A5016789272- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmacovigilance and Adverse Drug Reactions
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Antifungal resistance and susceptibility
- Cancer, Lipids, and Metabolism
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Cardiac electrophysiology and arrhythmias
- Oral health in cancer treatment
- Medical and Health Sciences Research
- Liver Disease Diagnosis and Treatment
- Healthcare Systems and Technology
- Bladder and Urothelial Cancer Treatments
- Antibiotic Use and Resistance
- Medication Adherence and Compliance
- Cholesterol and Lipid Metabolism
- Complementary and Alternative Medicine Studies
- Patient Safety and Medication Errors
- Pharmacological Effects and Toxicity Studies
- Head and Neck Cancer Studies
- Meta-analysis and systematic reviews
- Renal function and acid-base balance
Ludwig-Maximilians-Universität München
2015-2025
LMU Klinikum
2015-2025
Jena University Hospital
2024
München Klinik
2013-2023
Postoperative delirium (POD) is the most common complication following surgery in elderly patients. During pharmacist-led medication reconciliation (PhMR), a predictive risk score considering risk-increasing drugs and other available factors could help to identify
Background/Objectives: QTc prolongation can result in lethal arrhythmia. Risk scores like the Tisdale score be used for risk stratification targeted pharmaceutical interventions. However, practical usability across different medical specialties has not been sufficiently investigated. The aim of this study was to compare relevant factors and investigate use cardiology gastroenterology patients. Methods: For patients on a ward receiving weekly electronic chart review, prolongation,...
Medication reviews (MR) are essential for optimizing patient care and drug therapy safety. This study examined clinical pharmacists' decision-making during MRs. Five pharmacists from university hospitals in Germany conducted intermediate MRs utilizing the think-aloud method, which were transcribed modeled as knowledge graphs representing their processes. Our findings revealed variability decision paths problem identification, despite often reaching similar conclusions. The use of provided...
Invasive fungal infections in haematological and oncological patients have a major impact on morbidity, mortality treatment costs. Therefore, rational use of antifungal agents is important for optimal patient care resource use. The study's objective was to analyse usage German tertiary teaching hospital, department haematology oncology, evaluate quality assess the need an stewardship programme. This retrospective observational study included ≥18 years receiving systemic antifungals...
Two to seven percent of the German adult population has a renal impairment (RI) with an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m2. This often remains unrecognized and adjustment drug therapy is lacking. To determine function in clinical routine, CKD-EPI equation used calculate indexed eGFR (ml/min/1.73m2). For dosing, it be individualized non-indexed (ml/min) by patient's body surface area. Here, we investigated number patients admitted urological wards teaching hospital...
Medication analyses by ward pharmacists are an important measure of drug therapy safety (DTS). Medication-related problems (MRPs) identified and resolved with the attending clinicians. However, staff resources for extended medication complete documentation often limited. Until now, data required identification risk patients analysis had to be collected from various parts institution's internal electronic medical record (EMR). This error-prone time-consuming process is improved in INTERPOLAR...
Abstract Objectives Adverse drug reactions (ADRs) are a major safety concern and frequent topic of enquiries to hospital information services. Our goal was analyse these regarding background, complexity, nature ADR, involved classes improve in-hospital safety. Methods Retrospectively, ADR German university pharmacy 2018–2022 were analysed enquirer (profession, medical specialty) enquiry details (drugs, suspected ADR/enquiry prior initiation, system organ class, probable cause identified,...
Abstract Background QTc interval prolongation can result in potentially lethal arrhythmias. One risk factor is QTc-prolonging drugs, including some antifungals often used hemato-oncology patients. Screening tools for patients at have not yet been investigated this patient population. Aim Our aim was to evaluate the sensitivity and specificity of five scores receiving systemic antifungal therapy. Method Data were retrieved from an internal study database adult prescribed on medication,...
Postoperative delirium (POD) is a common complication in older adult patients after surgery. A patient's preoperative anticholinergic (AC) burden potentially modifiable risk factor for POD. As the influence of drug dose remains unknown, we aimed to compare three AC scores relation POD, two which were dose-related. This retrospective cohort study (03/22–10/22) included orthopaedic and trauma surgery > 65 years. POD was assessed using four A's test (4AT), diagnosis, chart review. The...
<h3>Objectives</h3> Data on the clinical impact of a drug information service (DIS) patient care are still insufficient. By analysing actions following DIS response to enquiries, we studied decision making, specifically concerning drug–drug interactions (DDI). <h3>Methods</h3> A prospective study, November 2008 December 2009, identified physicians' enquiries DDIs university hospital pharmacy DIS. Written was analysed for reason enquiry, number and severity DDI recommended actions. Enquirers...
A 'renal pharmacist consultant service' (RPCS) reviewing patients' charts with renal impairment (RI) for drug-related problems (DRP) can foster patient safety. However, the benefit of this service in new setting a computerized physician order entry (CPOE)-system clinical decision support (CDS)-system is unknown. The aim our study was to evaluate general need an RPCS on wards CPOE-CDS-system already use and its effectiveness prescription changes ensure in-hospital safety.Over period 3 months...
Renal impairment (RI) and renal drug-related problems (rDRP) often remain unrecognized in the community setting. A "renal pharmacist consultant service" (RPCS) at hospital admission can support patient safety by detecting rDRP. However, efficient information sharing from pharmacists to physicians is still discussed. The aim of study was test implementation a RPCS its effectiveness on prescription changes evaluate two ways written with physicians.Urological patients eGFRnon-indexed 15-59...
Background Chronic drug therapy may impact recurrence and survival of patients with bladder cancer thus be concern regarding choice treatment decisions. Currently, data are conflicting for some classes missing others. Objective To analyze the common non-oncologic chronic intake on in radical cystectomy. Setting. Patients cystectomy (2004-2018) at University Hospital Munich. Method Data from an established internal database were included a retrospective study. Drug time assessed follow-up...
Abstract Purpose Male infertility is a multifactorial state. Among other risk factors, drugs can adversely affect male fertility and sexual function. In retrospective study we aimed to analyse how many involuntarily childless men seeking evaluation consume drugs, which if these are potentially affecting reproductive Methods We retrospectively identified presenting for at an andrologic outpatient department from 2011 2014. Medical records were searched current drug use, age, diseases...
Hepatic impairment (HI) is a known risk factor for drug safety. The MELD score (Model-for-endstage-liver-disease), calculated from serum creatinine, bilirubin and International Normalized Ratio (INR), promising screening tool corresponding to Child-Pugh Score (CPS) adjustment. We tested the feasibility of as an automatic accounting correct calculation, interfering factors (IF) detection patients CPS-B/C potentially requiring adjustment.We retrospectively 3-month cohort surgical assessed need...
Hepatic impairment (HI) influences the pharmacokinetics and pharmacodynamics of drugs represents an important risk factor for drug safety. A reliable screening tool HI identification at hospital admission by pharmacists would be desirable but is currently lacking. Therefore, we tested four liver scores as potential instruments. We retrospectively recorded liver/bile diagnoses, symptoms abnormalities (summarized hepatic findings) 200 surgical patients followed assessment relevance these...
<h3>Objectives</h3> Guidelines for drug information (DI) provided by hospital pharmacists call quality assurance procedures; however, no method of evaluation is internationally agreed on. The procedure should be feasible, reproducible and representative real-life quality. We tested a new approach using fictitious enquiry under simulated conditions assessment DI German pharmacists. <h3>Methods</h3> A was submitted (study part I; test week announced, but not exact day; response time given). An...