A5012677355- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Obstructive Sleep Apnea Research
- Sleep and related disorders
- Spondyloarthritis Studies and Treatments
- Vasculitis and related conditions
- Sleep and Wakefulness Research
- Orthopedic Surgery and Rehabilitation
- Restless Legs Syndrome Research
- Peripheral Nerve Disorders
- Bone health and osteoporosis research
- Muscle metabolism and nutrition
- Otitis Media and Relapsing Polychondritis
- Systemic Sclerosis and Related Diseases
- Peripheral Neuropathies and Disorders
- Osteoarthritis Treatment and Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Respiratory and Cough-Related Research
- Nerve Injury and Rehabilitation
- Neuroscience of respiration and sleep
- Infectious Diseases and Tuberculosis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal synovial abnormalities and treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
University of Saskatchewan
2014-2024
Center for Rheumatology
2005-2022
Royal University Hospital
2006-2021
University of Regina
2016
University of Toronto
2013-2015
University of Ottawa
2015
University Health Network
2015
Mount Sinai Hospital
2015
University of Manitoba
2015
St Joseph's Health Care
2015
In 1891, Von Recklinghausen first established the association between development of osteoporosis in presence overt hyperthyroidism. Subsequent reports have demonstrated that BMD loss is common frank hyperthyroidism, and, to a lesser extent, subclinical presentations. With introduction antithyroid medication 1940s control biochemical accompanying bone disease became less clinically apparent as hyperthyroidism was more successfully treated medically. Consequently, impact above normal thyroid...
In Brief Objective: To use the 2003 International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria and to evaluate restless legs syndrome (RLS) prevalence in a rheumatoid arthritis (RA) osteoarthritis (OA) population. Further, we wished physician awareness of this disorder by as reflected preexisting diagnoses RLS these populations. Methods: This was questionnaire study Saskatchewan RA OA patients enrolled longitudinal database study. A data collection instrument, including...
Abstract Objective The aim of the present study was to evaluate whether rheumatoid arthritis (RA) patients followed longitudinally using video‐conferencing and inter‐professional care support have comparable disease control those in traditional in‐person rheumatology clinics. Methods This a randomized controlled trial for 85 RA allocated either follow‐up or video‐conferenced with urban‐based rheumatologists rural physical therapist examiners. Follow‐up every 3 months 9 months. Outcome...
ABSTRACT Purpose Our purpose was to examine the effects of 2 years creatine monohydrate supplementation and exercise on bone health in postmenopausal women. Methods 237 women (mean age 59y) were randomized receive (0.14 g·kg -1 ·day ) or placebo during a resistance training (3d/wk) walking (6d/wk) program for years. primary outcome femoral neck mineral density (BMD), with lumbar spine BMD, proximal femur geometric properties as secondary outcomes. Results Compared placebo, had no effect BMD...
Poor sleep health is increasingly recognized as contributing to decreased quality of life, increased morbidity/mortality and heightened pain perception. Our purpose in this study was observe the effect on parameters, specifically efficiency, rheumatoid arthritis (RA) patients treated with anti-tumor necrosis factor alpha (anti-TNF-α) therapy.This a prospective observational RA hypersomnolence/poor defined by Epworth Sleepiness Scale (ESS) Pittsburgh Sleep Quality Index (PSQI). Study...
Objective To provide the initial installment of a living guideline that will up-to-date guidance on pharmacological management patients with rheumatoid arthritis (RA) in Canada. Methods The Canadian Rheumatology Association (CRA) formed multidisciplinary panel composed rheumatologists, researchers, methodologists, and patients. In this first our guideline, developed recommendation for tapering biologic targeted synthetic disease-modifying antirheumatic drug (b/ts DMARD) therapy sustained...
There is increasing awareness of the importance sleep in health maintenance. Our primary objective was to evaluate prevalence excess daytime sleepiness a rheumatic disease patient population. Secondary objectives included evaluation abnormal quality and disorders.Consecutive Rheumatology clinic patients were invited participate self-administered questionnaire study. Included measures for pain, fatigue, global functioning, modified Health Assessment Questionnaire, Epworth Sleepiness Score...
Abstract Objective Subjective reports of sleep dysfunction are common in people with rheumatoid arthritis (RA). Our objective was to determine whether excess sleepiness RA is associated polysomnographic (PSG) abnormalities. Methods Twelve participants abnormal scores were identified clinic and age/gender matched normal Epworth Sleepiness Scale (ESS) scores. A total 25 recruited. All underwent overnight PSG studies measurement apnoea–hypopnoea indexes (AHI). Questionnaire instruments,...
Recent evidence suggests that women with gestational hypertension (GH) have a high rate of sleep disordered breathing (SDB), and treatment for even marginal SDB may improve blood pressure control in GH. We assessed whether the application could GH.This was single-center randomized study. Subjects underwent an unattended home-based diagnostic The study then repeated subjects wearing one two randomly assigned treatments: auto-titrating continuous positive airway (auto-CPAP) or mandibular...
Abstract Objectives The aim of the present study was to identify potential barriers for access medical and allied health services from perspective rural Northern Saskatchewan rheumatoid arthritis (RA) patients. Methods A total 100 adults with established RA, residing in Saskatchewan, were recruited two rheumatology practices. Structured interviews standardized scripts solicited patient perspectives on appointment waiting times, travel required satisfaction healthcare provision. Thematic...
To compare the effects of nine months exercise training and ibuprofen supplementation (given immeditately after sessions) on bone muscle in postmenopausal women.In a double-blind randomized trial, participants (females: n = 90, mean age 64.8, SD 4.3 years) were assigned (computer generated, double blind) to receive supervised resistance or stretching 3 days/week, (400 mg, post-exercise) placebo (i.e. 4 groups) for 9 months. In this proof-of-concept study sample size was halved from required...
Rheumatoid arthritis (RA) is a chronic inflammatory and destructive arthritis. Understanding the incidence prevalence of RA within province facilitates appropriate health care resource planning. To estimate incidence/prevalence over time for overall provincial population, specific age range categories, gender. Saskatchewan Provincial Administrative Health Databases (2001–2014) were utilized as data sources. Two case-definitions employed: 1) > three physician billing diagnoses, at least one...
The diagnosis of asthma is based on clinical symptoms, physical examination and pulmonary function tests, can be very challenging. Most patients with have a significant postbronchodilator response spirometry indicating airway hyperresponsiveness. However, having bronchodilator by itself not diagnostic asthma. definition 'significant' has also been controversial. Many respirologists use the American Thoracic Society (ATS) criteria 12% (provided it 200 mL or greater) improvement in forced...
Abstract Objective To identify early predictors of disease activity at 18 months in JIA using clinical and biomarker profiling. Methods Clinical data were collected diagnosis a prospective longitudinal inception cohort 82 children with non-systemic JIA, their ability to predict an active joint count 0, physician global assessment ≤1 cm, inactive by Wallace 2004 criteria later was assessed. Correlation-based feature selection ReliefF used shortlist random forest models trained outcomes....
Objective To develop best practice statements for the provision of virtual care in adult and pediatric rheumatology Canadian Rheumatology Association’s (CRA) Telehealth Working Group (TWG). Methods Four members TWG representing adult, pediatric, university-based, community practices defined scope project. A rapid literature review existing systematic reviews, policy documents, published abstracts on topic was conducted between April May 2021. The informed a candidate set 7 supporting...
Rheumatoid arthritis (RA) is a multisystem disease with complex immunologic pathophysiology. Likewise, sleep disorders can involve complicated interplay between the neurologic pathways, immune system, and respiratory system. Recent studies have shown an elevated prevalence of abnormalities in connective tissue compared to general population. Restless legs syndrome (RLS) may be present up 30% RA patients. These findings related cytokine release other immunomodulatory responses. TNF- α levels...
Agricultural workers have physically demanding occupations. In this study of Saskatchewan farmers, the authors examined (1) self-reported prevalence physician-diagnosed rheumatoid arthritis and osteoarthritis; (2) impact these chronic arthridities on engagement in physical tasks related to farming. This was conducted through a cross-sectional analysis baseline data from Farm Injury Cohort Study which 2,473 adult residents upon 1,216 farms participated. Collected survey included demographic...
To identify discrete clusters comprising clinical features and inflammatory biomarkers in children with JIA to determine cluster alignment categories.A Canadian prospective inception cohort 150 was evaluated at baseline (visit 1) after six months 2). Data included manifestations inflammation-related biomarkers. Probabilistic principal component analysis identified sets of composite variables, or components, from 191 original variables. discern new clinical-biomarker (clusters), Gaussian...
Resistance training with ibuprofen supplementation may improve musculoskeletal health in postmenopausal women. The study purpose was to determine the efficacy of resistance and on bone muscle properties women.Participants (n = 90, 65.3 ± 4.9 yr) were randomly assigned to: supervised or stretching (placebo-exercise) postexercise (400 mg) placebo for 3 d·wk (9 months). Baseline postintervention measurements included distal shaft scans forearm lower leg using peripheral quantitative computed...