A5080036401- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Meningioma and schwannoma management
- Radiation Dose and Imaging
- Leprosy Research and Treatment
- Glioma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Effects of Radiation Exposure
- Trigeminal Neuralgia and Treatments
- Brain Metastases and Treatment
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Surgical Oncology
- Neurofibromatosis and Schwannoma Cases
- Mycobacterium research and diagnosis
- Advanced X-ray and CT Imaging
- Facial Nerve Paralysis Treatment and Research
- Tuberculosis Research and Epidemiology
- Vascular Malformations Diagnosis and Treatment
- Medical Image Segmentation Techniques
- Radiation Detection and Scintillator Technologies
- Lung Cancer Diagnosis and Treatment
- Radiation Effects and Dosimetry
- Blood groups and transfusion
- Immune Response and Inflammation
Wake Forest University
2015-2024
Atrium Health Wake Forest Baptist
2007-2020
Radiation Oncology Associates
2019
Washington University in St. Louis
2015
Emory University
2014
Cone Health
2012
Crowleys Ridge College
2012
Regional Cancer Center
2012
Mayo Clinic
1996
WinnMed
1992-1996
Abstract BACKGROUND: Gamma Knife radiosurgery (GKRS) allows for the treatment of intracranial tumors with a high degree dose conformality and precision. There are, however, certain situations wherein GKRS is desired, but single-session contraindicated. In these situations, traditional pin-based head frame cannot be used, because it precludes fractionated treatment. OBJECTIVE: To report our experience in treating patients using relocatable, noninvasive immobilization system. METHODS: Patients...
The American Association of Physicists in Medicine (AAPM) formed Task Group 178 (TG‐178) to perform the following tasks: review in‐phantom and in‐air calibration protocols for gamma stereotactic radiosurgery (GSR), suggest a dose rate protocol that can be successfully utilized with all (GSR) devices, update quality assurance (QA) TG‐42 (AAPM Report 54, 1995) static GSR devices. TG‐178 report recommends formalism provides tabulated data implement it ionization chambers commonly used...
A three‐dimensional dose computation model employing a finite‐size, diverging, pencil beam has been developed and is demonstrated for Cobalt‐60 γ rays. The square cross‐section simulated in semi‐infinite water phantom by convolving the photon fluence with Monte Carlo point kernel Cobalt‐60. This finite‐size calculated one time becomes new data base which to build larger beams two‐dimensional superposition. profile, angle correction divergence, Mayneord inverse correction, radial angular...
Purpose: In response to the increased risk of radiological terrorist attack, a network Centers for Medical Countermeasures against Radiation (CMCR) has been established in United States, focusing on evaluating animal model responses uniform, relatively homogenous whole- or partial-body radiation exposures at high dose rates. The success such studies is dependent not only robust models but accurate and reproducible dosimetry within across CMCR. To address this issue, Education Training Core...
This study investigated the integration of Calypso real-time tracking system, based on implanted ferromagnetic transponders and a detector array, into current process for image-guided radiation treatment (IGRT) prostate cancer at our institution. The IGRT includes magnetic resonance imaging (MRI) delineation, CT simulation planning, daily on-board kV CBCT target alignment, MRI/MRS post-treatment assessment. assesses (1) magnetic-field-induced displacement radio-frequency (RF)-induced heating...
Medications that can mitigate against radiation injury are limited. In this study, we investigated the ability of recombinant human growth hormone (rhGH) to in mice and nonhuman primates. BALB/c were irradiated with 7.5 Gy treated post-irradiation rhGH intravenously at a once daily dose 20 microg/dose for 35 days. protected 17 out 28 (60.7%) from lethal irradiation while only 3 (10.7%) survived saline control group. A shorter course 5 days produced similar results. Compared group, treatment...
This work merges two distinct fields, 3D morphology and ionizing radiation dosimetry, to solve the problem of 3D-treatment planning optimization in stereotactic radiosurgery. In Leksell Gamma Knife radiosurgery, dose delivery is based on unit "shot," a distribution approximately spherical shape. Multiple shots, or isocenters, are used treatment deliver conformal an irregular radiosurgical target. The medial axis transformation, skeleton, target, which uniquely characterizes target volume...
✓ Glossopharyngeal neuralgia (GPN) is a rare condition in which patients present with intractable deep throat pain. Similar to trigeminal (TN), treatment microvascular decompression (MVD) has been successful both. Because gamma knife surgery (GKS) also shown be effective treating TN, it seemed reasonable apply GPN. The authors the first report of GKS-treated GPN patient who presented severe, poorly controlled and refused MVD.
To test iron-containing multiwalled carbon nanotubes (MWCNTs) as bifunctional nanomaterials for imaging and thermal ablation of tumors.MWCNTs entrapping iron were synthesized by chemical vapor deposition. The T2-weighted contrast enhancement properties MWCNTs containing increasing amounts determined in vitro. Suspensions these particles injected into tumor-bearing mice tracked longitudinally over 7 days MRI. Heat-generating abilities following exposure to near infrared (NIR) laser...
The purpose of this study was to evaluate patterns failure after stereotactic radiosurgery (SRS) for meningiomas and factors that may influence these outcomes.Based on a retrospective chart review, 279 patients were treated with SRS between January 1999 March 2011 at Wake Forest Baptist Health. Disease progression determined using serial imaging, minimum follow-up 6 months (median 34.2 months).The median margin dose 12.0 Gy (range 8.8-20 Gy). Local control rates WHO Grade I tumors 96.6%,...
Gamma Knife surgery (GKS) is a treatment option for patients with refractory typical trigeminal neuralgia (TN), TN atypical features, and types of facial pain. The Knife's 201 60Co sources decay half-life 5.26 years. authors examined whether the decrease in dose rate over 4.6 years between Co source replacements affected control rates pain undergoing GKS.The collected complete follow-up data on 239 326 GKS procedures performed Patients were classified by their type isocenter 4-mm collimator...
Purpose: To assess early changes in brain metastasis response to whole radiotherapy (WBRT) by longitudinal Magnetic Resonance Imaging (MRI).Materials and methods: Using a 7T system, MRI examinations of metastases breast cancer MDA-MD231-Br mouse model were conducted before 24 hours after 3 daily fractionations 4 Gy WBRT. Besides anatomic MRI, diffusion-weighted (DW) dynamic contrast-enhanced (DCE) applied study cytotoxic effect blood-tumor-barrier (BTB) permeability change,...
Ionizing radiation causes acute damage to hematopoietic and immune cells, but the long-term immunologic consequences of irradiation are poorly understood. We therefore performed a prospective study delayed effects using rhesus macaque model.
The use of positron emission tomography (PET) imaging has proved beneficial in the staging and diagnosis several cancer disease sites. Additional applications PET treatment planning evaluation response are limited by relatively low spatial resolution images. Including point spread function (PSF) information system matrix (SM) iterative reconstruction techniques been shown to produce improved images.In this study, authors sampled spatially variant PSF at over 6000 locations field view for a...