A5008443429- Veterinary Oncology Research
- Virus-based gene therapy research
- Platelet Disorders and Treatments
- Cardiovascular Conditions and Treatments
- Veterinary Equine Medical Research
- Blood groups and transfusion
- Veterinary Medicine and Surgery
- Blood transfusion and management
- Infectious Diseases and Mycology
- Sarcoma Diagnosis and Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Microbial infections and disease research
- Blood donation and transfusion practices
- Blood properties and coagulation
- Animal health and immunology
- Hematological disorders and diagnostics
- Hedgehog Signaling Pathway Studies
- Venous Thromboembolism Diagnosis and Management
- Hemoglobinopathies and Related Disorders
- Bone health and treatments
- Cancer Research and Treatments
- Hemoglobin structure and function
- Fibroblast Growth Factor Research
- Erythrocyte Function and Pathophysiology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
The Ohio State University
2011-2020
Ohio Business College
2018
Cornell University
2011-2015
Veterinary Medical Center
2012-2015
IPO Porto
2014
Rockefeller University
2011
The Rogosin Institute
2011
Gerald P. Murphy Cancer Foundation
2011
New York Hospital Queens
2011
Columbia University
2011
Abstract Osteosarcoma is a debilitating bone cancer that affects humans, especially children and adolescents. A homologous form of osteosarcoma spontaneously occurs in dogs, its differential incidence observed across breeds allows for the investigation tumor mutations context multiple genetic backgrounds. Using whole-exome sequencing dogs from three susceptible (22 golden retrievers, 21 Rottweilers, 23 greyhounds), we found tumors show high frequency somatic copy-number alterations (SCNA),...
Hemangiosarcomas confined to the skin and underlying muscle were surgically excised in 25 dogs. Tumors staged based on their histological location (ie, dermal, hypodermal, deep). Dermal (stage I) hemangiosarcomas small, most commonly ventral-abdominal or prepucial location, associated with prolonged survival times (median survival, 780 days). hypodermal II) muscular involvement III) grouped together because of larger size, bruise-like appearance, lack anatomic predilection, biological...
Case information and histologic slides for 688 admissions of feline tissues from 12 veterinary institutions were assembled reviewed to determine obtained by biopsy or necropsy, age sex cat, tumor topography, leukemia viral antigen status, frequency mitoses, diagnosis, presence necrosis, degree sclerosis. Histologic sections examined place the lesions in one diagnostic categories National Cancer Institute working formulation (NCI WF) lymphomas lymphoid leukemia. Correlations between various...
Background : Histiocytic sarcoma is an aggressive neoplasm of dendritic cells that carries a grave prognosis. The efficacy chemotherapy against this disease unknown. purpose study was to determine the 1‐(2‐chloroethyl)‐3‐cyclohexyl‐1‐nitrosourea (CCNU) in dogs with incompletely resected or metastatic histiocytic sarcoma, describe clinical characteristics these dogs, and identify factors affecting Hypothesis Our hypothesis CCNU has activity canine can improve survival advanced disease....
The records of 20 dogs with histopathologically diagnosed gastrointestinal (GI) lymphoma (LSA) evaluated between 1970 and 1984 were reviewed. Fifteen considered to have primary GI LSA, while five had involvement in association the multicentric form. Most clinical laboratory findings nonspecific, but positive‐contrast upper radiography was suggestive LSA all evaluated. Nine extensive lymphocytic‐plasmacytic inflammatory infiltrates around neoplastic foci, resulting difficulty obtaining a...
The hemostasis profiles of 24 dogs with histologically confirmed hemangiosarcoma were prospectively evaluated. Microangiopathic hemolysis was defined as the presence schistocytes; disseminated intravascular coagulation 1) thrombocytopenia, 2) fibrin(ogen) degradation products greater than 10 micrograms/mL, 3) prolongation one or more times (activated partial thromboplastin time one-stage prothrombin time) by 25% control, 4) fragmented red blood cells (greater equal to 1+ based on a...
The clinical and pathologic features of systemic mastocytosis in 16 dogs are reported. There was no apparent breed or sex predilection, the median age at presentation 9.5 years. In 14 cases there a primary cutaneous mast cell tumor (MCT). When location compared with previous reports, association between dissemination. most common presenting signs associated were regional dissemination, edema, ulceration, abscessation. They present 12 (69%). Signs illness, including anorexia, vomiting,...
Background: Histiocytic sarcoma is an aggressive neoplasm of dendritic cells that carries a grave prognosis. The efficacy chemotherapy against this disease unknown. purpose study was to determine the 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in dogs with incompletely resected or metastatic histiocytic sarcoma, describe clinical characteristics these dogs, and identify factors affecting Hypothesis: Our hypothesis CCNU has activity canine can improve survival advanced disease....
This study evaluated the exposure of dogs to three different Ehrlichia spp. in south and central regions United States where vector-borne disease prevalence has been previously difficult ascertain, particularly beyond metropolitan areas.
Background: Bleeding disorders in patients with normal coagulation test results are frequently reported Greyhounds. The purpose of this study was to compare Greyhounds non‐Greyhounds by thromboelastography (TEG). Hypothesis: TEG parameters different from those non‐Greyhounds. Animals: Forty‐three healthy dogs (28 and 15 non‐Greyhounds) based on the physical examination, CBC, activated partial thromboplastin time, prothrombin fibrinogen, platelet count. Materials Methods: Recalcified citrated...
Abstract Osteosarcoma (OS) is the most commonly diagnosed malignant bone tumor in humans and dogs, characterized both species by extremely complex karyotypes exhibiting high frequencies of genomic imbalance. Evaluation signatures human OS using array comparative hybridization (aCGH) has assisted uncovering genetic mechanisms that result disease phenotype. Previous low‐resolution (10–20 Mb) aCGH analysis canine identified a wide range recurrent DNA copy number aberrations, indicating...
The vertebral heart size (VHS) is used to objectively assess cardiac dimensions on thoracic radiographs. A high VHS suggest the presence of pathology, such as dilated cardiomyopathy, degenerative atrioventricular valvular disease, pericardial effusion, pericardioperitoneal diaphragmatic hernia, tricuspid dysplasia, ventricular septal defect, or patent ductus arteriosus, among others. However, breed body conformation can influence VHS. Because Greyhounds have a prevalence physiologic systolic...
Background : Various chemotherapy protocols for treating lymphoma in dogs have been published; however, comparison of from different studies is difficult, especially when evaluating survival time and toxicoses. Hypothesis The choice COAP (C, cyclophosphamide; O, vincristine; A, cytosine arabinoside; P, prednisone) a modified University Wisconsin 19‐week (UW‐19) induction protocol has no influence on overall times with lymphoma. Animals One hundred one multicentric Methods Retrospective study...
There is increased pressure by governments and industry to develop national surveillance programmes evaluate antimicrobial usage (AMU) in animals.This article presents a methodological approach cost-effectiveness analysis of such programmes.Seven objectives are proposed for AMU animals: quantifying use, finding trends, detecting hotspots, identifying risk factors, encouraging research, evaluating the impact policies diseases, demonstrating compliance with regulations.Achieving these would...
Objective To evaluate the effects of epsilon aminocaproic acid ( EACA ) on prevalence postoperative bleeding in retired racing Greyhounds RRG ), and to assess its selected thrombelastography TEG fibrinolysis variables. Study Design Double‐blinded, prospective, randomized study. Methods 100 had elective ovariohysterectomy or orchiectomy were administered placebo for 3 days after surgery. variables analyzed preoperatively 24, 48, 72 hours Results Thirty percent (15/50) group delayed starting...
Circulating N-terminal PTH-related protein (PTHrP), PTH, and 1,25-dihydroxyvitamin D [1,25-(OH)2D] concentrations were measured in normal dogs with cancer-associated hypercalcemia (CAH), parathyroid adenomas, miscellaneous tumors. PTHrP was undetectable (less than 1.8 pM) increased CAH due to adenocarcinomas derived from apocrine glands of the anal sac (44.9 +/- 27 pM), lymphoma (8.3 4.4 carcinomas (13.3 11.4 pM). The concentration decreased after successful treatment CAH. had a significant...
Results from transabdominal fine‐needle aspiration of the spleen in 28 dogs and 5 cats are reported. Splenomegaly was present 79% these patients, splenic masses were 15%. Extramedullar hematopoiesis, most common cytologic diagnosis, found 24% patients associated with a variety diseases including immune hemolytic anemia, hemangiosarcoma, bone marrow hypoplasia. Hematopoietic neoplasms lymphosarcoma, plasmacytoma, myelogenous leukemia, systemic mastocytosis diagnosed patients. Other diagnoses...
Background: Greyhounds are known to have a higher systemic arterial blood pressure (BP) than non‐Greyhound dogs. Objectives: The purpose of this study was determine whether the high BP because white‐coat effect. Animals: Twenty‐two healthy retired racing (RRG) enrolled in donation program. Materials/Methods: We prospectively measured 3 environments: hospital by investigator (Hosp), home (H/I), and owner (H/O). Five serial measurements systolic, diastolic, mean pressures (SAP, DAP, MAP) as...
Background It is well established that hematocrit ( Hct ) influences whole blood thromboelastography TEG tracings. Previous studies showed hypercoagulable tracings in anemic patients despite clinical expectations anemia often prolongs bleeding. a viscoelastic assessment of clot kinetics, and the main determinant viscosity. changes may be an vitro artifact due to effect on viscosity rather than true vivo hemostasis. The independent not understood. Study Design Methods Twenty‐one samples from...
Twenty-three episodes of anticoagulant rodenticide toxicity were found in 21 dogs during a retrospective study conducted at The Ohio State University Veterinary Teaching Hospital. Dyspnea (57%), lethargy (48%), coughing/hemoptysis (30%), and pallor (26%) the most common presenting complaints. Prolonged activated clotting time (ACT), prolonged one-stage prothrombin (OSPT), partial thromboplastin (APTT) present all that had not received any prior therapy. Anemia (83%), thrombocytopenia (61%),...