Carlos Castillo-Rangel

ORCID: 0000-0003-2956-5112
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About
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Research Areas
  • Vascular Malformations Diagnosis and Treatment
  • Intracranial Aneurysms: Treatment and Complications
  • Meningioma and schwannoma management
  • Neurofibromatosis and Schwannoma Cases
  • Spine and Intervertebral Disc Pathology
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Head and Neck Surgical Oncology
  • Glioma Diagnosis and Treatment
  • Spinal Fractures and Fixation Techniques
  • Cerebrovascular and Carotid Artery Diseases
  • Parkinson's Disease Mechanisms and Treatments
  • Facial Nerve Paralysis Treatment and Research
  • Pituitary Gland Disorders and Treatments
  • Trigeminal Neuralgia and Treatments
  • Neurosurgical Procedures and Complications
  • Neurological disorders and treatments
  • COVID-19 and healthcare impacts
  • Botulinum Toxin and Related Neurological Disorders
  • Bone Tumor Diagnosis and Treatments
  • Spinal Hematomas and Complications
  • Cervical and Thoracic Myelopathy
  • Scientific Research and Technology
  • Reconstructive Surgery and Microvascular Techniques
  • Spinal Dysraphism and Malformations
  • Vascular Malformations and Hemangiomas

Institute for Social Security and Services for State Workers
2014-2025

Princess Máxima Center
2025

Instituto Politécnico Nacional
2024-2025

Institute of Clinical Research
2025

Universidad Autónoma de Santo Domingo
2025

National Research Mordovia State University
2025

Hospital General de México
2025

Instituto de Neurologia Y Neurocirugia
2024

University Medical Center Utrecht
2024

Utrecht University
2024

Background: The trunk of the basilar artery has not been included in microanatomy studies. Anatomical variants perforant branches vertebrobasilar and their relationship with neural structures are very important surgical approaches. Surgical dissection for treatment vascular lesions requires a perfect knowledge microsurgical anatomy. Methods: We conducted descriptive analysis 50 brains, which were fixed formalin at 10% 2 weeks, arterial system was injected colored latex. After dissection, it...

10.3390/diagnostics14050534 article EN cc-by Diagnostics 2024-03-02

In 1986, surveillance of acute flaccid paralysis (AFP) cases among children <15 years age was implemented in Latin America as part the initiative to eradicate poliomyelitis from Western Hemisphere. Data on AFP, including Guillain-Barré syndrome (GBS), could be analyzed a regional registry system and specific GBS studies seven countries. Between 1989 1991, 3112 were reported America, representing 52% all nonpolio AFP cases. From countries, total 1527 (49%) studied, an overall annual incidence...

10.1093/infdis/175.supplement_1.s160 article EN The Journal of Infectious Diseases 1997-02-01

Deep brain stimulation (DBS) is a surgical procedure used to treat various neurological pathologies, being its greatest use in movement disorders. The FDA first approved deep 1997 essential tremor, 2002 it was for Parkinson's disease, 2003 dystonia and 2009 obsessive compulsive disorder. However, until recently this technique began be implemented the treatment of other diseases. To conduct research on different diseases where articles were chosen from Pubmed, Google Scholar, Redalyc Scielo...

10.1016/j.neurop.2022.03.001 article EN cc-by Neurology Perspectives 2022-03-26

Lumbar foraminal stenosis (LFS) occurs primarily due to degenerative changes in older adults, affecting the spinal foramina and leading nerve compression. Characterized by pain, numbness, muscle weakness, LFS arises from structural discs, joints, ligaments, further complicated factors like inflammation spondylolisthesis. Diagnosis combines patient history, physical examination, imaging, while management ranges conservative treatment surgical intervention, underscoring need for a tailored approach.

10.3390/medsci12030034 article EN cc-by Medical Sciences 2024-07-22

<title>Abstract</title> <italic>Introduction</italic>: Intracranial dermoid cysts are rare, benign tumors, making up 0.04–0.6% of brain tumors and originating from ectodermal cells, unlike more complex teratomas pluripotent germ cells. Dermoid cysts, containing only derivatives, differ epidermoid by lacking dermal appendages. They commonly cause symptoms like seizures headaches, with specific types associated their rupture or chronic presence, impacting nearby structures. <italic>Material...

10.21203/rs.3.rs-5685800/v1 preprint EN cc-by Research Square (Research Square) 2025-01-06

Ventriculoperitoneal (VP) shunting is commonly used to treat hydrocephalus, especially in pediatric patients. Despite its effectiveness, rare complications, like the migration of distal catheter into pulmonary trunk (PT), can occur. This case study presents a 17-year-old boy who experienced this complication, highlighting diagnostic challenges, surgical intervention, and outcomes. A review literature emphasizes rarity clinical management such cases. retrospective was conducted on patient...

10.7759/cureus.77088 article EN Cureus 2025-01-07

Glioblastoma (GBM) characterized byits rapid progression and challenging prognosis, often featuring mutations in the Kirsten rat sarcoma virus (KRAS) gene, which is crucial for numerous cellular signaling mechanisms. Emerging research underscores a significant interaction between KRAS microRNAs (miRNAs) these cancers, with miRNAs playing key roles as both regulators mediators within framework. The concept of oncogene-induced senescence (OIS) explored protective mechanism against tumor...

10.2174/0109298673343892241207034138 article EN Current Medicinal Chemistry 2025-01-03

Breast cancer is the leading cause of cancer-related death in Mexico, with high mortality associated spinal bone metastasis. We propose to standardize a murine model metastasis study and understand tumor microenvironment. An experimental, prospective, longitudinal was conducted using 18 CD1/Nu/Nu 30g nude mice. Two cell lines, MCF-7 4T1, were inoculated, clinical follow-up performed, biopsy samples obtained for histopathological evaluation. Histopathological evaluation models inoculated line...

10.7759/cureus.77291 article EN Cureus 2025-01-11

Meningiomas are the most common primary central nervous system tumors, often requiring surgical resection. Presurgical embolization (PSE) is used to reduce intraoperative bleeding, although its effectiveness varies. This study evaluates safety and efficacy of PSE using ethyl-vinyl alcohol (EVOH) in meningioma surgeries. included 48 patients with intracranial meningiomas treated between January 2022 August 2024. Patients were divided into two groups: Group A (n=24) underwent surgery without...

10.1016/j.wneu.2025.123663 article EN cc-by World Neurosurgery 2025-01-30

Optic nerve sheath hemangiomas (ONSHs) are rare vascular tumors from the blood vessels surrounding optic nerve, accounting for <1% of and 0.5% malformations. Although benign, their location near poses a risk significant damage vision loss. Symptoms often include visual disturbances, eye pain, strabismus, making it difficult to make diagnosis. Advances in imaging, especially magnetic resonance imaging (MRI), have improved early detection In addition, insights into molecular mechanisms,...

10.25259/sni_979_2024 article EN cc-by-nc-sa Surgical Neurology International 2025-02-07

Background and objective The complexities of spinal surgery, particularly the intricacies cervical pathology, demand precision expertise in surgical interventions. Cervical laminoplasty is a procedure that requires meticulous execution profound understanding delicate anatomical structures. Recognizing limitations traditional training methods, this study highlights transformative impact integrating 3D modeling printing technologies into medical education. These provide an immersive,...

10.7759/cureus.79021 article EN Cureus 2025-02-14

This report presents a case of craniovertebral junction (CVJ) trauma caused by gunshot injury, managed successfully with endoscopic transoral odontoidectomy. The procedure achieved ventral decompression, bullet extraction, and neurological improvement while addressing challenges like severe edema, fragmented dental structures, cerebrospinal fluid (CSF) leaks using advanced tools expert planning. A patient wound to the CVJ underwent Preoperative imaging revealed near vital prompting surgery...

10.7759/cureus.80421 article EN Cureus 2025-03-11

Background The persistent trigeminal artery (PTA) is a rare embryonic connection between the internal carotid and basilar arteries. While typically regressing during development, it remains in some individuals, potentially leading to clinical concerns such as cerebrovascular complications or cranial nerve compression. A clear understanding of PTA anatomy essential for neurosurgical planning intervention, its presence can affect blood flow dynamics influence surgical strategies. Methods This...

10.25259/sni_1084_2024 article EN cc-by-nc-sa Surgical Neurology International 2025-03-28

The azygos anterior cerebral artery (ACA) is an uncommon anatomical variation with important clinical implications. This study presents in-depth morphometric analysis of a single brain specimen displaying this variant. goal to improve the understanding its characteristics and influence on vascular health. Through precise dissection measurement, highlights structural features ACA potential role in conditions, particularly relation aneurysm formation associated risks. was sourced from...

10.7759/cureus.83063 article EN Cureus 2025-04-27

BACKGROUND AND OBJECTIVES: The greater occipital nerve (GON) and lesser (LON) have gained importance because of conditions such as neuralgia cervicogenic headaches. To a great depth, their anatomy is essential for performing viable diagnostic therapeutic procedures blocks decompression procedures. This research involves identifying key anatomic landmarks the potential compression points GON LON using cadaveric dissections possible surgical approaches. METHODS: Five fresh, untreated cadavers,...

10.1227/ons.0000000000001598 article EN Operative Neurosurgery 2025-04-29

Background The recurrent artery of Heubner (RAH) was first described by Johann in 1872 and later named H.F. Aitken 1909. It is the largest medial lenticulostriate from anterior cerebral (ACA). Originating A1, A2, or ACA-anterior communicating junction, it supplies key brain structures like caudate nucleus hypothalamus, with variations origin course among individuals. Methods We studied 15 human brains (5 females 10 males), ensuring no neurological disease damage to complexes. Brains were...

10.25259/sni_81_2025 article EN Surgical Neurology International 2025-05-02

<title>Abstract</title> Background Clinical observations suggest relative preservation of endocrine function following midline incisions during transsphenoidal pituitary surgery despite the gland's rich vascularity. This study investigated intrapituitary microvascular architecture to identify a potential anatomical correlate for this functional resilience. Methods descriptive observational utilized three human cadaveric glands. Histological sections were prepared in sagittal and coronal...

10.21203/rs.3.rs-6552108/v1 preprint EN Research Square (Research Square) 2025-05-07

OBJECTIVE The aim of the study was to observe intraluminal characteristics flow diverter devices and neurovascular stents immediately after placement using optical coherence tomography (OCT), with a focus on presence intrastent thrombosis device apposition vascular wall. Additionally, authors describe postimplantation evolution, particularly remodeling (neoendothelialization), aneurysm closure, patency side branches. METHODS Intravascular OCT evaluations were performed 9 different times in 5...

10.3171/2025.1.jns242458 article EN Journal of neurosurgery 2025-05-01

Background: The internal carotid artery (ICA) has multiple classification systems; it is essential for brain blood supply, which bone/neurovascular relationships of wide neurosurgical interest; its anatomy must be known in detail, angiographic-imaging aspect (endovascular), ventral (endoscopic endonasal approaches); and lateral (anterolateral skull base surgery). Our objectives were to identify coincidences/differences between the main classifications ICA improve surgical-anatomical...

10.25259/sni_27_2025 article EN Surgical Neurology International 2025-05-16

Stathmin-2 (also known as SCG10 ) is encoded by the STMN2 gene, whose mRNA one of most abundantly expressed in human motor neurons. In almost all instances ALS and other TDP-43 proteinopathies, stathmin-2 encoding mRNAs are cryptically spliced polyadenylated neurons, a pathogenic consequence nuclear loss function RNA binding protein TDP-43. While has been shown to enhance regeneration after axonal injury axons cultured here, we show that crush within adult murine nervous system wild-type or...

10.1073/pnas.2502294122 article EN cc-by-nc-nd Proceedings of the National Academy of Sciences 2025-05-20
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