A5087581991- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Olfactory and Sensory Function Studies
- Endoplasmic Reticulum Stress and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Bacillus and Francisella bacterial research
- Heat shock proteins research
- Viral Infections and Outbreaks Research
- Vagus Nerve Stimulation Research
- Infectious Encephalopathies and Encephalitis
- interferon and immune responses
Université Paris Cité
2021-2024
Institut Pasteur
2021-2024
Sorbonne Université
2022-2024
Centre National de la Recherche Scientifique
2021-2023
Université Sorbonne Nouvelle
2022
Abstract Anosmia was identified as a hallmark of COVID-19 early in the pandemic, however, with emergence variants concern, clinical profile induced by SARS-CoV-2 infection has changed, anosmia being less frequent. Here, we assessed clinical, olfactory and neuroinflammatory conditions golden hamsters infected original Wuhan strain, its isogenic ORF7-deletion mutant three variants: Gamma, Delta, Omicron/BA.1. We show that animals develop variant-dependent disease including anosmia, ORF7...
The C-terminus of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein E contains a PBM (PDZ-binding motif) targeting PDZ (PSD-95/Dlg/ZO-1) domains, which is identical to SARS-CoV. latter involved in pathogenicity virus. Recently, we identified 10 human PDZ-containing proteins showing significant interactions with SARS-CoV-2 PBM. We selected several them cellular junctions and cell polarity (TJP1, PARD3, MLLT4, LNX2) MPP5/PALS1 previously shown interact SARS-CoV Targeting...
The carboxy-terminal tail of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope protein (E) contains a PDZ-binding motif (PBM) which is crucial for pathogenicity. During SARS-CoV-2 infection, viral E expressed within Golgi apparatus membrane host cells with its PBM facing cytoplasm. In this work, we study molecular mechanisms controlling presentation to PDZ (PSD-95/Dlg/ZO-1) domain-containing proteins. We show that at level apparatus, not detected by C-terminal...
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19 pandemic, has significantly impacted global health, emphasizing need to understand its pathogenicity and virulence mechanisms. SARS-CoV-2 disrupts alveolar epithelial barrier exacerbates airway inflammation, leading acute respiratory failure, but molecular details remain unclear. Additionally, infection causes neurological symptoms, potentially due weakly understood ability cross...
SUMMARY Anosmia was identified as a hallmark of COVID-19 early in the pandemic, however, with emergence variants concern, clinical profile induced by SARS-CoV-2 infection has changed, anosmia being less frequent. Here, we assessed clinical, olfactory and neuroinflammatory conditions golden hamsters infected original Wuhan strain, its isogenic ORF7-deletion mutant three variants: Gamma, Delta, Omicron/BA.1. We show that animals developed variant-dependent disease including anosmia, ORF7...
Abstract The C-terminus of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein E contains a PBM (PDZ binding motif) targeting PDZ (PSD-95/Dlg/ZO-1) domains identical to SARS-CoV. latter is involved in pathogenicity virus. Recently, we identified ten human PDZ-containing proteins showing significant interactions with SARS-CoV-2 PBM. We selected several them cellular junctions and cell polarity (TJP1, PARD3, MLLT4, LNX2) MPP5/Pals1 previously shown interact SARS-CoV...
Abstract The carboxy terminal tail of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope protein (E) contains a PDZ-binding motif (PBM) which is crucial for pathogenicity. During SARS-CoV-2 infection, viral E expressed within Golgi apparatus membrane host cells with its PBM facing cytoplasm. In this work we study molecular mechanisms controlling presentation to PDZ (PSD-95/Dlg/ZO-1) domain-containing proteins. We show that at level apparatus, not detected by C-terminal...