A5033446152- Fungal and yeast genetics research
- Evolution and Genetic Dynamics
- Genetic Mapping and Diversity in Plants and Animals
- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- ATP Synthase and ATPases Research
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- Plant nutrient uptake and metabolism
- Plant biochemistry and biosynthesis
- Plant Disease Resistance and Genetics
- Metalloenzymes and iron-sulfur proteins
- Genomics and Phylogenetic Studies
- Mitochondrial Function and Pathology
- Genomics and Chromatin Dynamics
- Fermentation and Sensory Analysis
Princeton University
2007-2017
Howard Hughes Medical Institute
2007
Massachusetts Institute of Technology
2007
Center for Cancer Research
2007
Aneuploidy is a condition frequently found in tumor cells, but its effect on cellular physiology not known. We have characterized one aspect of aneuploidy: the gain extra chromosomes. created collection haploid yeast strains that each bear an copy or more almost all Their characterization revealed aneuploid share number phenotypes, including defects cell cycle progression, increased glucose uptake, and sensitivity to conditions interfering with protein synthesis folding. These phenotypes...
The experimental evolution of laboratory populations microbes provides an opportunity to observe the evolutionary dynamics adaptation in real time. Until very recently, however, such studies have been limited by our inability systematically find mutations evolved organisms. We overcome this limitation using a variety DNA microarray-based techniques characterize genetic changes—including point mutations, structural changes, and insertion variation—that resulted from 24 haploid diploid...
Hybridization is often considered maladaptive, but sometimes hybrids can invade new ecological niches and adapt to novel or stressful environments better than their parents. The genomic changes that occur following hybridization facilitate genome resolution and/or adaptation are not well understood. Here, we examine hybrid evolution using experimental of de novo interspecific yeast Saccharomyces cerevisiae × uvarum parentals. We evolved these strains in nutrient-limited conditions for...
Evolutionary outcomes depend not only on the selective forces acting upon a species, but also genetic background. However, large timescales and uncertain historical selection pressures can make it difficult to discern such important background differences between species. Experimental evolution is one tool compare evolutionary potential of known genotypes in controlled environment. Here we utilized highly reproducible adaptation Saccharomyces cerevisiae investigate whether experimental other...
It has been more than two decades since the original chromosome transmission fidelity (Ctf) screen of Saccharomyces cerevisiae was published. Since that time spectrum mutations known to cause Ctf and, generally, instability (CIN) expanded dramatically as a result systematic screens across yeast mutant arrays. Here we describe comprehensive summary genetic and cloning remaining complementation groups efforts expand our knowledge CIN gene repertoire its mutability in model eukaryote. At...
ABSTRACT Hybridization is often considered maladaptive, but sometimes hybrids can invade new ecological niches and adapt to novel or stressful environments better than their parents. However, the genomic changes that occur following hybridization facilitate genome resolution and/or adaptation are not well understood. Here, we address these questions using experimental evolution of de novo interspecific hybrid yeast Saccharomyces cerevisiae x uvarum parentals. We evolved strains in nutrient...
Abstract Evolutionary outcomes depend not only on the selective forces acting upon a species, but also genetic background. However, large timescales and uncertain historical selection pressures can make it difficult to discern such important background differences between species. Experimental evolution is one tool compare evolutionary potential of known genotypes in controlled environment. Here we utilized highly reproducible adaptation Saccharomyces cerevisiae investigate whether other...