A5006688209- Advanced biosensing and bioanalysis techniques
- MXene and MAX Phase Materials
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- 2D Materials and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Mass Spectrometry Techniques and Applications
- Advanced Chemical Sensor Technologies
- Molecular Biology Techniques and Applications
- Anodic Oxide Films and Nanostructures
- Nanoparticle-Based Drug Delivery
- Electrochemical sensors and biosensors
- Nanocluster Synthesis and Applications
- Metabolomics and Mass Spectrometry Studies
- Advanced Nanomaterials in Catalysis
- Galectins and Cancer Biology
- Electrochemical Analysis and Applications
- Nanopore and Nanochannel Transport Studies
- Advanced Photocatalysis Techniques
- Prostate Cancer Treatment and Research
- Fuel Cells and Related Materials
- Advanced Memory and Neural Computing
- Nanomaterials for catalytic reactions
Institute of Chemistry of the Slovak Academy of Sciences
2019-2023
Slovak Academy of Sciences
2019-2023
Two-dimensional layered nanomaterial Ti3C2TX (a member of the MXene family) was used to immobilise enzyme sarcosine oxidase fabricate a nanostructured biosensor. The device applied for detection sarcosine, potential prostate cancer biomarker, in urine first time. morphology and structures have been characterised by atomic force microscopy (AFM) scanning electron (SEM). Electrochemical measurements, SEM AFM analysis revealed that interfaced with chitosan is an excellent support immobilisation...
Abstract MXenes are a new group of 2D nanomaterials with fascinating properties including high electrical conductivity, hydrophilic nature, easily tunable structure and surface area. This is why MXene modified interfaces extremely promising for the preparation sensitive electrochemical biosensors. While there numerous reports on MXene‐based enzymatic biosensors detection wide range analytes, application construction affinity in its infancy. The review article summarizes current state‐of...
Screen-printing technology is a game changer in many fields including electrochemical biosensing. Two-dimensional nanomaterial MXene Ti3C2Tx was integrated as nanoplatform to immobilise enzyme sarcosine oxidase (SOx) onto the interface of screen-printed carbon electrodes (SPCEs). A miniaturised, portable, and cost-effective nanobiosensor constructed using chitosan biocompatible glue for ultrasensitive detection prostate cancer biomarker sarcosine. The fabricated device characterised with...
For efficient and effective utilization of MXene such as biosensing or advanced applications interfacial modification needs to be considered. To this end, we describe Ti3C2Tx by aryldiazonium-based grafting with derivatives bearing a sulfo- (SB) carboxy-(CB) betaine pendant moiety. Since contains free electrons, could grafted spontaneously. Kinetics spontaneous SB CB towards was electrochemically examined in two different ways experiments confirmed much quicker compared grafting. Moreover,...
The glycoprofiling of two proteins, the free form prostate-specific antigen (fPSA) and zinc-α-2-glycoprotein (ZA2G), was assessed to determine their suitability as prostate cancer (PCa) biomarkers. proteins performed by analysing changes in glycan composition on fPSA ZA2G using lectins (proteins that recognise glycans, i . e complex carbohydrates). specific magnetic beads (MBs) modified with horseradish peroxidase (HRP) antibodies selectively enriched or from human serum samples....
Abstract Exosomes are naturally produced biological nanoparticles secreted by cells into body fluids and responsible for intercellular communication. can also carry cargo affecting neighbouring forming pre‐metastatic niches. Hence, exosomes behind localised tumour development, progression, but the induction of distant tumours metastasis. A substantially higher cellular activity results in production a greater number than normal, healthy cells. Therefore, present serve as good diagnostic...
The review initially provides a short introduction to prostate cancer (PCa) incidence, mortality, and diagnostics. Next, the need for novel biomarkers PCa diagnostics is briefly discussed. core of details about aetiology, alternative available besides specific antigen their biosensing. In particular, low molecular mass biomolecules (ions metabolites) high (proteins, RNA, DNA, glycoproteins, enzymes) are discussed, along with clinical performance parameters.
The article describes preparation, characterization and further modification of hybrid magnetic particles (Au nanoshells with a core (MPs@silica@Au)) by zwitterionic molecules bearing diazonium functional groups. Such modified exhibit the following features:•Responsiveness towards external field applicable for various enrichment strategies due to core;•Golden outer layer exhibiting free surface plasmons could be used grafting via functionality;•Zwitterionic interface on such provides...
Abstract Invited for this month's cover picture is the group of Dr. Jan Tkac (head Department Glycobiotechnology at Institute Chemistry Slovak Academy Sciences, Slovakia). The shows a common eukaryotic cell with basic organelles, as well intracellular formation/preparation exosomes express delivery to distant tissues. Read full text Review 10.1002/celc.202000075 .
In this work, two-dimensional layered material Ti3C2TX MXene has been used to immobilize enzyme sarcosine oxidase fabricate a nanostructured biosensor.The device was applied for detection of sarcosine, potential prostate cancer biomarker, in urine samples the first time.The morphology and structures have characterised by atomic force microscopy (AFM) scanning electron (SEM).Electrochemical, SEM AFM results revealed that along with chitosan is good candidate immobilization sensitive...
Abstract The glycoprofiling of two proteins, the free form prostate-specific antigen (fPSA) and zinc-α-2-glycoprotein (ZA2G), was assessed to determine their suitability as prostate cancer (PCa) biomarkers. proteins performed by analysing changes in glycan composition on fPSA ZA2G using lectins (proteins recognising glycans, i.e . complex carbohydrates). specific magnetic beads (MBs) modified with horseradish peroxidase (HRP) antibodies that selectively enriched or from human serum samples....
2D MXenes as Perspective Immobilization Platforms for Design of Electrochemical Nanobiosensors. More details can be found in the Full Paper by Lenca Lorencova et al. (DOI: 10.1002/elan.201900288).