Colorectal cancer (CRC) is a common digestive tract tumor, with incidences continuing to rise. Although modern medicine has extended the survival time of CRC patients, its adverse effects and financial burden cannot be ignored. multi-step process can caused by disturbance gut microbiome chronic inflammation's stimulation. Additionally, presence precancerous lesions also risk factor for CRC. Consequently, scientists are increasingly interested in identifying multi-target, safe, economical...

Ginkgo biloba is a typical relic plant that rarely suffers from pest hazards. This study analyzed the pattern of G. hazards in Beijing; tested antifeedant activity extracts, including ginkgo flavonoids, ginkgolide, and bilobalide, against Hyphantria cunea larvae; determined activities glutathione transferase (GSTs), acetylcholinesterase (AChE), carboxylesterase (CarE) mixed-functional oxidase (MFO), larvae after feeding on these secondary metabolites; screened for effective botanical...

Lymph nodes metastasis (LNM) and distant (DM) are important prognostic factors in colorectal cancer (CRC) determine the following treatment approaches. We aimed to find clinicopathological associated with LNM DM, analyze prognosis of CRC patients T1 stage.A total 17 516 eligible were retrospectively enrolled study based on Surveillance, Epidemiology, End Results (SEER) database during 2004-2016. Logistic regression analysis was performed identify risk for DM. Unadjusted adjusted Cox...

Background: Non-cancer causes of death in patients with colorectal cancer (CRC) have not received much attention until now. The purpose the current study is to investigate non-cancer CRC at different periods latency. Methods: Eligible were included from Surveillance, Epidemiology, and End Results (SEER) database, standardized mortality ratios (SMRs) calculated using SEER*Stat software 8.3.8. Results: A total 475,771 included, whom 230,841 died during follow-up period. Within 5 years, was...

Energy storage has been a crucial component in human energy utilization, with the compressed air system (CAES) emerging as significant and indispensable aspect of conversation around solutions. Historically, understanding CAES was confined to theoretical models, but recent years have witnessed an increase practical applications constructions, bringing technology into public eye. These developments yielded valuable precise data that researchers can leverage. Utilizing these points, this paper...

The Asian longhorned beetle, Anoplophora glabripennis (Motschulsky) (Coleoptera: Cerambycidae), is distributed widely in China, where it causes severe damage to forests, and a quarantine pest Europe, the United States, Canada. A. overwinters as dormant larvae avoid adverse environmental conditions. To elucidate cold hardiness of larvae, supercooling point (SCP), freezing (FP), hardiness-related compounds were examined overwintering larva from five populations China (Yili, Yanchi,...

The prevalence of gastrointestinal tumors continues to be significant. To uncover promising therapeutic targets for these tumors, we rigorously executed a Mendelian randomization (MR) study comprehensively screen the blood metabolomes potential causal mediators five frequently encountered (Liver Cancer, Colorectal Esophageal Gastric Cancer and Pancreatic Cancer).

Background: According to the 2022 Global Cancer Statistics, lung cancer is leading cause of cancer-related mortality worldwide. Lung adenocarcinoma (LUAD), which a histological subtype Non- Small Cell (NSCLC), accounts for 40% primary cancer. Therefore, there an urgent need identify new prognostic markers as clinical predictive LUAD. Objective: This study aimed investigate role Keratin 80 (KRT80) in prognosis LUAD and its underlying mechanisms. Methods: Bioinformatics analysis was conducted...

Malignant and aggressive, small cell lung cancer (SCLC) constitutes about 15% of all diagnosed cases. With primary therapeutic options such as chemotherapy accompanied by debilitating side effects, interest has been soaring in the competencies herbs. The pharmacological driving force behind beneficial properties Nigella sativa is quinone, thymoquinone (TQ). anti-cancer effects TQ on different cancers have extensively studied. Nonetheless, only one paper entire National Center for...

BACKGROUND:The study was intended to establish predictive nomogram models for predicting total early mortality (the probability of surviving less than or equal 3 months) and cancer-specific in patients with stage IV gastric cancer. This the first prognostic survival MATERIAL AND METHODS:Patients from SEER database were identified using inclusion exclusion criteria. Their clinical characteristics statistically analyzed. The Kaplan-Meier method log-rank test used compare influences different...

Abstract Second primary malignancy (SPM) ranks the second leading cause of death in patients with head and neck cancer (HNC), while studies exploring risk factors for SPM are limited. To clarify this, we investigated relationship between chemotherapy using Surveillance, Epidemiology, End Results (SEER) database. 11 345 initially diagnosed HNC 1998 2016 were selected from SEER First, these divided into two groups according to or not. With Fine Gray model, subdistribution hazard ratio (sHR)...

The traditional Chinese medicines (TCMs) have been used to treat diseases over a long history, but it is still great challenge uncover the underlying mechanisms for their therapeutic effects due complexity of ingredients. Based on novel network pharmacology-based approach, we explored in this study potential targets Liuwei Dihuang (LWDH) decoction its neuroendocrine immunomodulation (NIM) function. We not only collected known compounds LWDH also predicted these using balanced...

Background: Inhalation of asbestos fibers is the most common cause malignant pleural mesothelioma (MPM). In 2004, United States Food and Drug Administration approved a combination cisplatin with pemetrexed to treat unresectable MPM. Nonetheless novel treatment urgently needed. The objective this study report effect dichloroacetate (DCA) or niclosamide (Nic) Nic in Materials methods: DCA was studied using panel MPM cell lines (H28, MSTO-211H, H226, H2052, H2452). Cell viability monitored by...

Background The incidence of colon cancer in young patients is on the rise, which adenocarcinoma most common pathological type. However, a reliable nomogram for early onset (EOCA) to predict prognosis currently lacking. This study aims develop nomograms predicting overall survival (OS) and cancer-specific (CSS) with EOCA. Methods Patients diagnosed EOCA from 2010 2015 were included randomly assigned training set validation set. Cox regression models used evaluate identify independent...

Abstract Background: Malignant and aggressive, small cell lung cancer (SCLC) comprises about 15% of all diagnosed cases. With primary therapeutic options like chemotherapy accompanied by enfeebling side-effects, interest has been soaring in the competencies herbs. One such herb is Nigella sativa . Surviving millennia, originating, populating Middle-eastern Mediterranean culture cuisine, investigated for its anti-cancer effects. The pharmacological driving force behind beneficial properties...