A5075198546- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthetic Organic Chemistry Methods
- Luminescence and Fluorescent Materials
- Crystallography and molecular interactions
- Asymmetric Synthesis and Catalysis
- Molecular Sensors and Ion Detection
- Marine Sponges and Natural Products
- Synthesis and Properties of Aromatic Compounds
- Advanced biosensing and bioanalysis techniques
- Porphyrin and Phthalocyanine Chemistry
- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Chemical synthesis and alkaloids
- Spectroscopy and Quantum Chemical Studies
- Nanocluster Synthesis and Applications
- Synthesis and biological activity
- Synthesis of heterocyclic compounds
- Sulfur-Based Synthesis Techniques
- Supramolecular Chemistry and Complexes
- Chemical Synthesis and Reactions
- Nanopore and Nanochannel Transport Studies
- Advanced Synthetic Organic Chemistry
- Photoreceptor and optogenetics research
- Organoboron and organosilicon chemistry
University of Geneva
2016-2021
Charles Humbert 8
2018-2021
Centre National de la Recherche Scientifique
2012-2016
University of Glasgow
2016
Université Paris Sciences et Lettres
2014-2016
ESPCI Paris
2014-2016
Laboratoire de Chimie Organique
2014-2016
ParisTech
2014-2015
Université de Rennes
2015
Institut des Sciences Chimiques de Rennes
2015
A series of chiral fluorescent macrocycles display a remarkable combination both +/– ECD and strong on/off CPL reversible switching upon cation binding displacement.
The first observation of circular polarization electrochemiluminescence (ECL) from a purely organic derivative is reported. A bispyrene scaffold mounted on constrained polyether macrocycle displaying intense excimer fluorescence and highly circularly-polarized (CP) photoluminescence has been selected for this purpose. compound displays an ECL dissymmetry factor about |8×10-3 |, which in good agreement with the corresponding value. This step towards molecular engineering tailored dyes that...
We study the behavior of multicomponent giant unilamellar vesicles (GUVs) in presence AzoTAB, a photosensitive surfactant. GUVs are made an equimolar ratio dioleoylphosphatidylcholine (DOPC) and dipalmitoylphosphatidylcholine (DPPC) various amounts cholesterol (Chol), where lipid membrane shows phase separation into DPPC-rich liquid-ordered (Lo) DOPC-rich liquid-disordered (Ld) phase. find that UV illumination at 365 nm for 1 s induces bursting significant fraction GUV population. The...
Varying the structure of perylene-based dimers allows tuning excited state from an excimer to a charge-separated state.
Abstract The first observation of circular polarization electrochemiluminescence (ECL) from a purely organic derivative is reported. A bispyrene scaffold mounted on constrained polyether macrocycle displaying intense excimer fluorescence and highly circularly‐polarized (CP) photoluminescence has been selected for this purpose. compound displays an ECL dissymmetry factor about |8×10 −3 |, which in good agreement with the corresponding value. This step towards molecular engineering tailored...
The total synthesis of (+)-cryptocaryol A was achieved in 20 steps from (R)-glycidol. key were a Prins cyclization/reductive cleavage sequence to construct the C5-C11 polyol fragment, diastereoselective aldol reaction control stereogenic center at C13, and stereocontrolled reduction introduce C15.
The synthesis of the carbon skeleton filipin III, a polyenic macrolactone possessing 11 stereogenic centers, was achieved using convergent strategy with longest linear sequence 19 steps starting from hexanal. Construction polyene realized two successive Heck couplings as key steps. Control centers polyol fragment performed by utilizing an Evans aldolization, 1,3-syn enantio- and diastereoselective allylations, hemiacetalization/oxa-Michael sequence, reduction. fragments were coupled 1,5-anti...
We here disclosed a new protocol for the condensation of acetophenone derivatives and active methylene compounds with aldehydes in presence boric acid under microwave conditions. Implementation reaction is simple, healthy environmentally friendly owing to use non-toxic catalyst coupled solvent-free procedure. A large variety known or novel have thus been prepared, including substrates bearing base-sensitive functional groups.
A series of bis(pyreneamide) macrocycles, synthesized in two steps from THF, THP, oxepane and 1,4‐dioxane, are tested as chemosensors for a large range mono‐, di‐ trivalent cations. In their native states, these macrocycles exhibit strong excimer fluorescence that is quenched upon the addition metal ions (alkaline, alkaline earth, p ‐, d‐, f ‐block metals). UV‐Vis spectrophotometric titrations, cyclic voltammetry, quenching, transient absorption spectroscopy experiments helped characterize...
A highly diastereoselective synthesis of trifluoromethylated 1,3-dioxanes is described. The reaction proceeds by an addition/oxa-Michael sequence and works efficiently under mild conditions, with a good substrate scope acceptable to yields.
Stereocontrolled access to all the diastereomers of 1,3,5,7-tetraol structural units was developed using a Prins cyclisation–reductive cleavage sequence.
Abstract The synthesis of spirocyclic amide acetals (33–93 %) has been achieved through Ru(II)‐catalyzed condensations N ‐carbamate protected pyrrolidinones with metal carbenes derived from α‐diazo‐β‐ketoesters. Thanks to the mildness diazo decomposition conditions induced by a 1 : combination [CpRu(MeCN) 3 ][BAr F ] and 1,10‐phenanthroline, formation sensitive products is possible. Full characterization this carbonyl‐ylide mediated process provided DFT calculations.
Double hydrothiolation of bis enol ether macrocycles was achieved under photo-mediated conditions. The thiol-ene reactions afford a fully regioselective anti-Markovnikov post-functionalization. Thanks to the use ethanedithiol as reagent, moderate excellent diastereoselectivity accomplished leading containing four defined stereocenters in only three steps from 1,4-dioxane, tetrahydrofuran (THF) or tetrahydropyran (THP).
Recently, significant research activity has been devoted to thiolate-protected gold clusters due their attractive optical and electronic properties. These properties as well solubility stability can be controlled by post-synthetic modification strategies. Herein, the ligand exchange reaction between Au25(2-PET)18 cluster (where 2-PET is 2-phenylethanethiol) di-thiolated crown ether (t-CE) ligands bearing two chromophores was studied. The post-functionalization aimed endow with ion binding...
Doubly bridged biphenyl azocines can be prepared in a single step through copper-catalyzed reactions of doubly azepine and diazodiester reagents. Double [1,2]-Stevens rearrangements occur at 100 °C to afford tethered eight-membered rings (49 61%) as trans cis regioisomers (1:1 ratio). These products present an axial chirality. ECD VCD analyses the separated enantiomers (CSP-HPLC) were used assign absolute configuration. High configurational stability is observed for both racemization does...
Abstract The new method presented here provides access to all the possible diastereomers.