A5049461530- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Cardiac Valve Diseases and Treatments
- Xenotransplantation and immune response
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac and Coronary Surgery Techniques
- Renal Transplantation Outcomes and Treatments
- Cardiac Ischemia and Reperfusion
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Viral Infections and Immunology Research
- Infective Endocarditis Diagnosis and Management
- Tissue Engineering and Regenerative Medicine
- Congenital Heart Disease Studies
- Virus-based gene therapy research
- Electrospun Nanofibers in Biomedical Applications
- Organ and Tissue Transplantation Research
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
- Cardiac Imaging and Diagnostics
- Animal Genetics and Reproduction
- Coronary Interventions and Diagnostics
- Anesthesia and Neurotoxicity Research
- Nitric Oxide and Endothelin Effects
Ludwig-Maximilians-Universität München
2015-2024
Maxim Integrated (Germany)
2024
LMU Klinikum
2009-2023
German Centre for Cardiovascular Research
2019
Bavarian Research Foundation
2017
Centre of Experimental Medicine of the Slovak Academy of Sciences
2014-2015
Institut für Urheber- und Medienrecht
2014
München Klinik
2000-2013
Klinik für Herzchirurgie Karlsruhe
1984-2011
Foundation of Cardiac Surgery Development
2000-2010
Background— The astonishing thickness of the endothelial glycocalyx, which rivals that cells in microvasculature, was disclosed last 15 years. As already demonstrated, this structure plays a key role regulation inflammation and vascular permeability. Methods Results— Two components syndecan-1 heparan sulfate, were measured arterial blood 18 patients undergoing surgery ascending aorta with cardiopulmonary bypass (n=12 n=6 without deep hypothermic circulatory arrest) 14 for infrarenal aortic...
Objective: To compare two thermodilution methods for the determination of cardiac output (CO)-thermodilution in pulmonary artery (COpa) and femoral (COa)-with each other with CO determined by continuous pulse contour analysis (COpc) terms reproducibility, bias, correlation among different methods. Good agreement between would indicate potential to monitor continuously at reduced invasiveness. Design: Prospective criterion standard study. Setting: Cardiac surgical intensive care unit a...
Accelerated graft vessel disease (GVD) represents the most serious long-term complication of heart transplantation. A possible cause underlying this progressive coronary vascular is believed to be post-transplantation hypercholesterolemia.In a 4-year prospective randomized study with transplant recipients, efficacy primary antihypercholesterolemic therapy simvastatin was compared that general dietary therapy. The aim treatment maintain LDL-cholesterol levels at <120 mg/dL. Seventy-two...
The purpose of this randomized study was to compare sirolimus-eluting stenting with coronary artery bypass grafting (CABG) for patients unprotected left main (ULM) disease. CABG is considered the standard care treatment ULM. Improvements in percutaneous intervention (PCI) use drug-eluting stents might lead similar results. effectiveness versus surgery has not been established a trial. In prospective, multicenter, trial, 201 ULM disease were randomly assigned undergo (n = 100) or using...
In Brief Objective The method of determining continuous cardiac output (CO) with beat-to-beat pulse-contour analysis calibrated by transthoracic thermodilution is gaining much wider clinical acceptance. However, some questions have been raised regarding the reliability this during periods profound hemodynamic instability. We validated original calculation and a new, improved algorithm against thermodilution-derived measurements CO in patients changes >20%. Design Comparative study. Setting...
An evaluation of the beneficial effects hormonal therapy, consisting T3 2 micrograms, cortisol 100 mg, and insulin 20 units, administered at hourly intervals intravenously, was assessed in brain-dead patients referred for organ donation. Twenty-six conventionally treated donors (group A) showed a progressive hemodynamic deterioration requiring significant increments inotropic support order to maintain cardiovascular stability, necessitating increase bicarbonate requirements normal acid-base...
Late after cardiac transplantation, limited reinnervation of the transplanted heart may occur, but little is known about effect on function and exercise performance.
Background— Randomized clinical trials have demonstrated that the use of statins in heart transplant patients lowers cholesterol levels and significantly reduces mortality development vasculopathy. The aim present study was to test these effects safety statin therapy over an 8-year period. Methods Results— In 1991, a prospective, randomized, unmasked initiated compare efficacy simvastatin, started on fourth postoperative day (n=35), with dietary alone (n=37). Because improved survival lower...
There is evidence that the failing human left ventricle in vivo subjected to additional preload unable use Frank-Starling mechanism. The present study compared force-tension relation nonfailing and terminally (heart transplants required because of dilated cardiomyopathy) myocardium. Isometric force contraction electrically driven ventricular papillary muscle strips was studied under various conditions (2 20 mN). To investigate influence inotropic stimulation, presence cardiac glycoside...
Monitoring of cardiac preload is mainly performed by measurement central venous and pulmonary capillary wedge pressure in combination with assessment output, applying the arterial thermal dilution technique. However, filling pressures are negatively influenced mechanical ventilation artery catheter criticized because its inherent risks. Measurement right atria, ventricular, global end diastolic intrathoracic blood volume index dye utilizing COLD-system may represent an alternative.In 30 CABG...
Use of wearable left ventricular assist systems (LVAS) in the treatment advanced heart failure has steadily increased since 1993, when these devices became generally available Europe. The aim this study was to identify an unselected cohort LVAS recipients those aspects patient selection that have impact on postimplant survival.Data were obtained from Novacor European Registry. Between 1993 and 1999, 464 patients implanted with LVAS. majority had idiopathic (60%) or ischemic (27%)...
Abstract Xenotransplantation using pig organs has achieved survival times up to 195 days in orthotopic heart transplantation into baboons. Here we demonstrate that addition an improved immunosuppressive regimen, non-ischaemic preservation with continuous perfusion and control of post-transplantation growth the transplant, prevention transmission porcine cytomegalovirus (PCMV) plays important role achieving long times. For first time PCMV xenotransplantation was associated a reduced...
Background —Routine methods for surveillance of cardiac allograft vasculopathy (CAV) are coronary angiography and intravascular ultrasound (IVUS). This study analyzed the diagnostic prognostic value dobutamine stress echocardiography (DSE) noninvasive assessment CAV. Methods Results —In 109 heart transplant recipients, 333 DSEs were compared with 285 angiograms 199 IVUS analyses. Studies repeated after 1, 2, 3, 4, ≥5 years in 88, 74, 37, 18, 7 patients, respectively. Resting 2D detected CAV...