A5086452520- Synthesis of Organic Compounds
- Mosquito-borne diseases and control
- Phytochemical compounds biological activities
- Insect symbiosis and bacterial influences
- Viral Infections and Vectors
- Hepatitis C virus research
- Cytokine Signaling Pathways and Interactions
- Carbohydrate Chemistry and Synthesis
- Fungal Plant Pathogen Control
- Retinoids in leukemia and cellular processes
- Plant Pathogens and Fungal Diseases
- interferon and immune responses
- Fungal Infections and Studies
- Hepatitis B Virus Studies
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- Chemical Synthesis and Analysis
- Multicomponent Synthesis of Heterocycles
- Nail Diseases and Treatments
- Protein Degradation and Inhibitors
- HIV/AIDS drug development and treatment
- Synthetic Organic Chemistry Methods
- Oxidative Organic Chemistry Reactions
Brooklyn College
2017-2023
City University of New York
2017-2023
The Graduate Center, CUNY
2017-2023
Weatherford College
2017
Cryptococcus neoformans is a pathogen that common in immunosuppressed patients. It can be treated with amphotericin B and fluconazole, but the mortality rate remains 15 to 30%. Thus, novel more effective anticryptococcal therapies are needed. The troponoids based on natural products isolated from western red cedar, have broad range of antimicrobial activities. Extracts cedar inhibit growth several fungal species, neither extracts nor troponoid derivatives been tested against C. We screened...
A new 3,7-dihydroxytropolone synthetic strategy provides access to a proposed natural product precursor and potent antiviral compounds.
Rift Valley fever virus (RVFV) is a veterinary and human pathogen an agent of bioterrorism concern. Currently, RVFV treatment limited to supportive care, so new drugs control infection are urgently needed. member the order Bunyavirales , whose replication depends on enzymatic activity viral L protein. Screening for inhibitors among compounds with divalent cation-coordinating motifs similar known nuclease identified 47 novel selective indexes from 1.1–103 50% effective concentrations 1.2–56...
Lipophilic side-chains enhance αHT antiviral potency.
Herein, we describe the formation of tropolones through autoxidation Büchner reaction-derived cycloheptatrienes. The reaction is exceptionally simple procedurally, as it involves blowing a stream compressed air over cycloheptatriene, and products can be obtained without any need for chromatography. chemistry works specifically on dioxolane-fused systems or close variants, substitution patterns are also important. A radical-based mechanistic hypothesis put forward to explain these results....
α-Hydroxytropolones (αHTs) have potent antiviral activity against herpes simplex virus-1 and -2 (HSV-1 HSV-2) in cell culture, including acyclovir-resistant mutants, as a result the potential to be developed drugs targeting these viruses. We recently described convenient final-step amidation strategy their synthesis, this was used generate 57 amide-substituted αHTs that were tested hepatitis B virus. The following manuscript describes evaluation of library HSV-1, well subset HSV-2....
Abstract Rift Valley Fever Virus (RVFV) is a veterinary and human pathogen an agent of bioterrorism concern. Currently, RVFV treatment limited to supportive care, so new drugs control infection are urgently needed. member the Bunyavirales order, replication these viruses depends on viral endonuclease activity L protein. Screening for inhibitors among compounds with divalent cation-coordinating motifs similar known nuclease identified 31 novel selective indexes from 5 – 402 50% effective...