A5085350815- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Geometric and Algebraic Topology
- Congenital Diaphragmatic Hernia Studies
- RNA Interference and Gene Delivery
- Infection Control and Ventilation
- Advanced Combinatorial Mathematics
- Ultrasound and Hyperthermia Applications
- Neonatal Respiratory Health Research
- Algebraic Geometry and Number Theory
- Lipid Membrane Structure and Behavior
- COVID-19 and healthcare impacts
- Viral gastroenteritis research and epidemiology
- Inhalation and Respiratory Drug Delivery
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Business Law and Ethics
- Topological and Geometric Data Analysis
- Gastrointestinal motility and disorders
- HIV Research and Treatment
- Parasites and Host Interactions
- Transplantation: Methods and Outcomes
- Wireless Body Area Networks
- Gastrointestinal Bleeding Diagnosis and Treatment
- Microfluidic and Capillary Electrophoresis Applications
University of Delaware
2020-2022
Massachusetts Institute of Technology
2016-2021
A newly developed platform capable of oral, ultra–long-acting drug delivery could be applied against the malaria vector in elimination programs.
Abstract The efficacy of antiretroviral therapy is significantly compromised by medication non-adherence. Long-acting enteral systems that can ease the burden daily adherence have not yet been developed. Here we describe an oral dosage form composed distinct drug–polymer matrices which achieved week-long systemic drug levels antiretrovirals dolutegravir, rilpivirine and cabotegravir in a pig. Simulations viral dynamics patient patterns indicate such would reduce therapeutic failures...
Microneedles with high drug-loaded tips allow fast and painless delivery of biologics into the buccal mucosa.
Long-term implantation of biomedical electronics into the human body enables advanced diagnostic and therapeutic functionalities. However, most long-term resident devices require invasive procedures for as well a specialized receiver communication. Here, gastric electronic (GRE) system that leverages anatomical space offered by environment to enable residence an orally delivered platform such within is presented. The GRE capable directly interfacing with portable consumer personal through...
A retrievable device, compatible with nasogastric tube administration, releases grams of drug over weeks while residing in the stomach.
Organ-on-chip (OOC) technologies, also called microphysiological systems (MPS), offer dynamic microenvironments that improve upon static culture systems, yet widespread adoption has been hindered by fabrication complexity, reliance on polydimethylsiloxane (PDMS), and limited modularity. Here, we present a modular MPS platform designed for ease of use, reproducibility, broad applicability. The system comprises layered elastomeric inserts dual monolayer cell culture, which is clamped within...
Geochemical reactive transport processes in natural mineral–fluid systems may produce a wide array of emergent phenomena that are difficult to predict from basic principles and reproduce model systems. Here, we present experimental results obtained simple microfluidic system with which explored the consequences reacting calcite (104) cleavage surface an acidic Pb-bearing solution (pH = 3.5, [Pb]total 5 mM) as function flow rate. This is relevant passive remediation for Pb-rich acid mine...
Abstract Premature birth interrupts the development of lung, resulting in functional deficiencies and onset complex pathologies, like bronchopulmonary dysplasia (BPD), that further decrease capabilities immature lung. The dysregulation molecular targets has been implicated presentation BPD, but there is currently no method to correlate resultant morphological changes observed tissue histology with these perturbations differences function throughout saccular alveolar lung development. Lung...
ABSTRACT As the current COVID-19 pandemic illustrates, not all hospitals and other facilities are equipped with enough personal protective equipment to meet demand in a crisis. Healthcare workers around world utilize N95 masks protect themselves their patients, yet during this global they forced re-wear what is intended be single-use masks. This poses significant risk these healthcare along populations trying protect. Ultraviolet germicidal irradiation (UVGI) has been validated previously as...
We prove that the $k$th term of Johnson filtration a closed, orientable surface genus $g \geq 2$ has cohomological dimension $2g - 3$ for all $k and 2$. This answers question Farb Bestvina--Bux--Margalit.
We show that the complex of homologous curves a closed, oriented surface genus g is (g-3)--acyclic.
We prove that second rational homology of the Torelli group an orientable closed surface genus g is finite dimensional for at least 51. This rules out simplest obstruction to being finitely presented and provides a partial answer question Bestvina.