A5075380514- Pulmonary Hypertension Research and Treatments
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transplantation: Methods and Outcomes
- Cystic Fibrosis Research Advances
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Issues in Pregnancy
- Tracheal and airway disorders
- Respiratory and Cough-Related Research
- Medical Imaging and Pathology Studies
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Pediatric health and respiratory diseases
- Eosinophilic Esophagitis
- Pneumonia and Respiratory Infections
- Polyomavirus and related diseases
- Liver Disease and Transplantation
- Heart Failure Treatment and Management
- Allergic Rhinitis and Sensitization
- Cardiovascular Function and Risk Factors
- SARS-CoV-2 and COVID-19 Research
- Renal Transplantation Outcomes and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Mechanical Circulatory Support Devices
Medizinische Hochschule Hannover
2016-2025
German Center for Lung Research
2016-2025
Hochschule Hannover
2025
Clinica de Pneumologie Iaşi
2022
L3S Research Center
2015
Deutsche Multiple Sklerose Gesellschaft
2012
Balloon pulmonary angioplasty (BPA) is an emerging treatment for patients with inoperable chronic thromboembolic hypertension (CTEPH). We report on a prospective series of 56 consecutive who underwent 266 BPA interventions (median, five per patient) at two German institutions. All comprehensive diagnostic work-up including right heart catheterisation baseline and 24 weeks after their last intervention. resulted in improvements WHO functional class, 6 min walk distance (mean change, +33 m),...
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) has spread around the world. Differentiation between pure viral COVID-19 pneumonia and secondary infection can be challenging. In patients with elevated C-reactive protein (CRP) on admission physicians often decide to prescribe antibiotic therapy. However, overuse of anti-infective therapy in pandemic should avoided prevent increasing antimicrobial resistance. Procalcitonin (PCT) CRP have proven...
Interleukin-5 (IL-5) antibodies represent a promising therapeutic option for patients with severe eosinophilic asthma. To date, no official treatment response criteria exist. In this study, simple applicable to all asthma were used evaluate clinical efficacy and predictors in real-life setting.Data from 42 treated mepolizumab at least six months analysed. Simple assess practice used: increase of FEV1 ≥ 12% or 200 ml, reduction blood eosinophils (< 150/μl < 80% baseline) improvement...
The incidence of chronic thromboembolic pulmonary hypertension (CTEPH) is unknown. Previous studies from the United Kingdom and Spain have reported rates 1.75 0.9 per million, respectively. These figures, however, may underestimate true CTEPH. We prospectively enrolled patients newly diagnosed with CTEPH within 2016 in Germany. Data were obtained three German referral centers branch COMPERA, a European registry. was calculated based on population data, patient characteristics treatment...
Symptomatic patients with residual pulmonary perfusion defects or vascular lesions but no hypertension at rest are diagnosed chronic thromboembolic disease (CTED). Balloon angioplasty (BPA) is an emerging treatment for inoperable (CTEPH), data regarding the safety and efficacy of BPA in CTED lacking. We report a prospective series ten consecutive who underwent 35 interventions (median four per patient) two German institutions. All comprehensive diagnostic workup baseline 24 weeks after their...
The role of mammalian target rapamycin (mTOR) inhibitors in de novo immunosuppression after lung transplantation is not well defined. We compared Everolimus versus mycophenolate mofetil an investigator-initiated single-center trial Hannover, Germany. A total 190 patients were randomly assigned 1:1 on day 28 posttransplantation to (MMF) or combined with cyclosporine (CsA) and steroids. Patients followed up for 2 years. primary endpoint was freedom from bronchiolitis obliterans syndrome (BOS)....
<b>Patients with clinically significant bronchiectasis featuring an eosinophilic inflammatory endotype who were treated add-on mepolizumab or benralizumab showed a improvement of FEV<sub>1</sub>, symptom burden and quality life</b>http://bit.ly/2AZvBLm
Patients after lung transplantation are at risk for life-threatening infections. Recently, several publications on COVID-19 outcomes in this patient population appeared, but knowledge optimal treatment, mortality, outcomes, and appropriate predictors is limited. A retrospective analysis was performed a German high-volume transplant center between 19 th March 2020 18 May 2021. Impact of physical psychological health, clinical mortality were analyzed including follow-up visits up to 12 weeks...
Currently an echocardiographic threshold for the tricuspid regurgitation gradient (TRG) of > 31 mmHg is recommended screening pulmonary hypertension (PH). Invasively diagnosed PH was recently redefined as mean arterial pressure (mPAP) 20 instead ≥ 25 mmHg. We investigated ability TRG to screen new PH-definition.Retrospective assessment echocardiography and right heart catheterisation data from 1572 patients entering Giessen PH-Registry during 2008-2018. Accuracy different thresholds other...
Objective: Mental health may affect the quality of life (QoL) in patients with pulmonary arterial hypertension (PAH). However, mental disorders have not been systematically assessed these patients. We examined prevalence using structured interviews and determined their impact on QoL PAH. Methods: This study included 217 PAH from two German referral centers. Psychiatric were clinical interview for DSM-V. was WHO Quality Life questionnaire (short form). The diagnostic value Hospital Anxiety...
Identification of MS registries and databases that are currently in use Europe as well a detailed knowledge their content structure is important order to facilitate comprehensive analysis comparison data.National or were identified by literature search, from the results Barometer 2011 asking 33 national societies. A standardized questionnaire was developed sent registries' leaders, followed telephone interviews with them.Twenty identified, 13 completing seven being interviewed telephone....
Before the turn of century, pregnancy in women with pulmonary arterial hypertension (PAH) was associated maternal mortality rates 30% and neonatal 11%.1Weiss BM Zemp L Seifert B Hess OM. Outcome vascular disease pregnancy: a systematic overview from 1978 through 1996.J Am Coll Cardiol. 1998; 31: 1650-1657Crossref PubMed Scopus (444) Google Scholar In more recent series, despite improved management PAH, pregnancy-associated remained high, ranging 11% to 25%.2Luo J Shi H Xu Su W Li J....
Zusammenfassung Hintergrund Die Einführung monoklonaler Antikörper (Biologika) hat die Therapie des schweren Asthmas revolutioniert. Auch wenn Mehrheit der Patienten ein Ansprechen zeigt, kann dieses unterschiedlich ausgeprägt sein. Bislang sind Kriterien zur Beurteilung Ansprechens auf Biologika nicht einheitlich definiert. Ziel Definition von konkreten, einfachen und praxistauglichen Bewertung bei mit schwerem Asthma, um eine Entscheidungshilfe bzgl. Fortführung, Umstellung oder Beendigung...
Background Accurate immunosuppression is of critical importance in preventing rejection, while avoiding toxicity following lung transplantation. The mainstay immunosuppressants are calcineurin inhibitors, which require regular monitoring due to interactions with other medications and diet. Adherence patient knowledge vital can be improved through education. Education using tablet-computers was investigated. Objective To compare tablet-PC education conventional improving trough levels target...
Background: Anti-IL-5 antibodies represent an established therapy for severe eosinophilic asthma (SEA), but some patients show inadequate response. The objective of this study was to assess the effects a switch anti-IL-5Rα in with response anti-IL-5 therapy. Methods: In retrospective multi-centre, real-life study, we analysed all SEA switched from due or intolerability. Pulmonary function tests, blood gas analyses, control tests (ACT) and oral corticosteroid (OCS) usage were compared at...
To analyze demography, clinical signs, and survival of intensive care patients diagnosed with nonocclusive mesenteric ischemia (NOMI) to evaluate the effect a local intra-arterial prostaglandin therapy.Retrospective observational study screening 455 acute arterial perfusion disorder in tertiary hospital within past 8 years. Lastly, 32 NOMI were enrolled, which 11 received therapy. The diagnosis was based on presentation established biphasic computed tomography criteria. Clinical biochemical...
Purpose: Treatment of severe eosinophilic asthma (SEA) has been revolutionized by the development monoclonal antibodies targeting underlying immunological pathways asthma. Two most frequently used in clinical practice are mepolizumab, interleukin (IL) 5 and benralizumab, IL5 receptor alpha. The comparative treatment efficacy these remains unclear, particularly regarding long-term outcomes. Patients Methods: In this multicenter, retrospective study, we included 123 patients treated with...
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with significant mortality and morbidity. Approval of antifibrotic therapy has ameliorated progression, but response heterogeneous to date, adequate biomarkers predicting are lacking. In recent years metabolomic technology improved broadly applied in cancer research thus enabling its use other fields. Recently both aberrant metabolic lipidomic pathways have been described influence profibrotic responses. We aimed characterize the...
Bronchoscopy is an established procedure routinely used by pediatric pulmonologists. Despite its frequent application, data on complications and specific risk factors are scarce sometimes conflicting.The aim of this study was to evaluate frequency severity clearly defined bronchoscopy in children that occur both during after the procedure, identify potential factors.A retrospective single-center analysis 670 elective bronchoscopies 522 aged 0-17 years time period 2008-2012 performed....
In patients with pulmonary arterial hypertension who have an insufficient response to oral or inhaled therapies, current guidelines recommend the use of parenteral prostacyclin analogues, although efficacy this approach is unknown.This retrospective multicenter study evaluated received intravenous treprostinil as add-on therapy. The risk at baseline and follow-up (6-12 months after initiation treprostinil) was classified low, intermediate, high according recommendations. outcome measured...
(1) Background: In COVID-19 survivors there is an increased prevalence of pulmonary fibrosis which the underlying molecular mechanisms are poorly understood; (2) Methods: this multicentric study, n = 12 patients who succumbed to due progressive respiratory failure were assigned early and late group (death within ≤7 >7 days hospitalization, respectively) compared 11 healthy controls; mRNA protein expression as well biological pathway analysis performed gain insights into evolution...