A5037267836- Osteoarthritis Treatment and Mechanisms
- Veterinary Equine Medical Research
- Lubricants and Their Additives
- Tendon Structure and Treatment
- Lower Extremity Biomechanics and Pathologies
- Metal and Thin Film Mechanics
- Musculoskeletal synovial abnormalities and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Pharmaceutical studies and practices
- Knee injuries and reconstruction techniques
- Force Microscopy Techniques and Applications
- Electrocatalysts for Energy Conversion
- Gastrointestinal motility and disorders
- Inflammatory mediators and NSAID effects
- Gear and Bearing Dynamics Analysis
- Catalysis and Oxidation Reactions
- Catalytic Processes in Materials Science
- Proteoglycans and glycosaminoglycans research
Cornell University
2021-2025
Massachusetts Institute of Technology
2019
Indian Institute of Science Bangalore
2016
Removal of excess amount hydrogen in a catalytic route is safety measure to be implemented fuel cell technologies and nuclear power plants. Hydrogen oxygen activation are crucial steps for combustion that can achieved by modifying supports with suitable noble metals. In the present study, Pt- Pd-substituted Co3O4-ZrO2 (CZ) were synthesized using PEG-assisted sonochemical synthesis. Ionic states Pt Pd CZ analyzed X-ray photoelectron spectroscopy. improved H2 O2 extensively, which reduced...
A retrievable device, compatible with nasogastric tube administration, releases grams of drug over weeks while residing in the stomach.
Abstract Intra‐articular injections of hyaluronic acid have been a mainstay osteoarthritis treatment for decades. However, controversy surrounds the mechanism action and efficacy this therapy. As such, there has recent interest in developing synthetic lubricants that lubricate cartilage. Recently, 4 wt% polyacrylamide (pAAm) hydrogel was shown to effectively decrease lameness horses. its ability cartilage is unknown. The goal study characterize lubricating determine healthy degraded utilized...
Inflammation of the synovium, known as synovitis, plays an important role in pathogenesis osteoarthritis (OA). Synovitis involves release a wide variety pro-inflammatory mediators synovial fluid (SF) that damage articular cartilage extracellular matrix and induce death apoptosis chondrocytes. The composition is dramatically altered by inflammation OA, with changes to both hyaluronic acid lubricin, primary lubricating molecules SF. However, relationship between key biochemical markers joint...
ABSTRACT Lubricin, a lubricating glycoprotein abundant in synovial fluid, forms low-friction brush polymer interface tissues exposed to sliding motion including joints, tendon sheaths, and the surface of eye. Despite its therapeutic potential diseases such as osteoarthritis dry eye disease, there are few sources available. Through rational design, we developed series recombinant lubricin analogs that utilize species-specific tissue-binding domains at N- C-termini increase biocompatibility...
Abstract Osteochondral lesions (OCL) are common among young patients and often require surgical interventions since cartilage has a poor capacity for self-repair. Bone marrow stimulation (BMS) been used clinically decades to treat OCLs, however persisting challenge with BMS other repair strategies is the inferior quality of resulting fibrocartilaginous tissue. Lubrication-based therapies have potential improve tissue as joint lubrication linked local strains subsequent cellular responses...
Progressive cartilage degradation, synovial inflammation, and joint lubrication dysfunction are key markers of osteoarthritis. The composition fluid (SF) is altered in OA, with changes to both hyaluronic acid lubricin, the primary lubricating molecules SF. Lubricin's distinct bottlebrush mucin domain has been speculated contribute its ability, but relationship between structure mechanical function SF not well understood. Here, we demonstrate application a novel mucinase (StcE) selectively...
The low friction nature of articular cartilage has been attributed to the synergistic interaction between lubricin and hyaluronic acid in synovial fluid (SF). Lubricin is a mucinous glycoprotein that lowers boundary mode coefficient dose-dependent manner. While there have multiple attempts produce recombinant mimetic lubricants over last two decades, these materials not found clinical use due challenges associated with large scale production, manufacturing, purification. Recently, novel...
Intra-articular injections of hyaluronic acid (HA) are the cornerstone osteoarthritis (OA) treatments. However, mechanism action and efficacy HA viscosupplementation debated. As such, there has been recent interest in developing synthetic viscosupplements. Recently, a 4 wt% polyacrylamide (pAAm) hydrogel was shown to effectively lubricate bind surface cartilage vitro. its ability localize alter tribological properties tissue live articulating large animal joint is not known. The goal this...