A5053790926- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Pharmacological Effects and Toxicity Studies
- Stress Responses and Cortisol
- Electroconvulsive Therapy Studies
- Cannabis and Cannabinoid Research
- Cancer Treatment and Pharmacology
- Pharmaceutical studies and practices
- Neurotransmitter Receptor Influence on Behavior
- Neurological and metabolic disorders
- Schizophrenia research and treatment
- Attention Deficit Hyperactivity Disorder
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Epilepsy research and treatment
- Receptor Mechanisms and Signaling
- Treatment of Major Depression
- Neuroendocrine regulation and behavior
- Parkinson's Disease and Spinal Disorders
- Psychosomatic Disorders and Their Treatments
- Sleep and Wakefulness Research
- Mental Health and Psychiatry
- Alcohol Consumption and Health Effects
- Drug-Induced Ocular Toxicity
- Pharmacological Receptor Mechanisms and Effects
Universidade Federal de Santa Catarina
2016-2025
Universidade Federal de Mato Grosso do Sul
2024
Universidade de São Paulo
2005-2006
Fundação de Amparo à Pesquisa do Estado de São Paulo
2006
Universidade de Ribeirão Preto
2005
Consolidation and reconsolidation are phases of memory stabilization that diverge slightly. Noradrenaline is known to influence both processes, but the relative contribution α1- β-adrenoceptors unclear. The present study sought investigate this matter by comparing their recruitment consolidate and/or reconsolidate a contextual fear trace under enhanced noradrenergic activity induced yohimbine. We report α2-adrenoceptor antagonist was able potentiate consolidation or when administered...
Background:Traumatic memories have been resilient to therapeutic approaches targeting their permanent attenuation. One of the potentially promising pharmacological strategies under investigation is search for safe reconsolidation blockers. However, preclinical studies focusing on this matter scarcely addressed abnormal aversive and related outcomes.
Abstract Background and Purpose Ayahuasca (AYA) is a botanical psychedelic with promising results in observational small clinical trials for depression, trauma drug use disorders. Its psychoactive effects primarily stem from N , ‐dimethyltryptamine (DMT). However, there lack of research on how where AYA acts the brain. This study addressed these questions by examining extinction aversive memories AYA‐treated rats. Experimental Approach We focused 5‐HT 1A 2A receptors, as DMT exhibits high...
Abstract The thalamic nucleus reuniens (NR) has been shown to support bidirectional medial prefrontal cortex‐hippocampus communication and synchronization relevant for cognitive processing. Using non‐selective or prolonged inactivation of the NR, previous studies reported its activity positively modulates aversive memory consolidation. Here we examined NR's role in consolidating contextual fear memories with varied strength, at both recent more remote time points, using muscimol‐induced...
Anxiety and trauma-related disorders are psychiatric diseases with a lifetime prevalence of up to 25%. Phobias post-traumatic stress disorder (PTSD) characterized by abnormal persistent memories fear-related contexts cues. The effects psychological treatments such as exposure therapy often only temporary medications can be ineffective have adverse side effects. Growing evidence from human animal studies indicates that cannabidiol, the main non-psychotomimetic phytocannabinoid present in...
The prelimbic cortex has been implicated in the consolidation of previously learned fear. Herein, we report that temporarily inactivating this medial prefrontal subregion with GABA A agonist muscimol (4.0 nmol 0.2 μL per hemisphere) was able to equally disrupt 1-, 7-, and 21-d-old contextual fear memories after their brief retrieval rats. In all cases, effect prevented when memory reactivation omitted. These results indicate recent remote are susceptible reconsolidation blockade induced by...
Abstract Lesioning or inactivating the infralimbic (IL) subregion of medial prefrontal cortex before acquisition produces more generalized and extinction-resistant fear memories. However, whether how it modulates memory specificity extinction susceptibility while consolidation takes place is still unknown. The present study aims to investigate these questions using muscimol-induced temporary inactivation anisomycin-induced protein synthesis inhibition in rat IL following contextual...
The neurochemical mechanisms supporting the role of ventral hippocampus in anxiety are now under investigation. To address this issue, we examined whether pharmacological blockade transient receptor potential vanilloid type 1 (TRPV1) channels would attenuate anxiety-related behaviour. Rats infused with TRPV1 channel antagonist capsazepine (2.0 nmol) showed less inhibitory avoidance than controls elevated plus-maze test. This result indicates an anxiolytic-like effect, and suggests a for...