A5041300990- Drug Solubulity and Delivery Systems
- German Literature and Culture Studies
- Acoustic Wave Resonator Technologies
- Astronomy and Astrophysical Research
- Stellar, planetary, and galactic studies
- Plant tissue culture and regeneration
- DNA and Nucleic Acid Chemistry
- Adaptive optics and wavefront sensing
- Crystallization and Solubility Studies
- Protein purification and stability
- Renal Transplantation Outcomes and Treatments
- Advanced Drug Delivery Systems
- Literature and Cultural Memory
- Mechanical and Optical Resonators
- Plant nutrient uptake and metabolism
- Microwave Engineering and Waveguides
- Analytical Chemistry and Chromatography
- Pharmacological Effects and Toxicity Studies
- Chemical Synthesis and Analysis
- Organ Transplantation Techniques and Outcomes
- Astrophysics and Star Formation Studies
- biodegradable polymer synthesis and properties
- Biopolymer Synthesis and Applications
- Analytical Methods in Pharmaceuticals
- Microencapsulation and Drying Processes
University of Bonn
2016-2025
German Center for Infection Research
2020-2024
Rosenheim Technical University of Applied Sciences
2001-2022
Pharmaceutical Biotechnology (Czechia)
2019-2020
Heidelberg University
2012-2019
Max Planck Institute for Astronomy
2006-2019
Institut Kurz
2019
Case Western Reserve University
2015-2018
MetroHealth Medical Center
2015-2018
Boehringer Ingelheim (Germany)
2005-2017
Cyclin-dependent kinase 6 (CDK6) is an important regulator of the cell cycle. Together with CDK4, it phosphorylates and inactivates retinoblastoma (Rb) protein.
Small-molecule heterobifunctional degraders can effectively control protein levels and are useful research tools.
Persistent hyperparathyroidism after renal transplantation (Rtx) has been reported in several studies. However these studies evaluated biochemical bone parameters either only during a short time period (up to 6 months) or for longer period, but with long intervals between. Therefore, we prospectively of kidney-transplant recipients at 2 years surgery.Biochemical were investigated 129 patients 2, 3, 5, 8, 12, 18 and 24 months Rtx. All received prednisone cyclosporin A as immunosuppressive...
In a prospective randomized trial we evaluated the influence of calcium antagonist diltiazem (Dil) on development acute tubular necrosis (ATN) in cadaveric kidney transplantation. Dil was added to Euro-collin's solution (20 mg/l) at donor nephrectomy. The graft recipient received preoperative bolus injection (0.28 mg/kg) which followed by an infusion (0.0022 mg/min/kg) for 2 days. Thereafter, applied orally. Immunosuppressive therapy consisted ciclosporin (CS) and low-dose steroids. There...
Our group developed a protocol, entitled Early Appropriate Care (EAC), to determine timing of definitive fracture fixation based on presence and severity metabolic acidosis. We hypothesized that utilization EAC would result in fewer complications than historical cohort patients with within 36 h have those treated at later time.Three hundred thirty-five mean age 39.2 years Injury Severity Score (ISS) 26.9 380 fractures the femur (n = 173), pelvic ring 71), acetabulum 57), and/or spine 79)...
CARMENES (Calar Alto high-Resolution search for M dwarfs with Exo-earths Near-infrared and optical Echelle Spectrographs) is a next-generation instrument the 3.5m telescope at Calar Observatory, built by consortium of eleven Spanish German institutions. The consists two separate échelle spectrographs covering wavelength range from 0.55 μm to 1.7 spectral resolution R = 82, 000, fed fibers Cassegrain focus telescope. Both are housed in temperature-stabilized vacuum tanks, enable long-term 1...
Few technologies have achieved such worldwide success as mobile communications technology has over the last several decades. Mobile wireless communication is still evolving at a fast pace and continues to create new possibilities for daily application. As demand more energy-efficient faster computing power grows, so does need transmission high data rates, driven by users' eager acceptance of streaming high-definition video other innovations. To cope with bandwidth, frequency bands been...
Biphasic dissolution systems achieved good predictability for the in vivo performance of several formulations poorly water-soluble drugs by characterizing dissolution, precipitation, re-dissolution, and absorption. To achieve a high degree predictive performance, acceptor media, aqueous phase composition, apparatus type have to be carefully selected. Hence, combination 1-decanol an optimized buffer system are proposed as new, one-vessel biphasic method (BiPHa+). The BiPHa+ was developed...
Proteolysis targeting chimeras (PROTACs) hijacking the cereblon (CRBN) E3 ubiquitin ligase have emerged as a novel paradigm in drug development. Herein we found that linker attachment points of CRBN ligands highly affect their aqueous stability and neosubstrate degradation features. This work provides blueprint for assembly future heterodimeric CRBN-based degraders with tailored properties.
PROteolysis TArgeting Chimaeras (PROTACs) offer new opportunities in modern medicine by targeting proteins that are undruggable to classic inhibitors. However, due their hydrophobic structure, PROTACs typically suffer from low solubility, and oral bioavailability remains challenging. At the same time, investigative state, drug supply is meager, leading limited possibilities terms of formulation development. Therefore, we investigated solubility enhancement employing mini-scale formulations...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPeptide conformations. 42. Conformation of side chains in peptides using heteronuclear coupling constants obtained by two-dimensional NMR spectroscopyHorst Kessler, C. Griesinger, and K. WagnerCite this: J. Am. Chem. Soc. 1987, 109, 23, 6927–6933Publication Date (Print):November 1, 1987Publication History Published online1 May 2002Published inissue 1 November...
CARMENES (Calar Alto high-Resolution search for M dwarfs with Exo-earths Near-infrared and optical Echelle Spectrographs) is a next-generation instrument to be built the 3.5m telescope at Calar Observatory by consortium of Spanish German institutions. Conducting five-year exoplanet survey targeting ~ 300 stars completed an integral part project. The consists two separate spectrographs covering wavelength range from 0.52 1.7 μm spectral resolution R = 85, 000, fed fibers Cassegrain focus...