A5027442585- Cervical Cancer and HPV Research
- Pregnancy and Medication Impact
- HIV/AIDS Research and Interventions
- Drug Transport and Resistance Mechanisms
- Science and Education Research
- Reproductive tract infections research
- Adolescent Sexual and Reproductive Health
- Pharmacological Effects and Toxicity Studies
- Mosquito-borne diseases and control
- Hepatitis B Virus Studies
- Women's cancer prevention and management
- Genital Health and Disease
- Curcumin's Biomedical Applications
- HIV/AIDS drug development and treatment
- Pregnancy and preeclampsia studies
- Sexual Assault and Victimization Studies
- HIV-related health complications and treatments
- T-cell and Retrovirus Studies
- Reproductive Health and Contraception
- Global Maternal and Child Health
- Syphilis Diagnosis and Treatment
- Sex work and related issues
- Immune Response and Inflammation
- Phytochemical compounds biological activities
- NF-κB Signaling Pathways
Universidade de São Paulo
2009-2025
Clinics Hospital of Ribeirão Preto
2016-2024
Universidade de Ribeirão Preto
2017-2023
Hospital Universitário da Universidade de São Paulo
2018
HPV have been identified as high-risk and low-risk, depending on their association with the development of cancer. infections can be facilitated by co-infection HIV. Here, we investigated prevalence genotypes risk factors affecting HPV/HIV co-infection. Forty HIV-positive patients had 80 cervical swab samples collected in 2 consecutive years. Polymerase chain reaction DNA direct sequencing were used to perform genotyping. Statistical analyses performed regarding for occurrence lesions. was...
Vulvar intraepithelial neoplasia (VIN) is associated with human papillomavirus (HPV) infection. Curcumin a natural bioactive compound antineoplastic properties. The use of nanoparticles containing curcumin could allow better performance this in therapies. So, VIN biopsies were collected and HPV DNA detection was performed by PCR, positive samples genotyped Restriction Fragment Length Polymorphism (RFLP) HPV-16 variants determined sequencing. vulva carcinoma cells (A431) transduced E-P E-350G...
This study evaluates the impact of acute pyelonephritis in pregnant women on vivo activity renal OAT3 using endogenous biomarker (EB) 6β-hydroxycortisol (6β-OHF) clearance (CLrenal 6β-OHF) and AUC6β-OHF validated by correlating with secretion (CLsec) probe drug furosemide. Additionally, 6β-OHF formation (CLformation as well urinary (Ae6β-OHF/AeF) plasma (AUC6βOHF/AUCF) ratios were also evaluated EB for hepatic CYP3A activity. Pregnant their third trimester gestation, diagnosed...
We report 2 fatal cases of congenital Zika virus (ZIKV) infection. Brain anomalies, including atrophy the cerebral cortex and brainstem, cerebellar aplasia were observed. The spinal cord showed architectural distortion, severe neuronal loss, microcalcifications. ZIKV proteins flavivirus-like particles detected in cytoplasm neurons, samples positive for RNA.
To evaluate the assistance provided to women victims of sexual violence and their participation in follow-up treatment after traumatic event, presenting a sociodemographic profile, gynecological background, circumstances reporting results, acceptance, side effects prophylaxis for sexually transmitted infections (STIs) pregnancy. A retrospective cohort study comprising period between 2007 2016. All receiving medical care clinical severe episode were included. Records domestic violence, male...
HPV persistence is a key determinant of cervical carcinogenesis. The influence postpartum on clearance has been debated. This study aimed to assess in later pregnancy and among HIV-positive negative women. We conducted follow-up with 151 HPV-positive women coinfected HIV, 2007–2010. After baseline assessment, all were retested for infection using PCR after delivery. Multivariable logistic regressions assessed the putative association covariates status between each one successive visits....
Objective . To estimate HPV prevalence among pregnant women from Ribeirão Preto, Brazil, and the possible influence of HIV-1 infection on this prevalence. Methods A cross-sectional study with 44 HIV-positive 53 HIV-negative was conducted. Cervicovaginal specimens were obtained all during gynecologic exam. DNA, low high risk types, detected using conventional PCR. Statistical analysis used Student's<mml:math...
Abstract This study evaluates the influence of pregnancy and HIV infection in conjunction with use raltegravir, lamivudine, tenofovir disoproxil fumarate (combined antiretroviral therapy [cART]) on intestinal P‐glycoprotein (P‐gp) hepatic organic anion transporter polypeptide (OATP) 1B1/1B3 and/or breast cancer resistance protein (BCRP) drug activity using rosuvastatin (OATP1B/BCRP) fexofenadine probes. Single oral doses 5‐mg 60‐mg were administered to women living under cART third trimester...
Inflammation can regulate hepatic drug metabolism enzymes and transporters. The impact of inflammation on renal transporters remains to be elucidated. We aimed quantify the effect (caused by acute pyelonephritis) in vivo activity OAT1/3, using probe furosemide. Pregnant women (second or third trimester) received a single oral dose furosemide 40 mg during pyelonephritis (Phase 1; n = 7) after its resolution 2; 7; treatment with intravenous cefuroxime 750 TID for 3–7 days), separated 10 14...
This study investigates the influence of pregnancy on in vivo activity intestinal P-glycoprotein (P-gp) and hepatic organic anion transporters polypeptide (OATP/BCRP) using, respectively, fexofenadine rosuvastatin as probe drugs. Eleven healthy participants were investigated during third trimester (Phase 1, 28 to 38 weeks gestation) postpartum period 2, 8 12 postpartum). In both phases, after administration a single oral dose (60 mg) (5 mg), serial blood samples collected for up 24 h....
Modelo do estudo: transversal. Objetivo verificar o conhecimento de mulheres atendidas em dois ambulatórios Ginecologia e Obstetrícia sobre Papiloma Vírus Humano (HPV). Metodologia: foram utilizados dados secundários um banco eletrônico que as informações coletadas por meio questionário no período 2007 a 2012. Resultados: incluídas 1.470 com média idade 30,7 anos. Dentre mulheres, 51,0% já haviam ouvido falar HPV, porém, apenas 41,6% sabiam da transmissão sexual 33,3% relação patógeno câncer...
Background Studies addressing neuroimaging findings as primary outcomes of congenital Zika virus infection are variable regarding inclusion criteria and confirmatory laboratory testing. Purpose To investigate cranial US signs prenatal exposure to describe frequencies in infants exposed compared those control infants. Materials Methods In this single-center prospective cohort study, participants were enrolled during the December 2015-July 2016 outbreak southeast Brazil (Natural History Virus...
Abstract Objective To evaluate the seroprevalence of toxoplasmosis among puerperal women cared for at a tertiary university hospital and level understanding these about toxoplasmosis, vertical transmission, its prophylaxis. Methods For this cross-sectional study, we evaluated 225 patients using presential interviews, prenatal documentation, electronic medical records. Data were stored Research Electronic Capture (REDCap) software. Prevalence rates estimated by presence reactive IgG...
Condyloma acuminata (CA) is a benign proliferative disease mainly affecting in non-keratinized epithelia. Most cases of CA are caused by low-risk human papillomavirus (HPV), HPV 6 and 11. The aim the current study was to highlight candidate genes pathways associated with immune alterations individuals who did not spontaneously eliminate virus and, thus, develop genital warts. Paraffin-embedded condyloma samples (n = 56) were analyzed immunohistochemistry using antibodies against CD1a, FOXP3,...
This work aimed to evaluate the total, unbound, renal, and hepatic clearances of raltegravir (RAL) formation elimination glucuronide (RAL GLU) in pregnant women living with HIV. The participants received RAL 400 mg twice daily during third trimester (n = 15) gestation, delivery 15), postpartum period 8). Pharmacokinetic parameter values were calculated on basis plasma urine data using noncompartmental methods. for gestation as follows: total clearance: geometric mean, 63.63 L/h (95% CI,...
Inflammation can regulate hepatic drug metabolism enzymes and transporters. The impact of inflammation on renal transporters remains to be elucidated. We aimed quantify the effect (caused by acute pyelonephritis) in vivo activity OAT1/3, using probe furosemide. Pregnant women (2nd or 3rd trimester) received a single oral dose furosemide 40 mg during pyelonephritis (Phase 1; n = 7) after its resolution 2; 7; treatment with intravenous cefuroxime 750 TID for 3-7 days), separated 10 14 days....
Condyloma acuminata (CA), or genital warts, are benign proliferative epidermal mucous lesions that caused by infection with human papillomavirus (HPV), mainly the low-risk types 6 and 11. HPV variants defined as viral sequences share identity in nucleotide sequence of L1 gene greater than 98%. Based on this criterion, HPV6 11 variant lineages have been studied, there ongoing attempts to correlate these genetic different clinical findings infection. Therefore, aims study were detect...
<b><i>Introduction:</i></b> Persistent infection with high-risk human papillomavirus (HPV) types is associated high-grade intraepithelial lesions (HSILs) and invasive cervical cancer. The host immune response plays a key role in whether HPV clears or persists. Most studies on local to collect mucus order quantify secreted cytokines; however, cells located inside the tissue can release different cytokines infection. <b><i>Objective:</i></b> This...
Introdução: É importante identificar características de gestantes infectadas pelo HIV para elaborar ações melhoria da assistência a essas mulheres. Objetivo: o objetivo do estudo foi caracterizar as vírus imunodeficiência humana (HIV) atendidas em ambulatório moléstias infectocontagiosas obstetrícia no município Ribeirão Preto-SP. Materiais e Métodos: realizado um tipo corte transversal período 2010 2012 utilizando-se dados secundários prontuários médicos. Resultados: foram incluídas 113 com...
•Although congenital syphilis has a known etiological agent, accessible diagnosis and low-cost, effective treatment with low fetal toxicity, it continues to challenge obstetric antenatal care services. •The increasing rates of in the general population have direct repercussions on increase cases syphilis, situation objective interest for public health. transforming recording into notifiable diseases improved records made possible measure occurrence these create solutions, no effects reducing...
Increasing genetic diversity of HIV-1 and emergence drug-resistant mutations may reduce the efficacy antiretroviral therapy prophylaxis that are used to prevent mother-to-child transmission. The aim this study was assess prevalence among HIV-infected pregnant women.Cross-sectional at an outpatient clinic for infectious diseases within gynecology obstetrics.This evaluated dynamics subtypes transmitted acquired 38 women (20 previously exposed 18 naive), in Ribeirão Preto (SP), Brazil, between...