Abstract Hepatic fibrosis (HF) is involved in aggravated wound‐healing response as chronic liver injury. Extracellular vesicles (EVs) carrying microRNA (miR) have been reported therapeutic targets for diseases. In this study, we set out to explore whether adipose‐derived mesenchymal stem cells (ADMSCs)‐derived EVs containing miR‐150‐5p affect the progression of HF. Carbon tetrachloride (CCl 4 ) was firstly used induce HF mouse models C57BL/6J mice, and activation hepatic stellate (HSCs)...

For patients with choledocholithiasis, laparoscopic common bile duct exploration (LCBDE) is preferred over open surgery. Whether primary closure of the (CBD) should be performed upon completion choledochotomy remains unclear, and corresponding indications for have yet to fully identified. This study was evaluate safety feasibility CBD among elderly (≥ 70 years) after LCBDE.Patients choledocholithiasis who had undergone LCBDE between July 2014 December 2020 were retrospectively reviewed....

Choledochal cysts (CCs), known as congenital choledochal dilatations, are more prevalent in Asia. The majority of patients with abdominal symptoms diagnosed and treated during early childhood, which results a lower prevalence CCs adults. treatment choice for is complete cyst excision followed by choledochojejunostomy. Laparoscopic surgery now widely accepted than traditional open due to its smaller incisions, faster recovery, less postoperative pain. However, there few reports on...

To evaluate and compare the efficacy potential side effects of transabdominal preperitoneal repair (TAPP) total extraperitoneal (TEP) for inguinal hernia with mesothelial cysts uterine round ligament (IHMCURL) repair. Observational study. Place Duration Study: Department General Surgery, The Second Clinical Medical College Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong, China, from January 2018 to December 2023. Data on patient demographics, cyst characteristics, surgical...

Abstract Background Currently, an increasing number of robotic major hepatectomies for hepatocellular carcinoma (HCC) are being performed. Despite the advantages surgery over laparoscopic procedures, studies comparing with hepatectomy in terms short-term results remain scarce. This study was performed to compare and their intraoperative postoperative results. Methods Data regarding demographics 131 patients undergoing or between January 2017 March 2022 were retrieved from medical records...

Laparoscopic minimally invasive surgery has become the primary treatment for ventral hernias. The laparoscopic intraperitoneal on lay mesh (IPOM) plus approach abdominal wall hernias is most used procedure, while extended view totally extraperitoneal (e‑TEP) repair a newer option. This study aimed to compare effectiveness and complications of 2 procedures repair.This was retrospective comparative single-center done at Second Clinical Medical College, Jinan University Hospital (Shenzhen...

Abstract Difficult laparoscopic cholecystectomy (DLC) is difficult to precisely predict before operation. This observational cohort study aimed evaluate the predictive value of procalcitonin (PCT) for DLC in patients with acute cholecystitis (AC). A total 115 were included from January 2017 April 2018. Multiple logistic regression and receiver-operating characteristic (ROC) performed PCT levels DLC. Patients had significantly higher Tokyo Guidelines 2018 (TG18) grade ( P = 0.002) C-reactive...

To assess the therapeutic effects of emergency laparoscopic appendectomy (LA) in treating complicated appendicitis (CA) for elderly patients (defined as age 65 years and above). Methods: We conducted a retrospective study 115 with CA who underwent surgical therapy Affiliated Huizhou Hospital Sun Yat-Sun University, Huizhou, Guangdong Province, China between September 2014 August 2016. Of these, 59 consented to open (OA), LA was performed other 56 patients. The perioperative follow-up...

For sigmoid colon or rectal cancer, a definite consensus regarding the optimal level ligating inferior mesenteric artery (IMA) has not been reached. We performed this study to determine whether ligation significantly affected short-term and long-term outcomes of patients with cancer after curative laparoscopic surgery.Medical records who had undergone surgery between January 2008 December 2014 at Department Gastrointestinal Surgery, Guangdong Provincial Hospital Traditional Chinese Medicine...

Clinically relevant postoperative pancreatic fistula (CR-POPF) remains the most common neopathy after pancreatoduodenectomy (PD). An ideal pancreaticoenterostomy (PE) which can effectively reduce incidence of CR-POPF and its potential is needed. We aimed to assess efficacy our modified duct-to-mucosa PE in PD.From January 2011 December 2017, 233 consecutive patients with PD were retrospectively included from Shenzhen People's Hospital. After propensity score matching (PSM), there 82 both...

Background: Incarcerated obturator hernia (IOH) is a scarce type of acute surgical disease, but the mortality rate highest in abdominal hernias. The aim this study was to evaluate efficacy emergency exploratory laparotomy (EEL) treating incarcerated (IOH).Methods: We conducted retrospective 12 female patients with IOH underwent EEL between January 2014 and March 2016. variables which included patient characteristics, findings CT, operative time, postoperative complications, length hospital...

The fusion of computed tomography (CT) and ultrasound (US) image can enhance lesion detection ability improve the success rate liver interventional radiology. image-based methods encounter challenge registration initialization due to random scanning pose limited field view US. Existing automatic those used vessel geometric information intensity-based metric are sensitive parameters have low rate. learning-based require a large number registered datasets for training.The aim this study is...

Gallbladder torsion is very rare and easily misdiagnosed as biliary disease. It defined the rotation of gallbladder along axis cystic pedicle on mesentery. As involves artery, blood supply blocked, resulting in ischemia eventual necrosis. If misdiagnosis occurs treatment delayed, can develop into a lethal The typical imaging features this case are good learning resource for our young physicians, well providing rare, unusual current literature database.We present 19-year-old man. patient...

The risk of post-hepatectomy liver failure (PHLF) is difficult to predict preoperatively. Accurate preoperative assessment residual volume critical in PHLF. Three-dimensional (3D) imaging and intra-operative ultrasound (IOUS) offer significant advantages calculating have been widely used hepatectomy assessment. Our research aimed explore the accuracy 3D technique combining IOUS predicting PHLF after hepatectomy.We a retrospective study design analyze patients who underwent with combined...

Macrotrabecular-massive hepatocellular carcinoma (MTM-HCC) is a novel subtype of HCC, one eight distinct subtypes, that accounts for 5% all cases HCC and associated with worse prognosis. Preoperative diagnosis MTM-HCCs using imaging findings can facilitate patient treatment decision-making. The purpose this study was to describe computed tomography (CT) magnetic resonance (MRI) compare these histopathological features.This retrospective case-control performed at Shenzhen People's Hospital....

A detailed assessment of biliary tract anatomy is necessary for the successful reoperation hepatolithiasis. This study aimed to evaluate feasibility preoperative individualized surgical planning with three-dimensional (3D) imaging technique hepatolithiasis.This was a retrospective matched case-control study. From January 2011 December 2018, 56 patients receiving according plan based on 3D at our center were included (group A). Meanwhile, 54 traditional guided by age, gender and distribution...

Abstract Background For patients with choledocholithiasis, laparoscopic common bile duct exploration (LCBDE) is preferred over open surgery. Whether primary closure of (CBD) should be performed on completion choledochotomy and corresponding indications for are still controversial topics. This study was accomplished to evaluate safety feasibility CBD among elderly (≥ 70 years) after LCBDE. Methods Patients choledocholithiasis who had undergone LCBDE between July 2014 December 2020 were...

Three dimensional laparoscopy faciliated the precision manipulation in surgery.From November 2013 to January 2014,the computed tomography data of 16 patients with hepatobiliary diseases were reconstructed by abdominal medical image three visualization software (MI-3DVS) direct operation.The operation was done under laparoscope.Of patients,7 received laparoscopic cholecystectomy,5 liver cancer hepatectomy,3 hepatolithiasis pneumatic lithotripsy rigid choledochoscope,1 large cyst right...

Abstract Background: Despite the fact that most gallbladder polyps are benign, malignant lesions not so rare as thought. We performed this study to evaluate size distribution of and assess efficiency reported risk factors in predicting malignancy. Methods: In study, medical records patients having undergone laparoscopic cholecystectomy for at Department Hepatobiliary Pancreatic Surgery, Shenzhen People , s Hospital were reviewed. Chi-square test binary logistic regression analysis adopted...

The severe acute pancreatitis(SAP)is a prognostic dangerous disease,often leads to systemic inflammation response syndrome(SIRS)and multiple organ failure(MOF).The basis of iaflammation caused by SAP is composed many cytokines via the cell signaling pathway mediated in complex network.In this paper,we summarized recent research pathogenesis comprehensive analysis and summary relative literatures years at home abroad. Key words: cell signal pathways; acute pancreatitis; pathogenesis