Flavio Alvarez

ORCID: 0000-0003-2950-7035
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About
Contact & Profiles
Research Areas
  • SARS-CoV-2 and COVID-19 Research
  • Long-Term Effects of COVID-19
  • Olfactory and Sensory Function Studies
  • Endoplasmic Reticulum Stress and Disease
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Bacillus and Francisella bacterial research
  • Heat shock proteins research
  • Viral Infections and Outbreaks Research
  • Vagus Nerve Stimulation Research
  • Infectious Encephalopathies and Encephalitis
  • interferon and immune responses

Université Paris Cité
2021-2024

Institut Pasteur
2021-2024

Sorbonne Université
2022-2024

Centre National de la Recherche Scientifique
2021-2023

Université Sorbonne Nouvelle
2022

Abstract Anosmia was identified as a hallmark of COVID-19 early in the pandemic, however, with emergence variants concern, clinical profile induced by SARS-CoV-2 infection has changed, anosmia being less frequent. Here, we assessed clinical, olfactory and neuroinflammatory conditions golden hamsters infected original Wuhan strain, its isogenic ORF7-deletion mutant three variants: Gamma, Delta, Omicron/BA.1. We show that animals develop variant-dependent disease including anosmia, ORF7...

10.1038/s41467-023-40228-7 article EN cc-by Nature Communications 2023-07-26

The C-terminus of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein E contains a PBM (PDZ-binding motif) targeting PDZ (PSD-95/Dlg/ZO-1) domains, which is identical to SARS-CoV. latter involved in pathogenicity virus. Recently, we identified 10 human PDZ-containing proteins showing significant interactions with SARS-CoV-2 PBM. We selected several them cellular junctions and cell polarity (TJP1, PARD3, MLLT4, LNX2) MPP5/PALS1 previously shown interact SARS-CoV Targeting...

10.3389/fmicb.2022.829094 article EN cc-by Frontiers in Microbiology 2022-02-23

The carboxy-terminal tail of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope protein (E) contains a PDZ-binding motif (PBM) which is crucial for pathogenicity. During SARS-CoV-2 infection, viral E expressed within Golgi apparatus membrane host cells with its PBM facing cytoplasm. In this work, we study molecular mechanisms controlling presentation to PDZ (PSD-95/Dlg/ZO-1) domain-containing proteins. We show that at level apparatus, not detected by C-terminal...

10.1016/j.jbc.2023.105575 article EN cc-by-nc-nd Journal of Biological Chemistry 2023-12-17

Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19 pandemic, has significantly impacted global health, emphasizing need to understand its pathogenicity and virulence mechanisms. SARS-CoV-2 disrupts alveolar epithelial barrier exacerbates airway inflammation, leading acute respiratory failure, but molecular details remain unclear. Additionally, infection causes neurological symptoms, potentially due weakly understood ability cross...

10.1101/2024.12.10.627528 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-12-10

SUMMARY Anosmia was identified as a hallmark of COVID-19 early in the pandemic, however, with emergence variants concern, clinical profile induced by SARS-CoV-2 infection has changed, anosmia being less frequent. Here, we assessed clinical, olfactory and neuroinflammatory conditions golden hamsters infected original Wuhan strain, its isogenic ORF7-deletion mutant three variants: Gamma, Delta, Omicron/BA.1. We show that animals developed variant-dependent disease including anosmia, ORF7...

10.1101/2022.08.31.505985 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2022-08-31

Abstract The C-terminus of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein E contains a PBM (PDZ binding motif) targeting PDZ (PSD-95/Dlg/ZO-1) domains identical to SARS-CoV. latter is involved in pathogenicity virus. Recently, we identified ten human PDZ-containing proteins showing significant interactions with SARS-CoV-2 PBM. We selected several them cellular junctions and cell polarity (TJP1, PARD3, MLLT4, LNX2) MPP5/Pals1 previously shown interact SARS-CoV...

10.1101/2021.12.04.471219 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2021-12-06

Abstract The carboxy terminal tail of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope protein (E) contains a PDZ-binding motif (PBM) which is crucial for pathogenicity. During SARS-CoV-2 infection, viral E expressed within Golgi apparatus membrane host cells with its PBM facing cytoplasm. In this work we study molecular mechanisms controlling presentation to PDZ (PSD-95/Dlg/ZO-1) domain-containing proteins. We show that at level apparatus, not detected by C-terminal...

10.1101/2023.08.29.555304 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2023-08-29
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