A5051587922- Lipid metabolism and biosynthesis
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Reproductive Physiology in Livestock
- Zebrafish Biomedical Research Applications
- Kruppel-like factors research
- Genomics, phytochemicals, and oxidative stress
- Sirtuins and Resveratrol in Medicine
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Arctic and Antarctic ice dynamics
- Advanced Glycation End Products research
- Endoplasmic Reticulum Stress and Disease
- Genomics and Chromatin Dynamics
- Adipokines, Inflammation, and Metabolic Diseases
- Adaptive Control of Nonlinear Systems
- Milk Quality and Mastitis in Dairy Cows
- Animal Disease Management and Epidemiology
- Biopolymer Synthesis and Applications
- Liver Disease Diagnosis and Treatment
- Effects of Environmental Stressors on Livestock
- Fibroblast Growth Factor Research
- Lipid metabolism and disorders
Heilongjiang Bayi Agricultural University
2015-2025
Chenzhou First People's Hospital
2024
Yingkou Institute of Technology
2024
China Agricultural University
2024
Northeast Forestry University
2024
Southern University of Science and Technology
2021-2024
Harbin Institute of Technology
2023-2024
Ministry of Agriculture and Rural Affairs
2022-2023
Jilin University
2018-2021
North China University of Water Resources and Electric Power
2021
LYC against H<sub>2</sub>O<sub>2</sub>-induced oxidative damage in bMEC at least partly depended on activation of the NFE2L2 signaling pathway.
Dairy cows with ketosis displayed lipid metabolic disorder and high inflammatory levels. Adipose tissue is an active metabolism endocrine closely related to homeostasis inflammation. Perilipin-1 (PLIN1), adipocyte-specific lipid-coated protein, may be involved in the above physiological function. The aim of this study was investigate role PLIN1 regulation factor synthesis cow adipocytes. results showed that overexpression upregulated expression fatty acid triglyceride (TAG) molecule sterol...
Exogenous molecules derived from catabolic states (e.g., fatty acids, β-hydroxybutyrate) during periods of stress such as the periparturient period or pathogen challenges [e.g., lipopolysaccharide (LPS)] can trigger an inflammatory response in tissues liver and mammary gland. Butyrate is one major short-chain acids produced rumen, work with non-ruminants has demonstrated that it alter processes. The primary objective this study was to explore preventive effect sodium butyrate (SB) on...
Ketosis is a serious metabolic disorder characterized by systemic and hepatic oxidative stress, inflammation, apoptosis, as well reduced milk yield. Because of the paucity data on mammary responses during ketosis, aim this study was to evaluate alterations in NF-κB signaling, NLRP3 inflammasome, caspase apoptotic pathways gland dairy cows with ketosis. Blood, tissue, samples were collected from healthy [Control, blood concentration β-hydroxybutyrate (BHB) <0.6 mM, n = 10] subclinical ketosis...
Abstract Background Bovine mammary epithelial cells after calving undergo serious metabolic challenges and oxidative stress both of which could compromise autophagy. Transcription factor EB (TFEB)-mediated autophagy is an important cytoprotective mechanism against stress. However, effects TFEB-mediated on the bovine remain unknown. Therefore, main aim study was to investigate role in experiencing Results H 2 O challenge cell MAC-T increased protein abundance LC3-II, number autophagosomes...
High-yielding dairy cows in early lactation often encounter difficulties meeting the energy requirements essential for maintaining milk production. This is primarily attributed to insufficient dry matter intake, which consequently leads sustained lipolysis of adipose tissue. Fatty acids released by can disrupt metabolic homeostasis. Autophagy, an adaptive response intracellular environmental changes, considered a crucial mechanism regulating lipid metabolism and proper cellular status....
Postpartum cows experience lipolysis in adipose tissue due to negative energy balance (NEB), and accumulation of free fatty acids (FFA) leads metabolic stress tissue. Ferroptosis is a type cell death triggered by excessive buildup iron-dependent lipid peroxides, which involved the occurrence development various diseases nonruminants. However, it still unclear whether ferroptosis occurs ketotic regulatory mechanisms behind ferroptosis. Despite multiple studies demonstrating significant...
Cardamonin (CD), a naturally occurring chalcone derived from the Alpinia species, has been shown to exert antioxidant and anti-inflammatory activity, but its role in prevention of acetaminophen- (APAP-) induced hepatotoxicity remains elusive. The objective this study was determine protective effects CD against APAP-induced acute liver injury (ALI) underlying mechanisms. Wild-type or transcription factor nuclear erythroid 2-related 2- (NFE2L2-) deficient mice were treated with (50 100 mg/kg,...
Abstract Background In early lactation, bovine mammary epithelial cells undergo serious metabolic challenges and oxidative stress both of which could be alleviated by activation autophagy. Nuclear factor erythroid 2 related (NFE2L2), a master regulator cellular redox homeostasis, plays an important role in the regulation autophagy stress. Thus, objective this study was to investigate NFE2L2-mediated on response exogenous free fatty acids (FFA). Results Exogenous FFA induced linear quadratic...
Early lactation increases metabolic stress in ketotic dairy cows, leading to mitochondrial damage, apoptosis, and inflammatory response mammary epithelial cells. The pyrin domain 3 (NLRP3) pathway involving the reactive oxygen species (Mito-ROS)-induced nucleotide-binding oligomerization domain-like receptor has been recognized as a key mechanism this cell apoptosis. This study aimed elucidate underlying regulatory of Mito-ROS–NLRP3 pathway-mediated apoptosis cows with ketosis. Mitochondrial...
Abstract Chromatin accessibility plays a critical role in the regulation of cell fate decisions. Although gene expression changes have been extensively profiled at single-cell level during early embryogenesis, dynamics chromatin cis-regulatory elements remain poorly studied. Here, we used plate-based ATAC-seq method to profile over 10 000 nuclei from zebrafish embryos. We investigated several important time points immediately after zygotic genome activation (ZGA), covering key developmental...
Excessive concentrations of free fatty acids (FFA) are the main factors causing immune dysfunction and inflammation in dairy cows with ketosis. Polarization macrophages (the process freely switching from one phenotype to another) into M1 or M2 phenotypes is an important event during induced by environmental stimuli. In nonruminants, mammalian target rapamycin (mTOR)-mediated autophagy (a major waste degradation process) regulates macrophage polarization. Thus, our objective was unravel role...
Ketosis is a major metabolic disorder of high-yielding dairy cows during the transition period. Although adaptations adipose tissue are critical for successful transition, beyond lipolysis, alterations within ketosis not well known. The objective this study was to investigate proteome healthy or ketotic postpartum gain insights into biological that may contribute disease outcomes. Adipose biopsy collected on 5 and at 17 (±4) d defined according clinical symptoms serum β-hydroxybutyrate...
Aloin, a naturally occurring anthraquinone glycoside derived from the <italic>Aloe</italic> species, has antioxidant and anti-inflammatory activities, but its role in non-alcoholic steatohepatitis (NASH) remains unknown.
Adipose tissue concentration of reactive oxygen species (ROS) increases in dairy cows with ketosis, suggesting that the experiences oxidative stress. Autophagy, an adaptive response to cellular stress, has been shown promote survival and plays a critical role antioxidant responses. Dysregulation adenosine 5′-monophosphate-activated protein kinase (AMPK) is closely related responses autophagy adipocytes animal models metabolic disorders, but its bovine adipose during periods stress unknown....
Dairy cows with metabolic disorder in peripartal period display high inflammatory levels. Adipose tissue is a major endocrine organ, which closely related to systemic inflammation. Retinoic acid (RA), an active metabolite of vitamin A, has shown potential therapeutic immunomodulatory properties. The objective the study was examine effect all-trans-RA (ATRA), biologically most on lipopolysaccharide (LPS)-induced bovine adipocytes responses and elucidate underlying mechanisms. Primary cultured...
Negative energy balance (NEB) is a common pathological foundation of ketosis and fatty liver. Liver fat tissue are the major organs lipid metabolism take part in modulating oxidative capacity demands, which also key metabolic pathway that regulates NEB develop during perinatal period. Fibroblast growth factor-21 (FGF-21) recently discovered protein hormone plays an important specific regulating role adipose liver gluconeogenesis for human mouse. Our aim to investigate variation relationship...
The metabolic stress triggered by negative energy balance after calving induces mitochondrial damage of bovine mammary epithelial cells. Mitochondrial calcium uniporter regulator 1 (MCUR1) is a key protein-coding gene that mediates ion (Ca2+) uptake and plays an important role in mediating homeostasis mitochondria. aim the present study was to elucidate effects MCUR1-mediated Ca2+ on mitochondria cells response inflammatory challenge with lipopolysaccharide (LPS). Exogenous LPS resulted...