A5021480371- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- Ion Channels and Receptors
- Neuroscience of respiration and sleep
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Infant Health and Development
- Biochemical Analysis and Sensing Techniques
- Voice and Speech Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Heart Rate Variability and Autonomic Control
- Olfactory and Sensory Function Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mast cells and histamine
- Nitric Oxide and Endothelin Effects
- Sarcoidosis and Beryllium Toxicity Research
- Respiratory Support and Mechanisms
- Gastroesophageal reflux and treatments
- Animal Behavior and Welfare Studies
- Effects of Environmental Stressors on Livestock
- Diabetes and associated disorders
- Neuropeptides and Animal Physiology
- Advanced Chemical Sensor Technologies
- Sex and Gender in Healthcare
- Grit, Self-Efficacy, and Motivation
Comenius University Bratislava
2016-2025
Czech Academy of Sciences
2020
Czech Academy of Sciences, Institute of Physiology
2020
Martin University Hospital
2012-2016
University Library in Bratislava
2014
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences
2006
The cold-sensitive cation channel TRPM8 is a target for menthol, which used routinely as cough suppressant and an additive to tobacco food products. Given that cold temperatures menthol activate neurons through gating of TRPM8, it unclear how actively suppresses cough. In this study we describe the antitussive effects (-)-menthol in conscious anesthetized guinea pigs. pigs, evoked by citric acid applied topically tracheal mucosa was suppressed only when selectively administered vapors upper...
Abstract Over the past years, eosinophils have become a focus of scientific interest, especially in context their recently uncovered functions (e.g. antiviral, anti‐inflammatory, regulatory). These versatile cells display both beneficial and detrimental activities under various physiological pathological conditions. Eosinophils are involved pathogenesis many diseases which can be classified into primary (clonal) secondary (reactive) disorders idiopathic (hyper)eosinophilic syndromes....
Cough, the most important airways defensive mechanism is modulated by many afferent inputs either from respiratory tussigenic areas, but also drive other organs. In animal models, modulation of cough nasal can facilitate or inhibit response, depending on type trigeminal afferents stimulated.In this study we addressed question possible bidirectional response in human healthy volunteers challenges with TRPA1 and TRPM8 agonists respectively. After isocyanate (AITC), cinnamaldehyde, (-) menthol...
General idea of this comprehensive review is to summarize information about the role nitric oxide in human body—cardiovascular, respiratory, urgenital, gut, NO and immune system, however, signaling has a also musculoskeletal even bones. past had been recognized as molecule relevant air pollution. In 1980 Furchgott Zawadzki identified new messenger within endothelial cells with vasodilating potential they named it endothelium derived relaxing factor (EDRF). Seven years later was definitely...
Background. Numerous studies show higher cough reflex sensitivity (CRS) and outcomes in children compared to adults females males. Despite close link that exists between environment the potential influence of environmental air pollution on age- gender -related differences has not been studied yet. Purpose. The purpose our study was analyse whether effects exposure tobacco smoke (ETS) from parental smoking PM10 living urban area are implied gender-related healthy, non asthmatic children....
Cough is the commonest respiratory symptom leading to a medical consultation. Although acute cough which usually associated with viral infection not problem manage, chronic frequently diagnostic and therapeutic challenge as it does respond usual treatments. Specific group of coughers are considered have upper airway diseases, lately categorized having syndrome. There an increasing pool evidence that diseases significant involvements in regulation reflex, indicating they must be taken into...
Cough is a common and important symptom of asthma allergic rhinitis. Previous experimental evidence has shown enhanced cough sensitivity during early phase rhinitis in guinea pigs. We hypothesized that airway inflammation the late response after repeated nasal antigen challenge may affect afferent sensory nerve endings larynx tracheobronchial tree also modulate response. In present study we evaluated period sensitized pigs challenges. Forty-five were with ovalbumin (OVA). Four weeks later...