Artery Anomalies
- Heart Failure Treatment and Management
- Birth, Development, and Health
- Diet and metabolism studies
- Cardiac Arrest and Resuscitation
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Cardiovascular and exercise physiology
- Peptidase Inhibition and Analysis
- Peroxisome Proliferator-Activated Receptors
- Vascular Anomalies and Treatments
Erasmus MC
2017-2025
Erasmus MC - Sophia Children’s Hospital
2017-2025
University of Groningen
2013-2022
University Medical Center Groningen
2012-2022
Erasmus University Rotterdam
2021
Adult Congenital Heart Association
2018
Pediatrics and Genetics
2018
Beatrix Kinderziekenhuis
2007-2017
Leiden University Medical Center
2013
Gujarat Institute of Desert Ecology
2009
Rationale: Pulmonary arterial hypertension (PAH) is a degenerative arteriopathy that leads to right ventricular (RV) failure. BRD4 (bromodomain-containing protein 4), member of the BET (bromodomain and extra-terminal motif) family, has been identified as critical epigenetic driver for cardiovascular diseases.Objectives: To explore therapeutic potential in PAH RVX208, clinically available inhibitor.Methods: Microvascular endothelial cells, smooth muscle cells isolated from distal pulmonary...
The transition from reversible to irreversible pulmonary arterial hypertension involves vascular senescence and can be countered by senolysis.
Background— The value of echocardiography in assessing disease severity and predicting outcome pediatric pulmonary arterial hypertension (PAH) is insufficiently defined. aim this study was to describe correlations between PAH. Methods Results— Forty-three consecutive children (median age, 8.0 years; range, 0.4–21.5) with idiopathic/hereditary PAH (n=25) or associated congenital heart (n=18) were enrolled a prospective single-center observational study. Anatomic right ventricular-functional...
Risperidone is the most commonly prescribed antipsychotic drug to children and adolescents worldwide, but it associated with serious side effects, including weight gain. This study assessed relationship of risperidone 9-hydroxyrisperidone trough concentrations, maximum concentrations 24-hour area under curves (AUCs) body mass index (BMI) z-scores in autism spectrum disorder (ASD) behavioural problems. Secondary outcomes were metabolic, endocrine, extrapyramidal cardiac effects...
Lactate accounts for a third of myocardial oxygen consumption before and in the first 2 weeks after birth. It is unknown how remainder consumed. Glucose thought to be important birth, whereas long-chain fatty acids (LC-FA) are prime substrate adult. However, ability myocardium newborn use LC-FA has been doubted.We measured metabolism glucose with [U-(13)C]glucose [1-(13)C]palmitate chronically instrumented fetal lambs. In lambs, oxidation was high that low. accounted 48+/-4% 2+/-2%...
<h3>Background</h3> Pulmonary arterial hypertension (PAH) is a commonly fatal pulmonary vascular disease that often diagnosed late and characterised by progressive rise in resistance resulting from typical remodelling. Recent data suggest damage plays an important role the development of radiation-induced toxicity. Therefore, authors investigated whether irradiation lung also induces hypertension. <h3>Methods</h3> Different sub-volumes rat were irradiated with protons known to induce...
Right ventricular (RV) failure due to chronically abnormal loading is a main determinant of outcome in pulmonary hypertension (PH) and congenital heart disease. However, distinct types RV have been associated with different outcomes. To determine whether the adaptive response depends on type, we compared hemodynamics, exercise, hypertrophy models pressure overload artery banding (PAB), PH, combined volume overload, isolated load. Ninety-four rats were subjected either PAB,...
Background Patients who have undergone the Fontan procedure are at high risk of circulatory failure. In an exploratory analysis we aimed to determine prognostic value blood biomarkers in a young cohort procedure. Methods and Results multicenter prospective studies patients underwent sampling, cardiopulmonary exercise testing, stress cardiac magnetic resonance imaging. Several including NT-proBNP (N-terminal pro-B-type natriuretic peptide), GDF-15 (growth differentiation factor 15), Gal-3...
<h3>Objective</h3> In paediatric pulmonary arterial hypertension (PAH), the effectiveness of add-on combination PAH-therapy has not yet been systematically studied. The purpose this study was to determine effect sildenafil therapy in PAH patients treated with bosentan. <h3>Methods</h3> observational within a national patient cohort, follow-up data 24 consecutive initially bosentan monotherapy and prospectively followed at Dutch referral centre for 2007–2013, were reviewed. Patients received...
Rationale: The development of evidence-based treatment guidelines for pediatric pulmonary arterial hypertension (PAH) is hampered by lack clinical trials. Trial design a feasible endpoint in this population.Objectives: To evaluate the use accelerometry measuring physical activity (PA) PAH and to investigate its correlation with disease severity markers.Methods: We included children from Dutch National Network Pediatric Pulmonary Hypertension. Control patients were recruited outpatient...
Right ventricular (RV) function is an important determinant of prognosis in congenital heart diseases, pulmonary hypertension, and failure. Preventive sildenafil treatment has been shown to enhance systolic RV improve exercise capacity a model fixed pressure load. However, it unknown whether beneficial effects when started established dysfunction, which clinically more relevant. Our aim was assess the on fibrosis dysfunction due afterload. Rats were subjected artery banding (PAB), induced...
Bronchopulmonary dysplasia (BPD) is the most common complication in preterm infants and often complicated by pulmonary hypertension (PH), leading to substantial morbidity mortality. Sildenafil used treat PH improve symptoms this condition, even though evidence of safety effectiveness scarce. The aim study was perform a systematic review meta‐analysis about chronic use sildenafil with BPD‐associated PH. Data sources were PubMed, EMBASE, Medline. Studies reporting therapy newborns included....