A5027553693- Corporate Finance and Governance
- Fiscal Policy and Economic Growth
- Energy, Environment, Economic Growth
- Banking stability, regulation, efficiency
- Housing Market and Economics
- Corporate Taxation and Avoidance
- Corporate Social Responsibility Reporting
- Labor market dynamics and wage inequality
- Corporate Insolvency and Governance
- HIV Research and Treatment
- Law, Economics, and Judicial Systems
- Cardiac Fibrosis and Remodeling
- Biomedical Text Mining and Ontologies
- Cardiac Ischemia and Reperfusion
- Autophagy in Disease and Therapy
- Taxation and Compliance Studies
- Private Equity and Venture Capital
- Receptor Mechanisms and Signaling
- Credit Risk and Financial Regulations
- Environmental Sustainability in Business
- Sirtuins and Resveratrol in Medicine
- Eicosanoids and Hypertension Pharmacology
- Leech Biology and Applications
- Erythropoietin and Anemia Treatment
- Academic Writing and Publishing
University of Illinois Urbana-Champaign
2016-2025
Mayo Clinic Health System
2023
University of Notre Dame
2017-2020
National Bureau of Economic Research
2020
University of Chicago
2020
John H. Stroger, Jr. Hospital of Cook County
2019
Xiamen University
2016-2018
Henan University of Technology
2013-2015
Fudan University
2014
Baker Heart and Diabetes Institute
2010-2012
Abstract This paper documents evidence that financial constraints increase firms’ toxic emissions given firms actively trade off abatement costs against potential legal liabilities. Exploring three quasi-natural experiments in which resources are likely exogenously affected, we find relaxing reduces U.S. public releases. The effects of on releases amplified when regulatory enforcement and external monitoring weaken. Overall, our highlights the real form environmental pollution, is a costly...
This paper provides novel evidence on the role of pollution in divestitures industrial plants. We find that firms divest pollutive plants following scrutinized environmental risk incidents. Following these divestitures, however, total levels at sold do not decline, and per-employee increase. Furthermore, sellers fully lose access to plants, since they are with supply chain relationships or joint ventures sellers. The sellers, earn higher environmental, social, governance (ESG) ratings,...
ABSTRACT We study the asset market for pollutive plants. Firms divest plants in response to environmental pressures. Buyers are firms facing weaker pressures that have supply chain relationships or joint ventures with sellers. While pollution levels do not decline following divestitures, sellers highlight their sustainable policies subsequent conference calls, earn higher returns as they sell more plants, and benefit from Environmental, Social, Governance (ESG) ratings lower compliance...
BACKGROUND AND PURPOSE While maintaining cardiac performance, chronic β‐adrenoceptor activation eventually exacerbates the progression of remodelling and failure. We examined adverse signalling pathways mediated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase reactive oxygen species (ROS) after β 2 ‐adrenoceptor activation. EXPERIMENTAL APPROACH Mice with transgenic overexpression (β ‐TG) non‐transgenic littermates were either untreated or treated an antioxidant...
This paper examines debt maturity management through early refinancing, where firms retire their outstanding bonds before the due date and simultaneously issue new ones as replacements. Speculative-grade frequently refinance corporate to extend maturity, particularly under accommodating credit supply conditions, leading a procyclical structure. In contrast, investment-grade do not manage in same manner. I exploit protection period of callable show that extension is driven by unobservable...
Abstract Exploiting the random assignment of judges to corporate bankruptcy filings, we estimate financial costs judicial inexperience. Despite new judges’ prior legal experience, formal education, and rigorous hiring process, their public Chapter 11 cases spend 19% more time in bankruptcy, realize 31% higher professional fees, 21% lower creditor recovery rates. Examining possible mechanisms, find that take longer rule on motions assigned these file plans reorganization. Conservative...
Abstract This paper studies tax-minimizing investment, whereby firms tilt capital purchases toward year-end to reduce taxes. We use this pattern characterize how taxes affect investment behavior. exploit variation in firm tax positions from administrative data confirm that minimization causes spikes. Spikes increase when face financial constraints or higher option values of waiting. Cumulative does not completely reverse after develop an model with asymmetries rationalize these patterns....
Esophageal squamous cell carcinoma (ESCC) remains one of the most common malignancies in China and has a high metastasis rate poor prognosis. Cancer-associated fibroblasts (CAFs), prominent component tumor microenvironment, can affect progression metastasis, but underlying mechanism unclear. There are no studies that explore role hydrogen peroxide-inducible clone 5 (HIC-5) ESCC or compare HIC-5 CAFs adjacent noncancerous normal (NFs). In this study, we isolated primary NFs from patients. was...
Exploiting within-firm variations in plant-level toxic releases, we document the effect of managerial hometown attachment on corporate environmental policies. Pollution intensity is 20% lower for plants near CEOs' hometowns, achieved by conducting more costly waste management activities such as source reduction, recycling, and energy recovery. Analyses using CEO turnover events provide causal inference. Hometown emission reduction stronger poorly-governed firms, significantly weakened...
We exploit within-firm variations in plant-level toxic releases to examine the effect of managerial hometown preference on corporate environmental policies. find that pollution levels are about 30% lower for plants located near chief executive officers’ (CEOs’) hometowns. This reduction is achieved through resource-intensive control efforts, including source and waste management activities. Analyses using CEO turnover provide causal inferences. Local residents benefit from as localities...
PV252 / #394 Poster Topic: AS24 - SLE-Treatment Background/Purpose We aimed to examine glucocorticoid (GC) use over 4 decades in a population-based incident cohort of patients with SLE. Methods Residents Olmsted County, MN, SLE meeting the 2019 EULAR/ACR classification criteria between 1976-2018 were included. Index date was defined as fulfillment. GC (oral daily prednisone equivalents) abstracted from index until death or last follow-up through 12/31/2023. Cumulative dose GCs first year...
Trans-3,4,5,4′-tetramethoxystilbene (DMU-212) has shown strong antiproliferative activities against a variety of cancer cells. The aim this study was to investigate the anti-angiogenic effects DMU-212 in vitro and vivo. Human umbilical vein endothelial cells (HUVECs) were used study. Cell viability studied with MTT assay, cell apoptosis evaluated using TUNEL assay morphological observation. expression related genes proteins analyzed qRT-PCR Western blot, respectively. Angiogenesis HUVECs...
Hirudin is an anti-coagulation protein produced by the salivary glands of medicinal leech Hirudomedicinalis. It a powerful and specific thrombin inhibitor. The novel recombinant hirudin, RGD-hirudin, which contains RGD motif, competitively inhibits binding fibrinogen to GPIIb/IIIa on platelets, thus inhibiting platelet aggregation while maintaining its anticoagulant activity. Recombinant RGD-hirudin six mutant variants (Y3A, S50A, Q53A, D55A, E57A I59A), designed based molecular simulations,...
The human immunodeficiency virus-1 (HIV-1) regulatory protein Tat plays an important role during HIV-1-associated neurocognitive disorders (HAND) by inducing neuronal autophagy. In this study, we used immunohistochemistry, immunofluorescence, western blot, qRT-PCR, and RNA interference to elucidate the involvement of Bcl-2-associated athanogene 3 (BAG3) in pathogenesis HIV-1 Tat-induced autophagy HAND. We found that BAG3 expression is elevated astrocytes frontal cortex macaques infected with...
Human immunodeficiency virus (HIV) encephalitis and degeneration of cerebral cortex are established histopathologies HIV-associated neurocognitive disorders (HAND). We previously reported decreased excitatory amino acid transporter-2 (EAAT-2) astrocytic apoptosis in cortical using SIVmac239 simian-human (SHIV)-infected macaques human AIDS autopsy cases. In the present study, we added highly pathogenic SIVsm543-3-infected macaques. These animals showed similar degenerative changes frontal...
This paper examines debt maturity management through early refinancing, where firms retire their outstanding bonds before the due date and simultaneously issue new ones as replacements. Speculative-grade frequently refinance corporate to extend maturity, particularly under accommodating credit supply conditions, leading a procyclical structure. In contrast, investment-grade do not manage in same manner. I exploit protection period of callable show that extension is driven by unobservable...
The molecular mechanisms involved in human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) remain poorly understood. It has been recently reported that HIV-1 Tat transactivation requires menin, suggesting menin may be HAND pathogenesis. But the role of is not clear. Here, we found protein level was increased simian-human chimeric (SHIV)-SF162.P4 and simian (SIV) sm543-3-infected rhesus macaques compared with controls by immunohistochemistry (IHC) western blot. Menin...
This paper documents evidence that financial constraints increase firms' toxic emissions given firms actively trade off abatement costs against potential legal liabilities. Exploring three quasi-natural experiments in which resources are likely exogenously impacted, we find relaxing reduces U.S. public releases. The effects of on releases amplified when regulatory enforcement weakens and myopic managers emphasize short-term earnings performance. Overall, our highlights the real form...
Exploiting the random assignment of corporate bankruptcy filings, we estimate financial costs judicial inexperience. Despite new judges' significant prior legal experience, formal education, and rigorous hiring process, their public Chapter 11 cases spend 19% more time in realize 12 percentage point lower creditor recovery rates. Judges' learning curve is one year for small business four years complex firms. Exposure to a greater diversity businesses accelerate learning. Conservative...
Using big data on U.S. job postings, we show that firms increase skill requirements when hiring workers in states cut personal income taxes. We trace a significant driver of this effect to companies’ reallocation skilled postings across based tax differentials. The tax-induced upskilling is observed within occupations and more pronounced for high-skill positions firms. It accompanied amplified by concurrent increases information technology expenditures at local-level establishments. In...