A5038229756- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Management of metastatic bone disease
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Head and Neck Cancer Studies
- Palliative Care and End-of-Life Issues
- Cancer Genomics and Diagnostics
- Radiation Dose and Imaging
- Radiology practices and education
- Neuroendocrine Tumor Research Advances
- Advances in Oncology and Radiotherapy
- Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Cancer survivorship and care
- Cutaneous Melanoma Detection and Management
- Medical Imaging Techniques and Applications
- Oral health in cancer treatment
- Medical Imaging and Pathology Studies
- Bone health and treatments
Wake Forest University
2016-2025
Atrium Health Wake Forest Baptist
2015-2024
Wake Forest Baptist Comprehensive Cancer Center
2019-2021
Prisma Health
2021
University of Alabama at Birmingham
2021
Radiation Oncology Associates
2017
SUNY Upstate Medical University
2012
Areté Associates (United States)
2001-2002
Abstract BACKGROUND: Gamma Knife radiosurgery (GKRS) allows for the treatment of intracranial tumors with a high degree dose conformality and precision. There are, however, certain situations wherein GKRS is desired, but single-session contraindicated. In these situations, traditional pin-based head frame cannot be used, because it precludes fractionated treatment. OBJECTIVE: To report our experience in treating patients using relocatable, noninvasive immobilization system. METHODS: Patients...
Different types of therapy are currently being used to treat non-small cell lung cancer (NSCLC) depending on the stage tumor and presence potentially druggable mutations. However, few biomarkers available guide clinicians in selecting most effective for all patients with various genetic backgrounds. To examine whether patients' mutation profiles associated response a specific treatment, we collected comprehensive clinical characteristics sequencing data from 524 III IV NSCLC treated at...
The brain is one of the most common metastatic sites among breast cancer patients, especially in those who have Her2-positive or triple-negative tumors. microenvironment has been considered immune privileged, and exact mechanisms how cells contribute to metastasis remain elusive. In this study, we found that neutrophils are recruited influenced by c-Met high sites, depletion significantly suppressed animal models. Overexpression tumor enhances secretion a group cytokines, including CXCL1/2,...
Abstract Radiotherapy for prophylaxis of heterotopic ossification (HO) is commonly used in high risk patients following orthopedic surgery. While treatment effective and can prevent morbidity associated with HO, any dose radiation there a concern induced malignancy. Here we report case osteosarcoma which developed 11 years after single fraction 700 cGy. We performed dosimetric analysis by superimposing the patient’s original field on CT scan diagnosis. The radiotherapy this patient lower...
PURPOSE: Immunotherapy or chemoimmunotherapy is now standard treatment for most patients with metastatic non–small-cell lung cancer (mNSCLC), yet patient supportive care needs (SCNs) on immunotherapy are not well defined. This study characterized the SCNs and financial hardship of mNSCLC treated examined relationship between caregiver cancer-related employment reductions hardship. METHODS: Patients from a single academic medical center completed Survey-34, items indexing material,...
Abstract There is limited data on the effects of smoking lung cancer patients with brain metastases. This single institution retrospective study metastases from who received stereotactic radiosurgery assessed whether history associated overall survival, local control, rate new (brain metastasis velocity), and likelihood neurologic death after Patients were stratified by adenocarcinoma versus nonadenocarcinoma histologies. Kaplan–Meier analysis was performed for survival endpoints. Competing...
Abstract Treatment of non–small cell lung cancer (NSCLC) has drastically changed in recent years owing to the robust anticancer effects immune checkpoint inhibitors (ICI). However, only 20% patients with NSCLC benefit from ICIs, highlighting need uncover mechanisms mediating resistance. By analyzing overall survival (OS) and mutational profiles 424 who received ICI treatments between 2015 2021, we determined that carrying a loss-of-function mutation neurotrophic tyrosine kinase receptor 1...
Cartilage oligomeric matrix protein (COMP) is an extracellular that has recently been associated with worse patient outcomes in breast, prostate, colorectal and hepatocellular cancers. This study aimed to determine whether COMP was also increased progression resistance radiation non-small cell lung cancer (NSCLC). The proliferation, migration, invasion viability of wild-type overexpressing NSCLC lines were assessed when treated exogenous COMP, or without radiation. In addition, these cells...
Background/Objectives: No prior studies have attempted to identify a biomarker for initial brain metastasis velocity (iBMV), with limited attempting correlate genomic data the development of metastases. Methods: Patients non-small-cell lung cancer (NSCLC) who underwent next-generation sequencing (NGS) were identified in our departmental database. iBMV was calculated by dividing number BMs interval time between primary and BM diagnosis. Two-sample t-testing used mutations statistically...
In this report, we present the case of a 66-year-old man who received local consolidation radiotherapy to right lung and mediastinum for oligometastatic non-small cell cancer (NSCLC) following partial response upfront chemoimmunotherapy. He continued with maintenance immunotherapy was asymptomatic eight months after completing radiation therapy. then developed symptoms consistent pneumonitis within three five days his first administration coronavirus disease 2019 (COVID-19) vaccine...
Metastatic prostate cancer has a 5-year survival rate of 30%. Identifying predictors metastasis outcome could potentially reduce patient mortality. The objective this study was to determine whether osteoarthritis had an impact on outcomes including death, local recurrence and/or and cartilage oligomeric matrix protein involved. We performed retrospective case-control patients with without the diagnosis completed immunohistochemistry (IHC) analysis (n=20) lymph node (n=7) surgical specimens....