A5064426203- Ocular Diseases and Behçet’s Syndrome
- Immune cells in cancer
- Cardiac Fibrosis and Remodeling
- Thermoregulation and physiological responses
- Phagocytosis and Immune Regulation
- RNA Research and Splicing
- Cardiovascular Disease and Adiposity
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Skin and Cellular Biology Research
- Helminth infection and control
- Advanced Proteomics Techniques and Applications
- Autoimmune Bullous Skin Diseases
- Autoimmune and Inflammatory Disorders Research
- Single-cell and spatial transcriptomics
- Cell death mechanisms and regulation
- Thermal Regulation in Medicine
- Advanced Biosensing Techniques and Applications
- Glycogen Storage Diseases and Myoclonus
- High Altitude and Hypoxia
- Cancer-related molecular mechanisms research
- Allergic Rhinitis and Sensitization
- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Climate Change and Health Impacts
- Signaling Pathways in Disease
Maastricht University
2019-2022
Centre Hospitalier Saint-Joseph Saint-Luc
2010
Long noncoding RNAs (lncRNAs) are an emergent class of molecules with diverse functional roles, widely expressed in human physiology and disease. Although some lncRNAs have been identified cardiovascular disease, their potential as novel targets the prevention atherosclerosis is unknown. We set out to discover important unstable plaque gain insight into relevance. Approach Results: Analysis RNA sequencing previously performed on stable atherosclerotic a panel 47 differentially regulated...
Acute myocardial infarction (AMI) is accompanied by a systemic trauma response that impacts the whole body, including blood. This study addresses whether macrophages, key players in repair, sense and respond to these changes. For this, healthy human monocyte-derived macrophages are exposed 20% AMI (n = 50) or control 20) serum analyzed transcriptional multiparameter functional screening followed network-guided data interpretation drug repurposing. Results validated an independent cohort at...
Abstract The anti-apoptotic protein myeloid cell leukemia 1 (Mcl-1) plays an important role in survival and differentiation of leukocytes, more specifically neutrophils. Here, we investigated the impact Mcl-1 deletion atherosclerosis. Western type diet fed LDL receptor-deficient mice were transplanted with either wild-type (WT) or LysMCre fl/fl (Mcl-1 −/− ) bone marrow. resulted enhanced apoptosis lipid accumulation atherosclerotic plaques. In vitro , deficient macrophages also showed...