Tendon disorders comprise 30% to 50% of all activity-related injuries; chronic degenerative tendon (tendinopathy) occur frequently and are difficult treat. regeneration might be improved by injecting platelet-rich plasma (PRP), an increasingly used treatment for releasing growth factors into the tendon.To examine whether a PRP injection would improve outcome in midportion Achilles tendinopathy.A stratified, block-randomized, double-blind, placebo-controlled trial at single center (The Hague...

Objective To determine the association between cam impingement, which is hip incongruity by a non-spherical femoral head and development of osteoarthritis. Methods A nationwide prospective cohort study 1002 early symptomatic osteoarthritis patients (CHECK), standardised anteroposterior pelvic radiographs were obtained at baseline 2 5 years follow-up. Asphericity was measured α angle. Clinically, decreased internal rotation (≤20°) suggestive impingement. The strength those parameters incident...

Achilles tendon disorders, like tendinopathy, are very common among athletes. In the general population, however, knowledge about incidence of tendinopathy is lacking. Design Cross-sectional study.In a cohort 57.725 persons registered in primary care, number patients visiting practitioner (GP) with diagnosis mid-portion problems was counted using computerised registration networks GPs 2009. Subsequently, authors assessed associations these rates demographic characteristics.The rate 1.85 per...

Autologous platelet-rich plasma (PRP) application appears to improve tendon healing in traumatic injuries, but basic knowledge of how PRP promotes repair is needed.Platelet-rich has a positive effect on cell proliferation and collagen production induces the matrix-degrading enzymes endogenous growth factors by human tenocytes.Controlled laboratory study.Human tenocytes were cultured 14 days 2% fetal calf serum medium complemented with 0%, 10%, or 20% vol/vol clot releasate ([PRCR] active...

Platelet-rich plasma (PRP) has recently been postulated as a treatment for osteoarthritis (OA). Although anabolic effects of PRP on chondrocytes are well documented, no reports known addressing cartilage degeneration. Since OA is characterized by catabolic and inflammatory joint environment, the authors investigated whether was able to counteract such an environment human osteoarthritic chondrocytes.Platelet-rich inhibits interleukin-1 (IL-1) beta chondrocytes.Controlled laboratory...

Background Achilles tendinopathy is a common disease among both athletes and in the general population which use of platelet-rich plasma has recently been increasing. Good evidence for this autologous product limited, data on longer-term results are lacking. Purpose To study effects injection patients with chronic midportion at 1-year follow-up. Study Design Randomized controlled trial; Level evidence, 1. Methods Fifty-four patients, aged 18 to 70 years, 2 7 cm proximal tendon insertion were...

The Knee Injury and Osteoarthritis Outcome Score (KOOS) was constructed in Sweden. This questionnaire has proved to be valid for several orthopedic interventions of the knee. It been formally translated validated languages, but not yet Dutch. purpose present study evaluate clinimetric properties Dutch version KOOS knee patients with various stages osteoarthritis (OA). Swedish first into according a standardized procedure second tested quality. population consisted different OA (mild,...

Background: A cam deformity is a major risk factor for hip osteoarthritis, and its formation thought to be influenced by high-impact sporting activities during growth. Purpose: To (1) prospectively study whether can evolve over time in adolescents only occurs skeletal maturation (2) examine clinical or radiographic features predict the of deformity. Study Design: Cohort (prognosis); Level evidence, 2. Methods: Preprofessional soccer players (N = 63; mean age, 14.43 years; range, 12-19 years)...

Abstract Porous titanium scaffolds have good mechanical properties that make them an interesting bone substitute material for large defects. These can be produced with selective laser melting, which has the advantage of tailoring structure's architecture. Reducing strut size reduces stiffness structure and may a positive effect on formation. Two struts 120‐µm (titanium‐120) or 230‐µm (titanium‐230) were studied in load‐bearing critical femoral defect rats. The was stabilized internal plate...

Background: Cam impingement is a well-recognized cause of hip pain and might osteoarthritis the hip. Clinically, cam mostly observed in young, active male patients, but only few studies have focused on manifestation cam-type deformities during skeletal development. Purpose: To determine age onset prevalence young soccer players versus controls. Study Design: Cross-sectional study; Level evidence, 3. Methods: In this study, 89 elite preprofessional 92 controls aged 12 to 19 years were...

A prospective study was done of the results lateral release common extensor origin in sixty-three patients who had a tennis elbow. Fifty-seven these were followed for mean fifty-nine months (range, fifty to sixty-five months). At time operation, macroscopically normal all but six patients. Forty-seven (76 per cent) sixty-two evaluated at one year no pain or only slight pain, whereas before operation three (5 and sixty (95 cent), severe pain. Of fifty-seven re-examined after five years,...

Objective To assess whether a platelet-rich plasma (PRP) injection leads to an enhanced tendon structure and neovascularisation, measured with ultrasonographic techniques, in chronic midportion Achilles tendinopathy. Design Double-blind, randomised, placebo-controlled clinical trial. Setting Sports medical department of The Hague centre. Patients 54 patients tendinopathy were included. Interventions randomised eccentric exercise therapy either PRP (PRP group) or saline (placebo group). Main...

A prospective, randomised, controlled trial compared two different techniques of high tibial osteotomy with a lateral closing wedge or medial opening wedge, stabilised by Puddu plate. The clinical outcome and radiological results were examined at one year. primary measure was the achievement an overcorrection valgus 4 degrees . Secondary measures severity pain (visual analogue scale), knee function (Hospital for Special Surgery score), walking distance. Between January 2001 April 2004, 92...

Bone grafts are required to repair large bone defects after tumour resection or trauma. The availability of patients' own tissue that can be used for these procedures is limited. Thus far engineering has not lead an implant which could as alternative in replacement surgery. This mainly due problems vascularisation the implanted tissues leading core necrosis and failure. Recently it was discovered embryonic stem cells form via endochondral pathway, thereby turning in-vitro created cartilage...

Our aim was to compare the degree of patellar descent and alteration in angle inclination tibial plateau lateral closing-wedge medial opening-wedge high osteotomy (HTO) 51 consecutive patients with osteoarthritis compartment varus malalignment. Patellar height measured by Insall-Salvati (IS) Blackburne-Peel (BP) ratios. The determined Moore-Harvey (MH) method. Multivariate linear regression analysis used determine influence type HTO (closing vs opening wedge) on post-operative or...