A5061067218- Gut microbiota and health
- Chronic Kidney Disease and Diabetes
- Probiotics and Fermented Foods
- Peripheral Artery Disease Management
- Liver Disease Diagnosis and Treatment
- Listeria monocytogenes in Food Safety
- Venous Thromboembolism Diagnosis and Management
- Dialysis and Renal Disease Management
- Vasculitis and related conditions
- Liver Disease and Transplantation
- Systemic Sclerosis and Related Diseases
- Metabolomics and Mass Spectrometry Studies
- Otitis Media and Relapsing Polychondritis
- MRI in cancer diagnosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Clostridium difficile and Clostridium perfringens research
- Diagnosis and Treatment of Venous Diseases
- Porphyrin Metabolism and Disorders
- Hematopoietic Stem Cell Transplantation
- Anesthesia and Pain Management
- Bone and Joint Diseases
- Transplantation: Methods and Outcomes
- Parathyroid Disorders and Treatments
- Urticaria and Related Conditions
- Dermatological and Skeletal Disorders
University of Regensburg
2015-2016
Institute of Medical Microbiology and Hygiene
2016
SRH Klinikum Karlsbad-Langensteinbach
2008
Heidelberg University
1995
Next-generation 16S ribosomal RNA gene sequencing is widely used to determine the relative composition of mammalian gut microbiomes. However, in absence a reference, this does not reveal alterations absolute abundance specific operational taxonomic units if microbial loads vary across specimens.Here we suggest spiking exogenous bacteria into crude specimens quantify ratios bacterial abundances. We use rDNA read counts spike-in adjust endogenous for changes total loads. Using series dilutions...
In biomedicine, every molecular measurement is relative to a reference point, like fixed aliquot of RNA extracted from tissue, defined number blood cells, or volume biofluid. Reference points are often chosen for practical reasons. For example, we might want assess the metabolome diseased organ but can only measure metabolites in urine. this case, observable data indirectly reflects disease state. The statistical implications these discrepancies have not yet been discussed.Here, show that...
Abstract Background Altered hemodynamics in liver disease often results overestimation of glomerular filtration rate (GFR) by creatinine-based GFR estimating (eGFR) equations. Recently, we have validated a novel eGFR equation based on serum myo-inositol, valine, and creatinine quantified nuclear magnetic resonance spectroscopy combination with cystatin C, age sex (GFR NMR ). We hypothesized that could improve chronic kidney (CKD) classification the setting disease. Results conducted...
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Assessment of renal function relies on the estimation glomerular filtration rate (eGFR). Existing eGFR equations, usually based serum levels creatinine and/or cystatin C, are not uniformly accurate across patient populations. In present study, we expanded a recent proof-of-concept approach to optimize an equation targeting adult population with and without chronic kidney disease (CKD), nuclear magnetic resonance spectroscopy (NMR) derived 'metabolite constellation' (GFR
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Accurate and precise monitoring of kidney function is critical for a timely reliable diagnosis chronic disease (CKD). The determination usually involves the estimation glomerular filtration rate (eGFR). We recently reported clinical performance new eGFR equation (GFRNMR) based on nuclear magnetic resonance (NMR) measurement serum myo-inositol, valine, creatinine, in addition to immunoturbidometric quantification cystatin C, age sex. now describe analytical evaluation GFRNMR according...
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
A 57-year-old woman, a heavy smoker and migraine sufferer, was admitted with severe resting pain in the right forefoot painful localized tendril-shaped reddening on thigh. She had regularly been taking 1-2 mg ergotamine tartrate, several analgesics, some containing caffeine, selective serotonin-uptake inhibitors. Clinical examination found all limbs to be cool. On leg pulse not palpable below inguinal line, corresponded livedo.The peripheral Doppler pressure indicated critical perfusion...
Close monitoring of glomerular filtration rate (GFR) is essential for the management patients post kidney transplantation. Measured GFR (mGFR), gold standard, not readily accessible in most centers. Furthermore, performance new estimated (eGFR) equations based upon creatinine and/or cystatin C have been validated transplant patients. Here we evaluate a recently published eGFR equation using C, creatinine, myo-inositol and valine as measured by nuclear magnetic resonance (eGFRNMR).Residual...
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
A 63-year-old man, known to have Bechterev's disease was admitted because of weight gain and nocturnal sweating. He also had signs heart failure with progressive exertional dyspnoea. Many months previously numerous bleedings occurred in the skin, predominantly face (periorbital perioral), inguinal region penis.Extensive diagnostic test failed find any evidence tumor. The Rumpel-Leede tourniquet positive, while platelet functions normal, suggesting vascular disease. skin biopsy showed many...