A5090577074- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Cancer Treatment and Pharmacology
- RNA Research and Splicing
- MXene and MAX Phase Materials
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Cancer Research and Treatments
- Advanced Breast Cancer Therapies
- Anorectal Disease Treatments and Outcomes
- Microtubule and mitosis dynamics
- Colorectal and Anal Carcinomas
Sixth Affiliated Hospital of Sun Yat-sen University
2019-2025
Sun Yat-sen University
2019-2025
Jilin Normal University
2023-2024
Weihai Science and Technology Bureau
2018
Abstract Dysregulation of the cell cycle machinery leads to genomic instability and is a hallmark cancer associated with chemoresistance poor prognosis in colorectal (CRC). Identifying targeting aberrant expected improve current therapies for CRC patients. Here,upregulated polo‐like kinase 1 (PLK1) signaling, accompanied by deregulation cycle‐related pathways identified. It shown that PLK1 signaling correlates recurrence Genetic pharmacological blockade significantly increases sensitivity...
Resistance to neoadjuvant chemotherapy leads poor prognosis of locally advanced rectal cancer (LARC), representing an unmet clinical need that demands further exploration therapeutic strategies improve outcomes. Here, we identified a noncanonical role RB1 for modulating chromatin activity contributes oxaliplatin resistance in colorectal (CRC). We demonstrate induces phosphorylation, which is associated with the oxaliplatin-based LARC. Inhibition phosphorylation by CDK4/6 inhibitor results...
Prevalent copy number alteration is the most prominent genetic characteristic associated with ovarian cancer (OV) development, but its role in immune evasion has not been fully elucidated. In this study, we identified RAD21, a key component of cohesin complex, as frequently amplified oncogene that could modulate response OV. Through interrogating RAD21-regulated transcriptional program, found RAD21 directly interacts YAP/TEAD4 corepressors and recruits NuRD complex to suppress interferon...
Abstract Background Enhancer of zeste homolog 2 (EZH2), the key catalytic subunit polycomb repressive complex (PRC2), is overexpressed and plays an oncogenic role in various cancers through catalysis-dependent or catalysis-independent pathways. However, related mechanisms contributing to ovarian cancer (OC) are not well understood. Methods The levels EZH2 H3K27me3 were evaluated 105 OC patients by immunohistochemistry (IHC) staining, these stratified based on levels. Canonical noncanonical...
Cancer-associated fibroblasts (CAFs) in the tumour microenvironment are associated with poor prognosis and chemoresistance multiple solid tumours. However, there is a lack of universal measures CAFs colorectal cancer (CRC). The aim this study was to assess utility fibroblast-related gene signature (FRGS) for predicting patient outcomes reveal its relevant mechanism. GSE39582 dataset, which includes 316 CRC patients who did not receive adjuvant chemotherapy used as discovery cohort identify...
Abstract Poly (ADP‐ribose) Polymerase inhibitors (PARPi) have demonstrated remarkable clinical efficacy in treating ovarian cancer (OV) with BRCA1/2 mutations. However, drug resistance inevitably limits their applications and there is an urgent need for improved therapeutic strategies to enhance the utility of PARPi, such as Olaparib. Here, compelling evidence indicates that sensitivity PARPi associated cell cycle dysfunction. Through high‐throughput screening a kinase inhibitor library,...
XPO1 is an attractive and promising therapeutic target frequently overexpressed in multiple hematological malignancies. The clinical use of inhibitors natural killer/T-cell lymphoma (NKTL) not well documented. Here, we demonstrated that overexpression indicator poor prognosis patients with NKTL. compassionate the inhibitor selinexor combination chemotherapy showed favorable outcomes three refractory/relapsed (R/R) NKTL patients. Selinexor induced complete tumor regression prolonged survival...
The hypoxic tumor microenvironment accelerates the invasion and migration of colorectal cancer (CRC) cells. aim this study was to develop validate a hypoxia gene signature for predicting outcome in stage I/II CRC patients that have limited therapeutic options.The (HGS) constructed using transcriptomic data 309 with complete clinical information from CIT microarray dataset. A total 1877 prognostic six independent datasets were divided into training cohort two validation cohorts. Univariate...
Ovarian cancer is characterized by aberrant activation of the mitogen-activated protein kinase (MAPK), highlighting importance targeting MAPK pathway as an attractive therapeutic strategy. However, clinical efficacy MEK inhibitors limited intrinsic or acquired drug resistance. Here, we established patient-derived ovarian models resistant to and demonstrated that resistance clinically approved inhibitor trametinib was associated with enhancer reprogramming. We also showed decommissioning...
In colorectal cancer (CRC), KRAS mutations enhance metachronous metastasis, a condition without prognostic biomarkers or preventive measures. The present study demonstrated that mutation may be risk factor for CRC metastasis through meta‑analysis of public databases. A scoring model was constructed using machine learning predicting in KRAS‑mutant CRC. Wound healing and Transwell assay indicated inhibitors strongly suppress migration invasion capabilities high‑risk cells these findings were...
The benefit of transanal total mesorectal excision (TaTME) for mid and low rectal cancer is conflicting.To assess compare the short-term outcomes TaTME with conventional laparoscopic (LaTME) middle cancer.We searched PubMed, Embase Cochrane Library databases studies addressing versus LaTME between 2008 December 2018. Randomized controlled trials (RCTs) retrospective which compared were included.Twelve case-control identified, including a 899 patients. We did not find significant differences...
Abstract Immunotherapy has dramatically changed the landscape of treatment for colorectal cancer (CRC), but currently lack effective predictive biomarker, especially tumors with mismatch repair (MMR) proficiency. The response immunotherapy is associated cell–cell interactions in tumor microenvironment, encompassing processes such as recognition, binding, and adhesion. However, function immunoglobulin superfamily (IGSF) genes immune microenvironment remains uncharacterized. This study...
Treatment for osteonecrosis of the femoral head (ONFH) in young individuals remains controversial. We developed a lantern-shaped screw, which was designed to provide mechanical support prevent its collapse, treatment ONFH. The purpose this study investigate efficacy and safety screw loaded with autologous bone pre-collapse stages ONFH.Thirty-two patients were randomly divided into two groups: group (core decompression autogenous bone) control graft). During 36 months follow-up after surgery,...
Colorectal cancer (CRC) with KRAS mutation is prone to develop metachronous metastasis. However, effective measures for prediction and prevention of such clinical issue are currently unavailable. In this study, we confirmed that a risk factor CRC metastasis through meta-analysis public database analysis. Based on the ICGC-AGRO database, have constructed scoring model predicting in KRAS-mutant using machine learning, which was validated datasets. Furthermore, discovered inhibitors can...
The ecological diversity in the tumor microenvironment influences cancer progression and clinical outcomes of patients. However, complexity cellular tissue components hamper quantitative dissection microenvironment. In this study, we aimed to develop an efficient robust artificial intelligence (AI)-empowered framework for identification prognostic spatial organization features based on histopathological images. Using two public H&E image cohorts involving 107,180 hand-delineated patches,...
Inhibitor of β-catenin and T-cell factor (ICAT) was first found as a polypeptide that blocks β-catenin–TCF interaction. Abundant evidence has shown ICAT different functions in diverse cancers’ progression. Nevertheless, the roles it plays colorectal cancer (CRC) have not been described. Here, we documented expression higher CRC tissue than adjacent normal prognosis better high-ICAT patients. The overexpression inhibited cell proliferation both vitro vivo. Wnt pathway transcriptional activity...