A5016074190- Pharmaceutical Economics and Policy
- Medication Adherence and Compliance
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Hemoglobinopathies and Related Disorders
- Pharmaceutical Practices and Patient Outcomes
- Iron Metabolism and Disorders
- Hip and Femur Fractures
- Bone health and osteoporosis research
- Antiplatelet Therapy and Cardiovascular Diseases
- Bone health and treatments
- Tuberculosis Research and Epidemiology
- Retinal Diseases and Treatments
- Parathyroid Disorders and Treatments
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Retinal Imaging and Analysis
- Genetic and Kidney Cyst Diseases
- Diabetes Treatment and Management
- Multiple Sclerosis Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Disease Management Strategies
- Vasculitis and related conditions
- Myasthenia Gravis and Thymoma
Health Economics and Outcomes Research (United Kingdom)
2006-2025
Center for Outcomes Research and Clinical Epidemiology
2007-2020
Local Government Association
2018
Istituto Ortopedico Rizzoli
2002
Abstract Background Respiratory syncytial virus (RSV) is among the leading causes of hospitalization due to lower respiratory tract infections (LRTIs) in children younger than 5 years worldwide and second cause infant death after malaria. RSV infection occurs almost all infants before year life with variable clinical severity, often requiring medical assistance. This analysis investigated patients aged 0–5 focusing on epidemiology, features, economic burden RSV-associated hospitalizations a...
Background/Objectives The economic impact of respiratory syncytial virus (RSV) in Italy is not well defined. This analysis assessed the outcomes RSV-hospitalized patients aged ≥ 60 years Italy. Methods: Healthcare resource utilization and direct healthcare costs during first RSV hospitalization 12-month follow-up were collected from Italian administrative databases. A propensity-score-matched (PSM) was performed between hospitalized for those any cause (without an diagnosis). Results: Among...
The prescription of non-steroidal anti-inflammatory drugs (NSAIDs) covered by the Italian National Health Service is limited to certain pathologies defined in 2018 update Note 66 Medicines Agency (AIFA), meant ensure appropriate use NSAIDs. This analysis was conducted real clinical practice describe NSAID utilization from 2019 2022 with respect update. For this real-world analysis, data were extracted administrative databases healthcare institutions covering ~ 9.1 million citizens. From...
Background Evidence regarding the relationships among high plasma triglycerides (TG), all‐cause mortality, and atherosclerotic cardiovascular disease (ASCVD) events in low‐to‐moderate risk individuals is limited. The aim of this study was to determine whether presence TG levels influences mortality ASCVD a population cohort followed real‐world clinical setting. Methods Results A retrospective longitudinal analysis using administrative databases 3 Italian Local Health Units performed. All...
To evaluate and compare the incidence of cardiovascular (CV) events in a large contemporary cohort patients diagnosed with prostate cancer (PCa) treatment GnRH agonists or antagonists.An Italian observational retrospective study based on administrative databases three local health units two Regions was performed. PCa treated antagonist were included between January 01, 2013 December 31, 2016. Index date (ID) first agonist/antagonist prescription during inclusion period. Follow-up from ID to...
The purpose of this study was to investigate the epidemiology, management, and economic burden myasthenia gravis in settings real clinical practice. analysis used administrative databases covering around 12 million subjects across Italy included all adult patients with hospitalization discharge diagnosis or active exemption code for ≥1 pyridostigmine prescription from 2011 2018. estimated prevalence during 2018 range 13.5-29.3/100,000 people (depending on criteria applied), corresponding...
Real-world data are used to inform decision-makers and optimise therapeutic management for patients with ulcerative colitis (UC) Crohn's disease (CD). We analysed on the epidemiology (by using proxies of prevalence incidence), patient characteristics, treatment patterns associated healthcare direct costs UC CD in Italy. This retrospective observational study administrative databases from eight Local Health Units geographically distributed across Adult a hospitalisation and/or an exemption or...
Abstract Background This cross-sectional study aimed to identify actionable factors improve LDL-cholesterol target achievement and overcome underuse of lipid-lowering treatments in high- or very-high-cardiovascular risk patients. Methods We evaluated healthcare records 934,332 subjects from North-Italy, including with available lipid profile being on statin up December 2018. A 6-month-period defined adherence proportion-of-days-covered ≥ 80%. Treatment was classified as high-intensity-statin...
Background and Objectives: This analysis described rifaximin utilization in Italian patients with hepatic encephalopathy (HE). Although is effective preventing HE relapses, therapeutic management prescriptive attitudes might be improved. Materials Methods: Between Oct-2020 Sep-2021, approximately 12.7 million citizens, hospitalized for HE, were identified through the ICD-9-CM code 572.2. Among those discharged alive, of 550 mg vs. 200 two months post-admission was compared. Results: Of 634...
Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infection and can lead to severe disease in older adults or those with comorbidities. This analysis aims evaluate the demographic clinical burden RSV hospitalizations among Italy inform potential preventative strategies. Adults aged ≥50 years ≥1 hospitalization discharge diagnosis for from 2010 2021 were included. Demographic characteristics before first outcomes during this 12 months following are described. Of 243...
Background and Objectives: HCV infection represents a main risk factor for type 2 diabetes (T2D). This real-world analysis investigated the HCV-positive (HCV+) population with T2D co-diagnosis in Italy. Methods: From 2017 to 2021, HCV+ patients were identified from administrative databases stratified into T2D-HCV+ HCV+-only cohorts presence/absence of diagnosis. Both further divided by treatment direct-acting antivirals (DAAs). The subgroups compared demographic variables, comorbidity...
Adherence to cardiovascular drug treatment can significantly benefit from a reduced pill burden, but data on this matter derived real-life settings are currently scanty. This analysis assessed the possible changes in adherence patients treated with rosuvastatin and ezetimibe (ROS/EZE) as free multi-pill combination who switched ROS/EZE single-pill setting of real clinical practice Italy. A retrospective was conducted administrative databases for catchment area about seven million...
Objective: The purpose of this study was to assess the changes in adherence treatment, patients who switched from perindopril and/or amlodipine as a monotherapy (single-pill therapy, SPT) or two-pill combinations fixed-dose combination (FDC) therapy.Methods: A large retrospective cohort study, three Italian Local Health Units, performed. All adult subjects received at least one prescription anti-hypertensive drugs between January 1, 2010 and December 31, 2014 were selected. date first...
This real-world analysis evaluated the clinical and economic burden of non-dialysis-dependent CKD patients with without secondary hyperparathyroidism (sHPT) in Italy. An observational retrospective study was conducted using administrative databases containing a pool healthcare entities covering 2.45 million health-assisted individuals. Adult hospitalization discharge diagnoses for stages 3, 4, 5 were included from 1 January 2012 to 31 March 2015 stratified presence/absence sHPT. Of 5710...
A retrospective analysis was conducted to estimate the number of patients with focal epilepsy and drug-resistant (DRE) their characteristics, therapeutic patterns, consumption health resources in a real-world Italian setting.A study carried out on administrative databases sample Health Departments, covering approximately 8.7 million health-assisted individuals. All adult at least one hospitalization for an electroencephalogram (between 01/2010 12/2019), prescription antiseizure medication...
Background: Statins are standard therapies after myocardial infarction (MI) in the general population. In current study, we assessed adherence to statin treatment by patients an MI Italy, and estimated effect of in-hospital therapy on persistence during a 2-year follow-up. Patients methods: This was retrospective cohort observation study who experienced their between January 1, 2004 December 31, 2005. enroll were identified diagnosis at discharge from hospital. Previous drug hospital...
Objectives Investigate the prevalence of obesity in Italy and examine its resource consumption economic impact on Italian national healthcare system (NHS). Design Retrospective, observational real-life study. Setting Data from three health units Northern (Bergamo, Lombardy), Central (Grosseto, Tuscany) Southern (Naples, Campania) Italy. Participants All patients aged ≥18 years with at least one recorded body mass index (BMI) measurement between 1 January 2009 31 December 2012 were included....
Purpose: A retrospective analysis of real-world data was performed to assess the epidemiology and economic burden multiple sclerosis (MS), relapsing-remitting MS (RRMS), secondary-progressive (SPMS) in Italy. Patients Methods: An observational study on administrative databases from a sample Italian entities carried-out. Between 01/2010– 12/2017, patients with ≥ 1 diagnosis code (ICD-9-CM:340 and/or exemption code:046) disease-modifying therapies (DMTs) prescription, were included. Among...
This real-world analysis investigated patients with follicular lymphoma in Italy receiving three or more treatment lines (≥3L), focusing on therapeutic pathways their rebounds healthcare resource consumptions and costs. Data were retrieved from administrative databases entities covering about 13.3 million residents. Adults diagnosed identified between January 2015 June 2020, among them 2434 ≥3L of during the data availability interval (January 2009 to 2021) included. Of them, 1318 3L, 494 4L...