A5081668212- Cancer Treatment and Pharmacology
- Computational Drug Discovery Methods
- HER2/EGFR in Cancer Research
- Plant-based Medicinal Research
- Acute Ischemic Stroke Management
- Inflammatory Myopathies and Dermatomyositis
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Cell Image Analysis Techniques
- Immunodeficiency and Autoimmune Disorders
- Myasthenia Gravis and Thymoma
- Alzheimer's disease research and treatments
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Cerebral Venous Sinus Thrombosis
- Cardiac Arrest and Resuscitation
- Vascular Malformations Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Neurosurgical Procedures and Complications
- Tryptophan and brain disorders
- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
China Pharmaceutical University
2023-2024
State Key Laboratory of Natural Medicine
2023-2024
National Cheng Kung University Hospital
2015-2024
Peking University
2024
Peking University Third Hospital
2024
Qilu Hospital of Shandong University
2018-2022
Shanxi Normal University
2022
Shandong University
2022
McMaster University
2022
First Affiliated Hospital of Kunming Medical University
2022
Inflammatory mediators are closely associated with the pathogenesis of neurodegenerative changes in Alzheimer's disease (AD) and mild cognitive impairment (MCI). Osteopontin (OPN) is a proinflammatory cytokine that has been shown to play an important role various neuroinflammatory diseases. However, function OPN AD MCI progression not well defined. Cerebrospinal fluid (CSF) plasma samples were obtained from 35 patients, 31 20 other noninflammatory neurologic diseases (OND). Concentrations...
Abstract Alzheimer's disease (AD) is a pressing concern in neurodegenerative research. To address the challenges AD drug development, especially those targeting Aβ, this study uses deep learning and pharmacological approach to elucidate potential of pyrroloquinoline quinone (PQQ) as neuroprotective agent for AD. Using comprehensive molecular dataset, blood–brain barrier (BBB) permeability predicted anti‐inflammatory antioxidative properties compounds are evaluated. PQQ, identified...
To evaluate the efficacy of tirofiban administered at different time points within 24 hours intravenous thrombolysis with alteplase in acute ischemic stroke.Patients who underwent and fulfilled other inclusion criteria were randomly divided into 4 groups according to administration: Group A (2 h), B (2-12 C (12-24 D (control). The changes National Institutes Health Stroke Scale score, modified Rankin adverse events analyzed.At 7 ± 1 day, was better than that (P = .006) .001), but there no...
Background Middle meningeal artery embolization (MMAE) for chronic subdural hematoma (CSDH) has gained much attention in recent years. However, unintended may occur when employing liquid embolic agents or particles. We present our clinical experience simple coiling of MMAE to manage CSDH. Methods Patients underwent either surgical evacuation with CSDH were reviewed. Clinical and radiographic outcomes assessed at admission, 1-month, 6-month intervals. Two treatment groups matched inverse...
Anti-mitochondrial antibodies, the hallmark of primary biliary cirrhosis, have been detected in many patients with idiopathic inflammatory myopathies and these anti-mitochondrial-antibody-associated frequently show unique characteristics. We anti-mitochondrial antibodies Chinese myopathy summarized clinical findings anti-mitochondrial-antibody-positive patients. Of 136 patients, seven (5.15%) were found to be anti-mitochondrial-antibody-positive. Primary cirrhosis was present 2 7 chronic...
Alzheimer's disease (AD), an age-related degenerative disorder, is characterized by β-amyloid deposition, abnormal phosphorylation of tau proteins, synaptic dysfunction, neuroinflammation, and oxidative stress. Despite extensive research, there are no medications or therapeutic interventions to completely treat reverse AD. Herein, we explore the potential hydrocortisone (HC), a natural endogenous glucocorticoid known have potent anti-inflammatory properties, in Aβ1-42-induced AD mouse model....
This paper presents the evident effects of acupoint stimulation, using EEG (electroencephalogram) measurements. With acupuncture stimulation and measurement on same meridian, is able to accurately detect acupunctural point brain waves. In this study, 24 subjects without heart or neural diseases were randomly separated into two groups 12, named test control groups. Similar procedures are performed; lay a bed with eyes closed for ten minutes as baseline. The group received at their Waiguan...
Chemotherapy-induced neurotoxicity is a common adverse effect of cancer treatment. No medication has been shown to be effective in the prevention or treatment chemotherapy-induced neurotoxicity. This study aimed discover potential neuroprotective drugs for paclitaxel-induced An image-based high-content platform was first developed screen drugs. The screening system comprised automated image acquisition and multiparameter analysis, including neuronal viability, neurite outgrowth,...
Background and Purpose- The observation that smokers with stroke could have better outcome than nonsmokers led to the term "smoking paradox." controversy of such a complex claim has not been fully settled, even though different case mix was noted. Analyses were conducted on 2 independent data sets evaluate determine whether paradox truly exists. Methods- Taiwan Stroke Registry 88 925 cases, MJ cohort 541 047 adults participating in medical screening program 1630 deaths developed during 15...
Neutrophilic phagocytosis is an essential component of innate immunity. During phagocytosis, the generation bactericidal hypochlorous acid(HOCl) requires substrates, Cl− and superoxide produced by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase to kill internalized pathogens. Here we show that neutrophilic K+–Cl− cotransporter (KCC) constitutes aCl− permeation pathway mediates activity regulating NADPH activation. Dihydroindenyloxy alkanoic acid (DIOA), a KCC inhibitor,...
Background: Stroke is a major cause of disability in the elderly and considerably increases risk dementia, which another important source disability. This population-based study aimed to examine dementia patients with stroke compared non-stroke cases similar comorbidities. Methods: Using Taiwan National Health Insurance databank covering period 2001-2007, this retrospective cohort evaluated 10,884 first who had no history dementia. In study, we performed 1:5 case-control matched analysis,...
Alzheimer’s disease (AD) is a progressive neurodegenerative and linked to abnormal deposition of amyloid-β (Aβ), neurofibrillary tangles (NFTs), synaptic dysfunction, neuroinflammation. Despite significant progress in unravelling the pathogenesis AD, currently main therapeutic interventions limited symptomatic alleviation. Methylprednisolone (MP), synthetic glucocorticoid, recognized for its extensive anti-inflammatory properties. Our study assessed neuroprotective effect MP (25 mg/kg)...
Muscle biopsy is a fundamental procedure to assist the final diagnosis of myopathy. With recent advances in molecular diagnosis, serology tests, and mechanism-based classification myopathy, précised for myopathy required applications multiple tools. This study intends reappraise benefit muscle adult-onset under setting an optimized protocol comprehensive tests. A one-group pretest-posttest design was used. The pre- post-biopsy diagnoses treatments 69 adult patients were compared. yielded...
Sporadic late-onset nemaline myopathy (SLONM) is a treatable or otherwise fatal myopathy. Diagnosis of SLONM still challenging, and no therapeutic consensus has been achieved. Here, we reported the clinicopathologic features long-term follow-up data in Chinese cohort.We performed retrospective evaluation clinical, pathologic, treatment outcomes 17 patients with diagnosed between March 1986 April 2021 at our neuromuscular center. Immunohistochemistry (IHC) antibodies against 5...
Abstract Nerve conduction requires the fine tuning of ionic currents through delicate interactions between axons and Schwann cells. The K + –Cl − cotransporter (KCC) family includes four isoforms (KCC1–4) that play an important role in maintenance cellular osmotic homeostasis via coupled electroneutral movement Cl with concurrent water flux. Mutation SLC12A6 gene encoding KCC3 results autosomal recessive disease, known as agenesis corpus callosum associated peripheral neuropathy....
Intravenous tissue plasminogen activator (tPA) treatment is recommended in acute stroke within 3 h of onset; however, the benefit its use elderly remains uncertain. We assessed safety and efficacy tPA patients.We recruited 97 Chinese patients aged ≥80 years with cerebral ischemia presenting onset. Favorable outcomes were defined as discharge to home modified Rankin Scale (mRS) ≤2 at discharge.For moderate severe (NIHSS ≥6), baseline characteristics between (n = 30) non-tPA 41) group not...
The mutual exclusivity of myositis-specific antibodies (MSAs) has been reported before, but the coexistence 2 or more MSAs was still found in a few case reports. This study aims to confirm existence and prevalence double patients with idiopathic inflammatory myopathy (IIM) clarify clinical features these patients. One hundred fifty-one IIM diagnosed from 1 July 2018 31 2022, at National Cheng Kung University Hospital, Taiwan, were enrolled divided into two groups, ≤1 MSA (n = 128, 84.8%)...
B-cell CLL/lymphoma 11B (Bcl11b) – a C2H2 zinc finger transcriptional factor is known to regulate neuronal differentiation and function in the development of central nervous system (CNS). Although its expression reduced during oligodendrocyte (OLG) differentiation, biological role OLGs remains unknown. In this study, we found that downregulation Bcl11b gene glial progenitor cells (GPCs) by lentivirus-mediated knockdown (KD) causes reduction cell proliferation with inhibited stemness-related...
Aims Diabetes-related cerebral microangiopathy can manifest as small vessel disease (CSVD) and exhibit cognitive decline. To find the early change of function in advance, this study examined spatiotemporal dynamics vascular permeability ( Ktrans ) progression type 2 diabetes mellitus (T2DM). Methods was cross-sectionally measured T2DM non-diabetes groups with or without CSVD using dynamic contrast-enhanced MRI (DCE-MRI). Results In all patients T2DM, white matter (WM) increased, whereas gray...
There are no effective therapeutic targets or strategies that simultaneously inhibit tumour growth and promote cardiac function recovery. Here, we analyzed for cancer treatments repair, with demethylation emerging as a common factor in these candidate lists. As DNA methyltransferase 1 (DNMT1) majorly responds to methylation, natural compound library is screened, identifying dioscin novel agent targeted at DNMT1, widely used heart diseases. Dioscin was found reduce DNMT activities inhibits...