A5037902749- RNA and protein synthesis mechanisms
- Microbial Natural Products and Biosynthesis
- Chemical Synthesis and Analysis
- Chemical synthesis and alkaloids
- Eating Disorders and Behaviors
- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- Pesticide and Herbicide Environmental Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Mindfulness and Compassion Interventions
- Diet and metabolism studies
- Effects and risks of endocrine disrupting chemicals
- Marine Sponges and Natural Products
Goethe University Frankfurt
2022-2024
LOEWE Centre for Translational Biodiversity Genomics
2022-2024
ETH Zurich
2020
Chulabhorn Graduate Institute
2020
Bacterial specialized metabolites are increasingly recognized as important factors in animal–microbiome interactions: for example, by providing the host with chemical defenses. Even chemically rich animals, such compounds have been found to originate from individual members of more diverse microbiomes. Here, we identified a remarkable case moderately complex microbiome sponge Mycale hentscheli which multiple symbionts jointly generate diversity. In addition bacterial pathways three distinct...
Abstract Biomacromolecules are known to feature complex three‐dimensional shapes that essential for their function. Among natural products, ambiguous molecular a rare phenomenon. The hexapeptide tryptorubin A can adopt one of two unusual atropisomeric configurations. Initially hypothesized be non‐ribosomal peptide, we show is the first characterized member new family ribosomally synthesized and posttranslationally modified peptides (RiPPs) named atropopeptides. sole modifying enzyme encoded...
A machine learning-based algorithm was developed to map the biosynthetic space of a peptide family characterized by intricate 3D shapes, and facilitated characterization complex peptides with varying length, complexity types modifications.
Abstract Ribosomally synthesized and posttranslationally modified peptides (RiPPs) constitute a diverse class of natural products. Atropopeptides are recent addition to the fast-growing number RiPP families. Characterized members peptide family feature particular intricate three-dimensional shape. Here we developed AtropoFinder, machine learning-based algorithm chart biosynthetic landscape atropopeptides. AtropoFinder identified more than 650 atropopeptide gene clusters (BGCs). Through...
Abstract Biomacromolecules are known to feature complex three‐dimensional shapes that essential for their function. Among natural products, ambiguous molecular a rare phenomenon. The hexapeptide tryptorubin A can adopt one of two unusual atropisomeric configurations. Initially hypothesized be non‐ribosomal peptide, we show is the first characterized member new family ribosomally synthesized and posttranslationally modified peptides (RiPPs) named atropopeptides. sole modifying enzyme encoded...