A5010440820- Magnetic and Electromagnetic Effects
- Characterization and Applications of Magnetic Nanoparticles
- Medical Imaging and Analysis
- Circadian rhythm and melatonin
- Geomagnetism and Paleomagnetism Studies
- Photoreceptor and optogenetics research
- Mechanical and Optical Resonators
- Cervical and Thoracic Myelopathy
- Neuroendocrine regulation and behavior
- Advanced biosensing and bioanalysis techniques
- Stress Responses and Cortisol
- Analytical Chemistry and Sensors
- Spine and Intervertebral Disc Pathology
- Erythrocyte Function and Pathophysiology
- Magnetic properties of thin films
- Lung Cancer Research Studies
- Advanced Electron Microscopy Techniques and Applications
- Molecular Communication and Nanonetworks
- Advanced Memory and Neural Computing
- Electrochemical sensors and biosensors
- Force Microscopy Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Biosensors and Analytical Detection
- Glioma Diagnosis and Treatment
- Electromagnetic Fields and Biological Effects
Massachusetts Institute of Technology
2014-2022
McGovern Institute for Brain Research
2019-2022
Brigham and Women's Hospital
2021-2022
Harvard University
2021-2022
Leiden University Medical Center
2021
Cornell University
2012
Magnetic nanomaterials in magnetic fields can serve as versatile transducers for remote interrogation of cell functions. In this study, we leveraged the transition from vortex to in-plane magnetization iron oxide nanodiscs modulate activity mechanosensory cells. When a configuration spins is present nanomaterials, it enables rapid control over their direction and magnitude. The manifests near zero net moment absence field, affording greater colloidal stability suspensions. Together, these...
Remote magnetic modulation of adrenal cell calcium in the presence nanoparticles enables on-demand hormone release.
The tools for optically imaging cellular potassium concentrations in real-time are currently limited to a small set of molecular indicator dyes. Quantum dot-based nanosensors more photostable and tunable than organic indicators, but previous designs have fallen short size, sensitivity, selectivity. Here, we introduce small, sensitive, selective nanosensor measurements. A dynamic quencher modulates the fluorescence emitted by two different quantum dot species produce ratiometric signal. We...
Detection of magnetic resonance as a force between tip and nuclear spins has previously been shown to enable sub-10 nm resolution 1H imaging. Maximizing the spin in such microscopy (MRFM) experiment demands high field gradient. In order study wide range samples, it is equally desirable locate on sensor. Here we report development attonewton-sensitivity cantilevers with high-gradient cobalt nanomagnet tips. The damage layer thickness saturation magnetization material were characterized by...
Selective hysteretic heating of multiple collocated sets single domain magnetic nanoparticles (SDMNPs) by alternating fields (AMFs) may offer a useful tool for biomedical applications. The possibility magnetothermal multiplexing has not yet been realized, in part due to prevalent use linear response theory model SDMNP AMFs. Predictive successes dynamic hysteresis (DH), more generalized heat dissipation SDMNPs, are observed experimentally with detailed calorimetry measurements performed at...
Background Patients who undergo surgery for cervical radiculopathy are at risk developing adjacent segment disease (ASD). Identifying patients will develop ASD remains challenging clinicians. Purpose To and validate a deep learning algorithm capable of predicting by using only preoperative MRI in undergoing single-level anterior diskectomy fusion (ACDF). Materials Methods In this Health Insurance Portability Accountability Act-compliant study, retrospective chart review was performed 1244...
OBJECTIVE The incidence of leptomeningeal disease (LMD) has increased as treatments for brain metastases (BMs) have improved and patients with metastatic are living longer. Sample sizes individual studies investigating LMD after surgery BMs its risk factors been limited, ranging from 200 to 400 at LMD, which only allows the use conventional biostatistics. Here, authors used machine learning techniques enhance prediction in a cohort surgically treated BMs. METHODS A conditional survival...
Exposure to stressful or traumatic stimuli may alter hypothalamic-pituitary-adrenal (HPA) axis and sympathoadrenal-medullary (SAM) reactivity. This altered reactivity be a component cause of mental illnesses. Dissecting these mechanisms requires tools reliably probe HPA SAM function, particularly the adrenal component, with temporal precision. We previously demonstrated magnetic nanoparticle (MNP) technology remotely trigger hormone release by activating thermally sensitive ion channels....
Abstract Exposure to stress alters hypothalamic-pituitary-adrenal (HPA) axis reactivity; however, it is unclear exactly how or where within the HPA pathway these changes occur. Dissecting mechanisms requires tools reliably probe function, particularly adrenal component, with temporal precision. We previously demonstrated magnetic nanoparticle (MNP) technology remotely trigger hormone release by activating thermally sensitive ion channels. Here, we applied magnetothermal stimulation...
In this work, we demonstrate the application of anisotropic magnetite nanodiscs (MNDs) as transducers torque to mechanosensory cells under weak, slowly varying magnetic fields (MFs). These MNDs possess a ground state vortex configuration spins which affords greater colloidal stability due eliminated dipole-dipole interactions characteristic isotropic particles similar size. We first predict magnetization using micromagnetic stimulations in sub-micron and then use electron holography...
In this work, we demonstrate the application of anisotropic magnetite nanodiscs (MNDs) as transducers torque to mechanosensory cells under weak, slowly varying magnetic fields (MFs). These MNDs possess a ground state vortex configuration spins which affords greater colloidal stability due eliminated dipole-dipole interactions characteristic isotropic particles similar size. We first predict magnetization using micromagnetic stimulations in sub-micron and then use electron holography...
In this work, we demonstrate the application of anisotropic magnetite nanodiscs (MNDs) as transducers torque to mechanosensory cells under weak, slowly varying magnetic fields (MFs). These MNDs possess a ground state vortex configuration spins which affords greater colloidal stability due eliminated dipole-dipole interactions characteristic isotropic particles similar size. We first predict magnetization using micromagnetic stimulations in sub-micron and then use electron holography...
In this work, we demonstrate the application of anisotropic magnetite nanodiscs (MNDs) as transducers torque to mechanosensory cells under weak, slowly varying magnetic fields (MFs). These MNDs possess a ground state vortex configuration spins which affords greater colloidal stability due eliminated dipole-dipole interactions characteristic isotropic particles similar size. We first predict magnetization using micromagnetic stimulations in sub-micron and then use electron holography...