A5053881356- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Nerve injury and regeneration
- Silk-based biomaterials and applications
- Carbon Nanotubes in Composites
- Diabetes and associated disorders
- Porphyrin and Phthalocyanine Chemistry
- Carbohydrate Chemistry and Synthesis
- Diamond and Carbon-based Materials Research
- Receptor Mechanisms and Signaling
- Food Industry and Aquatic Biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Transportation Systems and Logistics
- Pancreatic function and diabetes
Macquarie University
2022-2025
ARC Centre of Excellence in Synthetic Biology
2024
Metabolic diseases such as obesity and type 2 diabetes are marked by insulin resistance
The mammalian glycome is structurally complex and diverse, composed of many glycan classes such as N- O-linked glycans, glycosaminoglycans (GAGs), glycosphingolipids (GSLs), other distinct features polysialic acids (PolySia), sulfation, proteoglycan attachment stubs. Various methods are used to analyze these different components the glycome, but they require prefractionated/partitioned samples target each class individually. To address this need for a knowledge relationship between...
Chondroitin sulphate (CS) is a sulphated glycosaminoglycan (GAG) polysaccharide found on proteoglycans (CSPGs) in extracellular and pericellular matrices. Chondroitinase ABC (CSase ABC) derived from Proteus vulgaris an enzyme that has gained attention for the capacity to cleave chondroitin glycosaminoglycans various such as Aggrecan, Neurocan, Decorin etc. The substrate specificity of CSase well-known targeting structural motifs CS chains popularity field neuro-regeneration by selective...
Nanodiamonds were coated in lectins to target glycan receptors on astrocytes, neurons and microglia. The uptake each cell type was variable depending their coating of Aleuria aurantia lectin, wheat germ agglutinin or tomato lectin.
<title>Abstract</title> Chondroitin sulphate (CS) is a sulphated glycosaminoglycan (GAG) polysaccharide found on proteoglycans (CSPGs) in extracellular and pericellular matrices. Chondroitinase ABC (CSase ABC) derived from <italic>Proteus vulgaris</italic> an enzyme that has gained attention for the capacity to cleave chondroitin sulfate glycosaminoglycans various such as Aggrecan, Neurocan, Decorin etc. The substrate specificity of CSase well-known targeting structural motifs CS chains...