A5010064496- Maternal Mental Health During Pregnancy and Postpartum
- Birth, Development, and Health
- Child and Adolescent Psychosocial and Emotional Development
- Infant Development and Preterm Care
- Child Abuse and Trauma
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Health, Environment, Cognitive Aging
- Breastfeeding Practices and Influences
- Climate Change and Health Impacts
- Frailty in Older Adults
- Attachment and Relationship Dynamics
- Nutrition and Health in Aging
- Neonatal and fetal brain pathology
- Infant Nutrition and Health
- Child Nutrition and Feeding Issues
- Child Nutrition and Water Access
- Intergenerational Family Dynamics and Caregiving
Amsterdam University Medical Centers
2018-2022
University of Amsterdam
2018-2022
Amsterdam UMC Location University of Amsterdam
2017-2020
Purpose The Dutch famine birth cohort study was set up to investigate the effects of acute maternal undernutrition 1944–1945 during specific stages gestation on later health, with a particular focus chronic cardiovascular and metabolic diseases, ageing mental health. Participants consists 2414 singletons born alive at term in Wilhelmina Gasthuis Amsterdam around time (1943–1947) whose records have been kept. has traced studied since 1994, when first data collection started. interviewed...
This paper describes the findings of a historical cohort study men and women born around time Dutch famine 1944-45. It provided first direct evidence in humans lasting consequences prenatal undernutrition. The effects undernutrition depended on its timing during gestation, organs tissues undergoing periods rapid development at that time. Early gestation appeared to be particularly critical, with being most apparent, even without reductions size birth. Undernutrition affected structure...
There is evidence suggesting that the aging process has its origins in utero. We have previously shown prenatal exposure to Dutch famine associated with chronic noncommunicable diseases and poorer cognitive function men women increased mortality women. investigated whether undernutrition during early gestation decreased physical later life. Between November 2012 September 2013, we studied a random subsample of 150 members birth cohort at age 68 years, which 49 were exposed undernutrition. In...
Abstract Effective treatment of maternal antenatal depression may ameliorate adverse neurodevelopmental outcomes in offspring. We performed two follow-up rounds children at age 2 and 5 whose mothers had received either specialized cognitive-behavioural therapy or routine care for while pregnant. Of the original cohort 54 women, renewed consent was given by 28 women 2-year 24 5-year follow-up. Child assessments included Parenting Stress Index (PSI), Bayley Scales Infant Development (BSID-III)...
There is increasing interest for the potential harmful effects of prenatal stress on developing fetal brain, both in scientific literature and public press. Results from animal studies suggest that gestational leads to an altered offspring neurodevelopment with adverse behavioral cognitive consequences. Furthermore, there are indications human severe has negative consequences child's neurodevelopment. However, umbrella term maternal have focused a wide range inducing situations, ranging...
Children prenatally exposed to maternal depression more often show behavioral and emotional problems compared unexposed children, possibly through epigenetic alterations. Current evidence is largely based on animal observational human studies. Therefore, from experimental studies needed. In this follow-up of a small randomized controlled trial (RCT), DNA-methylation was between children women who had received cognitive therapy (CBT) for antenatal treatment as usual (TAU). Originally, 54 were...
Purpose of review: We describe the evidence on associations between prenatal depression and child neurodevelopmental outcomes we critically evaluate results one first randomized controlled trials effects antenatal Cognitive Behavioural Therapy for anxiety buccal cell DNA-methylation, brain morphology, behaviour cognition approximately 5 years postpartum.
Antenatal depression is associated with an increased risk of offspring neuro-developmental disorders, potentially as a consequence altered brain development in utero. We hypothesized that reducing maternal by Cognitive Behavioral Therapy (CBT) during pregnancy may ameliorate the offspring’s (micro)structural outcomes. 54 pregnant women diagnosed clinical were randomly allocated to CBT or Treatment Usual (TAU), showing moderate large symptom improvements after CBT. In 16 their children (69%...
There are few studies of cognitive behavioral therapy for women with antenatal depression including qualitative and quantitative data, yet, individual cases can provide valuable information on personal experiences treatment effectiveness acceptability. The purpose this case report is to explore the long-term outcomes following depression. A pregnant woman a Diagnostic Statistical Manual Mental Disorders diagnosis was allocated receive seven sessions in randomized controlled trial. We...