A5009266334- Axon Guidance and Neuronal Signaling
- Environmental Toxicology and Ecotoxicology
- Marine Biology and Environmental Chemistry
- Analytical chemistry methods development
- Toxic Organic Pollutants Impact
- Apelin-related biomedical research
- Alzheimer's disease research and treatments
- Heavy metals in environment
- Neurogenesis and neuroplasticity mechanisms
- Metabolomics and Mass Spectrometry Studies
- Tryptophan and brain disorders
- Microplastics and Plastic Pollution
- HIV/AIDS drug development and treatment
- Analytical Methods in Pharmaceuticals
- Neuroinflammation and Neurodegeneration Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Water Quality and Pollution Assessment
- Cervical Cancer and HPV Research
- Management, Economics, and Public Policy
- Biochemical and Molecular Research
- Nerve injury and regeneration
- Geochemistry and Elemental Analysis
- Dementia and Cognitive Impairment Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Pneumocystis jirovecii pneumonia detection and treatment
University of Naples Federico II
2021-2025
University of Molise
2025
Cardiff University
2017
Sapienza University of Rome
2013
University of Genoa
2010
The role of tumor necrosis factor-α (TNF-α) in Alzheimer’s disease (AD) has recently become a topic debate. TNF-α levels increase the blood patients with AD, and amyloid beta (Aβ) plaques contain deposits. therapeutic efficacy blocking AD remains controversial as it is mostly based on preclinical studies. Thus, whether how contributes to amyloidogenic processes still an open question be addressed. We analyzed plasma Aβ42 subjective cognitive impairment (SCI), mild (MCI), healthy volunteers...
Polycyclic aromatic hydrocarbons (PAHs) consist of a group over 100 different organic compounds mainly generated by anthropogenic activities. Because their low water solubility, they tend to be accumulated in sediment, where degradation rate is very low. Few studies have been carried out so far investigate the effects PAHs on Artemia franciscana. easy manage at laboratory scale, but it not sensitive biological model considering traditional endpoints (i.e., mortality). In addition evaluating...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that leads to cognitive and functional decline primarily affects the elderly population. Metabolic alterations, particularly in amino acid fatty pathways, are increasingly being recognized AD. However, role of sex these metabolic changes remains insufficiently understood, despite evidence suggesting AD may manifest more strongly females. This study investigated sex-specific patterns by analyzing routine non-routine...
Recently, measurable peripheral biomarkers in the plasma of patients with Alzheimer's disease (AD) have gained considerable clinical interest. Several studies identified one or more blood signatures that may facilitate development novel diagnostic and therapeutic strategies. For instance, changes amyloid β42 (Aβ42) levels been largely investigated AD correlated progression pathology, although controversial results. In addition, tumor necrosis factor α (TNFα) has as an inflammatory biomarker...
Polycyclic aromatic hydrocarbons (PAHs) are widespread across the globe and can be highly toxic for marine environment. This research investigated short-term (48 h of exposure) effects PAHs mixtures on nauplii adult crustacean Artemia franciscana considering impact in term toxicity changes gene expression. Results showed that all combinations caused additive or synergic with exception naphthalene + phenanthrene (NAP PHE; Combination Index (CI) = 22.3), while benzo(k)fluoranthene BkF; CI 7.8)...
Semaphorins (Sema) belong to a large family of repellent guidance cues instrumental in guiding axons during development. In particular, Class 3 Sema (Sema 3) is among the best characterized members and only produced as secreted proteins mammals, thereby exerting both autocrine paracrine functions. Intriguingly, an increasing number studies supports crucial role 3A hippocampal cortical neurodevelopment. This means that alterations signaling might compromise circuits predispose disorders such...
Semaphorin 3A (SEMA3A) plays a crucial role in the development, differentiation, and plasticity of specific types neurons that secrete Gonadotropin-Releasing Hormone (GnRH) regulates acquisition maintenance reproductive competence humans mice. Its insufficient expression has been linked to disorders humans, which are characterized by reduced or failed sexual competence. Various mutations, polymorphisms, alternatively spliced variants SEMA3A have associated with infertility. One common causes...
The discovery of various sartans, which are among the most used antihypertensive drugs in world, is increasingly frequent not only wastewater but also surface water and, some cases, even drinking or groundwater. In this paper, degradation pathway olmesartan acid, one was investigated by simulating chlorination process normally a treatment plant to reduce similar emerging pollutants. structures nine isolated byproducts (DPs), eight were for first time, separated via chromatography column and...
For many years, there has been a debate on the polluting loads affecting Gulf of Naples, one Italy's most spectacular and iconic landscape. The wide territory bordering includes Sarno river basin (SRB) managed by Southern Apennines River Basin District Authority in framework Unit Management (UoM-Sarno). paper investigated anthropogenic pressures their spatial distribution UoM-Sarno, revealing as SRB represents hotspot pollution mainly due to high population density widespread hydro-demanding...
Background The risk of progression to cancer from HPV infection is increased in HIV-positive subjects. Anal a concern among men who have sex with (MSM), especially the setting HIV infection. Methods: Cross-sectional study including 62 injection drug users (IDUs) without history receptive anal intercourse and 110 MSM. All patients were receiving HAART HIV-RNA <37 copies/mL. Patients answered self-administered questionnaire investigating their sexual habits. Participants underwent brushing...
Art history is one of the humanities subjects ideally suited to innovative teaching methods that leverage new technologies. It can be taught through communicative practices based on multimedia, becoming an ideal arena for technology enhance and stimulate learning. This article presents some considerations about currently available art e-books, a digital set become standard format textbooks at school. Together with interactive whiteboards), e-books are spearheading introduction technologies...
Abstract Background Semaphorins (Sema) belong to a large family of repellent guidance cues instrumental in guiding axons during development. In particular, Class 3 Sema (Sema 3) are among the best characterized members and only produced as secreted proteins mammals, thereby exerting both autocrine paracrine functions. Intriguingly, an increasing number studies supports crucial role 3A hippocampal cortical neurodevelopment, meaning that alterations signaling might compromise circuits...
Polycyclic aromatic hydrocarbons (PAHs) consist of a group over 100 different organic compounds mainly generated and released by anthropogenic activities. They are formed two or more fused benzene rings. Because their low water solubility hydrophobicity, they tend to be adsorbed accumulated in sediment, where degradation rate is very low. To the best our knowledge, no studies have been carried out so far investigate vitro effects PAHs on Artemia franciscana. easy manage at lab scale, but it...