A5011562240- Microbial Metabolic Engineering and Bioproduction
- Biofuel production and bioconversion
- Enzyme Production and Characterization
- Fermentation and Sensory Analysis
- Fungal and yeast genetics research
- Bioinformatics and Genomic Networks
- Microbial Metabolites in Food Biotechnology
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Pulmonary Hypertension Research and Treatments
- Magnetic and Electromagnetic Effects
- Circular RNAs in diseases
- Protein Hydrolysis and Bioactive Peptides
- Plant nutrient uptake and metabolism
- MicroRNA in disease regulation
- Aortic Disease and Treatment Approaches
- SARS-CoV-2 and COVID-19 Research
- Enzyme Structure and Function
- Aortic aneurysm repair treatments
- Polysaccharides Composition and Applications
- Phytase and its Applications
- Food composition and properties
- Polysaccharides and Plant Cell Walls
- Studies on Chitinases and Chitosanases
Marmara University
2018-2024
Synthetic Biologics (United States)
2018
Kookmin University
2018
University of Cambridge
2018
Boğaziçi University
2009-2015
Orient-Institut Istanbul
2015
The integrative analysis of transcriptome, regulatory transcriptional network and ethanol tolerance revealed biological processes affected by in<italic>Saccharomyces cerevisiae</italic>.
Abstract The current trend in industrial biotechnology is to move from batch or fed‐batch fermentations continuous operations. success of this transition will require the development genetically stable production strains, use strong constitutive promoters, and new medium formulations that allow an appropriate balance between cell growth product formation. We identified genes showed high expression Komagataella phaffii during different steady‐state conditions explored utility promoters these...
Saccharomyces cerevisiae has been widely used for bio-ethanol production and development of rational genetic engineering strategies leading both to the improvement productivity ethanol tolerance is very important cost-effective production. Studies on identification genes that are up- or down-regulated in presence indicated may be involved protect cells against stress, but not necessarily required tolerance.In present study, a novel network based approach was developed identify candidate...
Ovarian cancer is the second most common gynecologic and remains leading cause of death all oncologic disease. Therefore, understanding molecular mechanisms underlying disease, identification effective predictive biomarkers are invaluable for development diagnostic treatment strategies. In present study, a differential co-expression network analysis was performed via meta-analysis three transcriptome datasets serous ovarian adenocarcinoma to identify novel candidate biomarker signatures,...
Parageobacillus thermantarcticus strain M1 is a Gram-positive, motile, facultative anaerobic, spore forming, and thermophilic bacterium, isolated from geothermal soil of the crater Mount Melbourne (74°22′ S, 164°40′ E) during Italian Antarctic Expedition occurred in Austral summer 1986–1987. Strain demonstrated great biotechnological industrial potential owing to its ability produce exopolysaccharides (EPSs), ethanol thermostable extracellular enzymes, such as an xylanase β-xylosidase,...
Idiopathic pulmonary arterial hypertension (IPAH) is a progressive disease that affects the arteries, resulting in increased vascular resistance and right ventricular dysfunction, which can ultimately lead to heart failure death. The molecular substrates of IPAH are poorly understood while diagnostics therapeutics innovation remain as unmet needs for this debilitating disease. In study, network-based methodology was used uncover salient mechanisms inform drug diagnostic discovery,...
Cardiovascular disease (CVD) is the leading cause of death among adults in developed countries. Among CVDs, abdominal aortic aneurysm (AAA) and occlusive (AOD) are great public health importance because high mortality rate elderly population. Despite significant molecular insights into AAA AOD, mechanisms these diseases remain unclear, current lack robust diagnostic prognostic biomarkers requires novel approaches to biomarker discovery targeting. In this study, we performed a comparative...
Lung adenocarcinoma (LUAD) is a significant planetary health challenge with its high morbidity and mortality rate, not to mention the marked interindividual variability in treatment outcomes side effects. There an urgent need for robust systems biomarkers that can help early cancer diagnosis, prediction of outcomes, design precision/personalized medicines LUAD. The present study aimed at LUAD deployed integrative bioinformatics machine learning tools harness gene expression data. Predictive...
This study investigates the global transcriptional response of Saccharomyces cerevisiae strain WTPB-G, which was developed by transforming laboratory FY23 with pPB-G plasmid expressing Bacillus subtilis α-amylase and Aspergillus awamori glucoamylase as a fusion protein. Genome-wide analysis transcript levels revealed cellular mechanisms related pathways that were affected genetic modification, conferred ability starch utilization to wild-type cells introduction plasmid-harboring gene...
Lung cancer is one of the most occurring and death-causing cancers worldwide. Despite progress, survival rate still low due to late diagnosis. The aim this study develop a computational framework identify potential prognostic biomarkers for lung adenocarcinoma (LUAD). Gene expression profiles obtained from three independent studies were analyzed find differentially expressed genes (DEGs) in LUAD. Disease-specific protein-protein interaction (PPI) network was constructed among common DEGs hub...
Please scan the above QR code with your smartphone to take you B&B Video Highlights page: summaries of recently published articles created by articles' authors. Cover LegendThe membrane-anchored monomeric subunit polypeptides can be drifted and auto-assembled into functional homo-or heterodimeric proteins on bacterial inner membrane.This cover image illustrates spheroplasts displaying homodimeric Fc regions using a novel display system, membrane protein drift assembly (MPDA) for effi cient...