A5103149872- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Multiple Myeloma Research and Treatments
- Mast cells and histamine
- Chemokine receptors and signaling
- CAR-T cell therapy research
- Sarcoma Diagnosis and Treatment
- Immune cells in cancer
- Hematological disorders and diagnostics
- Platelet Disorders and Treatments
- Drug Transport and Resistance Mechanisms
- Metal complexes synthesis and properties
- Porphyrin Metabolism and Disorders
- Pluripotent Stem Cells Research
- Periodontal Regeneration and Treatments
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- Immunotherapy and Immune Responses
- Genomic variations and chromosomal abnormalities
Skaraborg Hospital
2012-2024
Karolinska Institutet
2009-2019
Karolinska University Hospital
2009-2018
Center for Cancer Research
2010
Philipps University of Marburg
2007-2010
Georgetown University Medical Center
2010
Georgetown University
2010
National Institutes of Health
2010
National Cancer Institute
2010
International Society for Experimental Hematology
2009
Although the development of tyrosine kinase inhibitors (TKIs) to control unregulated activity BCR-ABL revolutionized therapy chronic myeloid leukemia, resistance TKIs is a clinical reality. Among postulated mechanisms overexpression ATP-binding cassette (ABC) transporters, such as P-glycoprotein (ABCB1) and breast cancer protein (ABCG2), which mediate reduced intracellular drug accumulation. We compared interactions imatinib, nilotinib, dasatinib with ABCB1 ABCG2 in ex vivo vitro systems....
A high proportion of patients with lower-risk del(5q) myelodysplastic syndromes will respond to treatment lenalidomide. The median duration transfusion-independence is 2 years some long-lasting responses, but almost 40% progress acute leukemia by 5 after starting treatment. mechanisms underlying disease progression other than the well-established finding small TP53-mutated subclones at diagnosis remain unclear. We studied a longitudinal cohort 35 low- and intermediate-1-risk treated...
Transplanted hematopoietic cells have previously been shown to contribute of other tissues by cell fusion. We wanted elucidate whether this phenomenon fusion also occurs under physiological conditions. Using a transgenic mouse reporter system irreversibly label the lineage, we were able test their contribution in absence any additional and potentially confounding factors such as irradiation or chemoablation. found genetically marked, fused Purkinje neurons well hepatocytes numbers comparable...
Summary The mechanisms underlying lenalidomide‐resistance of del(5q) MDS stem cells remain to be elucidated and may include cell‐intrinsic as well microenvironmental causes. Abnormal hypolobated megakaryocytes constitute one the hallmarks . We hypothesized that these have potential implications for regulation haematopoietic ( HSC ) similarly what has recently been described in murine system. Therefore, we conducted a study determine response abnormal lenalidomide therapy. studied...