A5067665879- Curcumin's Biomedical Applications
- Scientific Research and Studies
- Drug-Induced Hepatotoxicity and Protection
- Neurological Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Biochemical effects in animals
- Veterinary Medicine and Surgery
- Spaceflight effects on biology
- Phytochemical and Pharmacological Studies
- Pharmacogenetics and Drug Metabolism
- Medical and Biological Ozone Research
- Agriculture and Biological Studies
- Urological Disorders and Treatments
- Field-Flow Fractionation Techniques
- Selenium in Biological Systems
- Nanoparticles: synthesis and applications
- Anesthesia and Neurotoxicity Research
Kharkiv State Veterinary Academy
2020
The prostate gland in dogs is highly vulnerable to the action of negative pathogens due its structure and topography. Among numerous etiological factors development prostatitis, inflammatory processes oxidative stress play a predominant role, regardless whether condition bacterial, viral, or autoimmune origin. This study aimed assess protein metabolism redox balance indicators tissue with acute prostatitis. For biochemical analyses, samples were taken from 24 mixed-breed dogs, including...
Nanomicroelementology is the modern science of trace elements obtained using nanotechnology. Over past 20 years, its achievements have led to emergence many food additives and medicines containing metal nanoparticles (NPs). The leading role here belongs discovery zinc oxide NPs. They are widely used in cosmetic industries biomedical research, their annual synthesis has highest values among all nanomaterials. However, zinc-based NPs exhibit toxic effects, especially with prolonged...
Toxicological properties of zinc-based nanoparticles (NPs) encourage researchers to create new, safe, and environmentally friendly compounds this trace element. In article, we determined the parameters hepatotoxicity zinc carbonate hydroxide (ZnCH) NPs obtained by coprecipitation method. For purpose, in a chronic toxicological experiment on 25 male Wistar rats, activity liver indicator enzymes (ALT, AST, GGT, ALP) protein profile blood plasma were after administration various doses ZnCH for...
The liver is the central link of metabolic distribution almost all drugs and xenobiotics (foreign substances). In most cases, this process carried out without damage to itself or other organs. However, some substances are toxic produce metabolites that cause in a uniform, dose-dependent manner. addition, agents form fairly byproduct can damage. formation metabolite hepatocyte will lead direct cell with disruption intracellular function an indirect effect through immune-mediated membrane...
Male infertility is an urgent problem of veterinary reproductive medicine. According to the latest scientific trends, oxidative stress main pathogenetic mechanism its occurrence. It known that such common pathological conditions as heat and diabetes can lead disturbances in functional activity histoarchitectonics male gonads. To correct changes accompanying these conditions, many compounds with antioxidant properties, including nanostructured ones, have been proposed. Therefore, goal our...
Modern requirements for the welfare of domestic animals are focused not only on compliance with maintenance, feeding, but also ensuring a long active life animals, especially older ones – 8–10 years and more. The problems that practical veterinary andrology constantly faces due to age factor, hormonal metabolic changes quite often, long-term lack sexual use males, which lead occurrence reproductive pathologies, including prostate gland. main among these pathologies development hyperplasia,...
Creating a new drug for animals requires detailed preclinical studies of its active ingredient. The problem mineral element deficiency in and poultry, on the one hand, is due to their nutritional deficiency, other associated with low bioavailability compounds presented pharmaceutical market. Nanotechnologically synthesized substances are widely introduced world, which not only significantly increase such compounds, but also reduce toxicity macroform. Among them, most common zinc oxide –...
The pathogenetic mechanism of reproductive diseases is oxidative stress, which manifested by an increase in lipid peroxidation and a decrease antioxidant potential. aim the study was to develop method for correction biochemical changes body boars with toxicant-induced dysfunctions using drugs based on nanobiomaterials, reducing lipoperoxidation, neutralization toxic substances protection increasing animals endocrine activity stimulating their gonads. article presents results research...
Experimental research on male domestic animals (boars, bulls) proved the effectiveness of using complex drug ‘Karafand+OV,Zn’ to increase their reproductive capacity. This preparation contains carotenoids, biologically active substances from rhizome marsh calamus and nanoparticles orthovanadate gadolinium activated by europium zinc carbonate. It was observed that introduction increased activity antioxidant protection — catalase in serum erythrocytes boars 15.9% (p < 0.01) 11.4% 0.05),...