A5001525301- Microbial Natural Products and Biosynthesis
- Natural product bioactivities and synthesis
- Bioactive Compounds and Antitumor Agents
- RNA and protein synthesis mechanisms
- Plant biochemistry and biosynthesis
- melanin and skin pigmentation
- Garlic and Onion Studies
- Phytochemistry and Biological Activities
- Bioactive natural compounds
- Chemical Synthesis and Analysis
- Plant Gene Expression Analysis
- Oxidative Organic Chemistry Reactions
- Skin Protection and Aging
- Synthesis of Organic Compounds
- Microbial Metabolism and Applications
- Axial and Atropisomeric Chirality Synthesis
- RNA modifications and cancer
- Natural Compound Pharmacology Studies
- Nephrotoxicity and Medicinal Plants
- Microbial Metabolic Engineering and Bioproduction
- Carbohydrate Chemistry and Synthesis
- Contact Dermatitis and Allergies
- Morinda citrifolia extract uses
- Phytochemicals and Antioxidant Activities
- Metabolomics and Mass Spectrometry Studies
Goethe University Frankfurt
2023-2025
LOEWE Centre for Translational Biodiversity Genomics
2023-2025
Gifu University
2019-2024
Takasago (Japan)
2020-2024
Many complex terpenoids, predominantly isolated from plants and fungi, show drug-like physicochemical properties. Recent advances in genome mining revealed actinobacteria as an almost untouched treasure trove of terpene biosynthetic gene clusters (BGCs). In this study, we characterized a BGC with unusual architecture. The selected includes, among others, genes encoding cyclase fused to truncated reductase domain cytochrome P450 monooxygenase (P450) that is split over three fragments....
Abstract Diallyl disulfide (DADS) and allyl methyl sulfide (AMS) have been known as a metabolic product of sulfur-containing foods, typically garlic. The odour such organosulfur compounds following garlic ingestion is often considered an unpleasant element. Although previous studies identified the DADS AMS associated with breath, no study has reported on determination both emanating from human skin surface. This aimed to demonstrate effect dermal emissions using passive flux sampler coupled...
A machine learning-based algorithm was developed to map the biosynthetic space of a peptide family characterized by intricate 3D shapes, and facilitated characterization complex peptides with varying length, complexity types modifications.
In this study, three new garcinoic acid dimers, δ,δ-bigarcinoic (1), δ,δ-bi-O-garcinoic (2), and γ,δ-bi-O-garcinoic (3), a benzophenone derivative, (8E)-4-geranyl-3,5-dihydroxybenzophenone (4), as well seven known compounds (5–11) were isolated from the seeds of Garcinia kola. The structures elucidated using MALDI-TOF-MS spectroscopic data, including 1D 2D NMR electronic circular dichroism spectra. All evaluated for their antimicrobial activity against two oral pathogens, Porphyromonas...
The roots of Fibraurea recisa are recognized as a rich source protoberberine and aporphine alkaloids, but the non-alkaloidal metabolites in this plant underexplored. present study investigated chemical composition using untargeted metabolomics-based molecular networking MS2LDA motif annotation, revealing presence characteristic fragment related to several sinapoyl-functionalized metabolites. Guided by targeted motif, two new sinapic acid-ecdysteroid hybrids, named 3-O-sinapoyl makisterone A...
Procyanidins, found widely in foods and beverages, are prone to oxidation, yet the chemical structures of their oxidation products mechanisms involved remain unclear. Herein, we report that conformation procyanidin B4 influences its stereochemistry. Eight spirocyclized were obtained from classified as S- or R-forms based on configuration spiro carbons. The ratios derived compact extended rotamers B4, respectively, varied with solvent. DFT calculations suggested four lowest-energy conformers...
Abstract Most of the wood bark produced by forestry production is discarded in spite containing many kinds phytochemical ingredients. The aim present study was to identify secondary metabolites from Larix kaempferi generated as waste material and evaluate their potential cosmetic agents. Eighteen compounds, including a novel phenanthrene, 4,6,7-trihydroxyphenanthrene-2- O - β -D-glucopyranoside ( 16 ), were isolated L. identified matrix assisted laser desorption ionization-time flight mass...
A new benzoic acid, 3-[2-(2-hydroxyphenyl)acetoxy]benzoic acid (1), and two caffeoyl derivatives, methyl (3E,5Z)-di-O-caffeoylquinate (2) dhurrin 6'-O-caffeate (3), along with 20 known compounds were isolated from the leaves of Ilex kaushue collected in Vietnam. Their structures elucidated on basis 1 D 2 NMR spectroscopy, high-resolution MS spectrometry. The absolute configuration 3 was unambiguously established by comparison experimental calculated ECD spectra and/or chemical reactivity. In...
Abstract Ribosomally synthesized and posttranslationally modified peptides (RiPPs) constitute a diverse class of natural products. Atropopeptides are recent addition to the fast-growing number RiPP families. Characterized members peptide family feature particular intricate three-dimensional shape. Here we developed AtropoFinder, machine learning-based algorithm chart biosynthetic landscape atropopeptides. AtropoFinder identified more than 650 atropopeptide gene clusters (BGCs). Through...
An important factor in the aging of face is a reduction volume adipose tissue. This tissue contributes to decreased skin elasticity, which also part process. Overall, these lead wrinkle formation. Fat injection common means addressing this issue and used reduce effects on increase fullness lips breasts. However, fat an invasive surgical procedure. study aimed discover novel cosmetic ingredients that subcutaneous (pre)adipocytes create appearance more youthful skin.We focused number...
Garlic consumption is a well-known cause of unpleasant breath and body odour, with volatile organosulfur compounds, such as diallyl disulfide (DADS) allyl methyl sulfide (AMS) responsible for the characteristic odour. Certain foods that are rich in polyphenols (PPs) polyphenol oxidase (PPO) known to deodorise garlic breath. However, no study into odour has been reported owing very low amounts emitted compounds. Herein, we aimed demonstrate effects ingesting natural food additives both PPs...
近年,有用天然物を獲得するために行われてきた"ものとり研究"が生物活性を指標とした伝統的手法からゲノミクスやメタボロミクスを取り入れた合理的かつ効率的な手法に変化しつつある.中でもタンデム質量分析を基盤としたメタボロミクスは,バイオインフォマティクス解析技術の飛躍的な進歩によって既知物質の迅速同定や代謝物の生体変換の追跡を可能としている.本稿では,タンデム質量分析の膨大なデータからケミカルスペースをネットワークとして可視化できる分子ネットワーク解析とそれを活用した新規化合物の探索,および生物間相互作用に関連する鍵物質同定への取り組みについて解説する.